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Q0IJ08

- DYR1A_XENTR

UniProt

Q0IJ08 - DYR1A_XENTR

Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

dyrk1a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei180 – 1801ATPPROSITE-ProRule annotation
    Active sitei279 – 2791Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi157 – 1659ATPPROSITE-ProRule annotation
    Nucleotide bindingi230 – 2334ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
    3. protein serine/threonine kinase activity Source: UniProtKB
    4. protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine phosphorylation Source: UniProtKB
    2. protein autophosphorylation Source: UniProtKB
    3. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.1)
    Alternative name(s):
    Protein kinase minibrain homolog
    Gene namesi
    Name:dyrk1aBy similarity
    Synonyms:mnbImported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1017105. dyrk1a.

    Subcellular locationi

    Nucleus speckle By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 751751Dual specificity tyrosine-phosphorylation-regulated kinase 1APRO_0000284708Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on tyrosine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000058302.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IJ08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini151 – 471321Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi109 – 12618Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi482 – 51635Ser-richSequence AnalysisAdd
    BLAST
    Compositional biasi590 – 61021His-richSequence AnalysisAdd
    BLAST
    Compositional biasi597 – 60711Poly-HisSequence AnalysisAdd
    BLAST
    Compositional biasi623 – 65937Ser-richSequence AnalysisAdd
    BLAST

    Domaini

    The polyhistidine repeats act as targeting signals to nuclear speckles.By similarity

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG051425.
    KOiK08825.

    Family and domain databases

    InterProiIPR028318. DYRK1A.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0IJ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN    50
    DQQASALPYN DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN 100
    EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR 150
    YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE 200
    LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS 250
    LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 300
    GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE 350
    PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT 400
    KDGKKEYKPP GTRKLHNLLG VETGGPGGRR GGESGHTVAD YLKFKDLILR 450
    MLDYDAKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT 500
    SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV 550
    RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH 600
    HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST 650
    TSSSTSSSST GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET 700
    GITGHPDYQY SANTGPGHYV TEGHLTMRQG MDREDSPMTG VCVQQSPVAS 750
    S 751
    Length:751
    Mass (Da):84,292
    Last modified:October 3, 2006 - v1
    Checksum:iB206294560456D66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121291 mRNA. Translation: AAI21292.1.
    RefSeqiNP_001072280.1. NM_001078812.1.
    UniGeneiStr.49084.

    Genome annotation databases

    GeneIDi779733.
    KEGGixtr:779733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121291 mRNA. Translation: AAI21292.1 .
    RefSeqi NP_001072280.1. NM_001078812.1.
    UniGenei Str.49084.

    3D structure databases

    ProteinModelPortali Q0IJ08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000058302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 779733.
    KEGGi xtr:779733.

    Organism-specific databases

    CTDi 1859.
    Xenbasei XB-GENE-1017105. dyrk1a.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG051425.
    KOi K08825.

    Family and domain databases

    InterProi IPR028318. DYRK1A.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24058:SF28. PTHR24058:SF28. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiDYR1A_XENTR
    AccessioniPrimary (citable) accession number: Q0IJ08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3