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Q0IJ08 (DYR1A_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

EC=2.7.12.1
Alternative name(s):
Protein kinase minibrain homolog
Gene names
Name:dyrk1a
Synonyms:mnb
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates By similarity. UniProtKB Q13627

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus speckle By similarity.

Domain

The polyhistidine repeats act as targeting signals to nuclear speckles By similarity.

Post-translational modification

Autophosphorylated on tyrosine residues By similarity. UniProtKB Q13627

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 751751Dual specificity tyrosine-phosphorylation-regulated kinase 1A
PRO_0000284708

Regions

Domain151 – 471321Protein kinase
Nucleotide binding157 – 1659ATP By similarity
Nucleotide binding230 – 2334ATP By similarity
Motif109 – 12618Bipartite nuclear localization signal Potential
Compositional bias482 – 51635Ser-rich
Compositional bias590 – 61021His-rich
Compositional bias597 – 60711Poly-His
Compositional bias623 – 65937Ser-rich

Sites

Active site2791Proton acceptor By similarity
Binding site1801ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IJ08 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: B206294560456D66

FASTA75184,292
        10         20         30         40         50         60 
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN DQQASALPYN 

        70         80         90        100        110        120 
DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS 

       130        140        150        160        170        180 
HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK 

       190        200        210        220        230        240 
IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL 

       250        260        270        280        290        300 
LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 

       310        320        330        340        350        360 
GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD 

       370        380        390        400        410        420 
QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT KDGKKEYKPP GTRKLHNLLG 

       430        440        450        460        470        480 
VETGGPGGRR GGESGHTVAD YLKFKDLILR MLDYDAKTRI QPYYALQHSF FKKTADEGTN 

       490        500        510        520        530        540 
TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA 

       550        560        570        580        590        600 
MDCETHSPQV RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH 

       610        620        630        640        650        660 
HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST TSSSTSSSST 

       670        680        690        700        710        720 
GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET GITGHPDYQY SANTGPGHYV 

       730        740        750 
TEGHLTMRQG MDREDSPMTG VCVQQSPVAS S 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC121291 mRNA. Translation: AAI21292.1.
RefSeqNP_001072280.1. NM_001078812.1.
UniGeneStr.49084.

3D structure databases

ProteinModelPortalQ0IJ08.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000058302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779733.
KEGGxtr:779733.

Organism-specific databases

CTD1859.
XenbaseXB-GENE-1017105. dyrk1a.

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG051425.
KOK08825.

Family and domain databases

InterProIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR1A_XENTR
AccessionPrimary (citable) accession number: Q0IJ08
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families