Q0IJ08 (DYR1A_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
EC=2.7.12.1

Alternative name(s):
Protein kinase minibrain homolog

Gene names

Name:	dyrk1a
Synonyms:	mnb

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	751 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates By similarity. UniProtKB Q13627
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Nucleus speckle By similarity.
Domain	The polyhistidine repeats act as targeting signals to nuclear speckles By similarity.
Post-translational modification	Autophosphorylated on tyrosine residues By similarity. UniProtKB Q13627
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB protein autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nuclear speck Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 751	751	Dual specificity tyrosine-phosphorylation-regulated kinase 1A		PRO_0000284708
Regions
	Domain	151 – 471	321	Protein kinase
	Nucleotide binding	157 – 165	9	ATP By similarity
	Motif	109 – 126	18	Bipartite nuclear localization signal Potential
	Compositional bias	482 – 516	35	Ser-rich
	Compositional bias	590 – 610	21	His-rich
	Compositional bias	597 – 607	11	Poly-His
	Compositional bias	623 – 659	37	Ser-rich
Sites
	Active site	279	1	Proton acceptor By similarity
	Binding site	180	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0IJ08 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: B206294560456D66	FASTA	751	84,292
	10 20 30 40 50 60 MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN DQQASALPYN 70 80 90 100 110 120 DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS 130 140 150 160 170 180 HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK 190 200 210 220 230 240 IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL 250 260 270 280 290 300 LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 310 320 330 340 350 360 GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD 370 380 390 400 410 420 QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT KDGKKEYKPP GTRKLHNLLG 430 440 450 460 470 480 VETGGPGGRR GGESGHTVAD YLKFKDLILR MLDYDAKTRI QPYYALQHSF FKKTADEGTN 490 500 510 520 530 540 TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA 550 560 570 580 590 600 MDCETHSPQV RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH 610 620 630 640 650 660 HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST TSSSTSSSST 670 680 690 700 710 720 GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET GITGHPDYQY SANTGPGHYV 730 740 750 TEGHLTMRQG MDREDSPMTG VCVQQSPVAS S

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC121291 mRNA. Translation: AAI21292.1.
RefSeq	NP_001072280.1. NM_001078812.1.
UniGene	Str.49084.
3D structure databases
ProteinModelPortal	Q0IJ08.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000058302.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	779733.
KEGG	xtr:779733.
Organism-specific databases
CTD	1859.
Xenbase	XB-GENE-1017105. dyrk1a.
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG051425.
KO	K08825.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYR1A_XENTR

Accession

Primary (citable) accession number: Q0IJ08

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	October 3, 2006
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program