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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

dyrk1a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei180 – 1801ATPPROSITE-ProRule annotation
Active sitei279 – 2791Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1659ATPPROSITE-ProRule annotation
Nucleotide bindingi230 – 2334ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.1)
Alternative name(s):
Protein kinase minibrain homolog
Gene namesi
Name:dyrk1aBy similarity
Synonyms:mnbImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1017105. dyrk1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Dual specificity tyrosine-phosphorylation-regulated kinase 1APRO_0000284708Add
BLAST

Post-translational modificationi

Autophosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0IJ08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 471321Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 12618Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi482 – 51635Ser-richSequence AnalysisAdd
BLAST
Compositional biasi590 – 61021His-richSequence AnalysisAdd
BLAST
Compositional biasi597 – 60711Poly-HisSequence AnalysisAdd
BLAST
Compositional biasi623 – 65937Ser-richSequence AnalysisAdd
BLAST

Domaini

The polyhistidine repeats act as targeting signals to nuclear speckles.By similarity

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG051425.
InParanoidiQ0IJ08.
KOiK08825.

Family and domain databases

InterProiIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IJ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN
60 70 80 90 100
DQQASALPYN DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN
110 120 130 140 150
EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR
160 170 180 190 200
YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE
210 220 230 240 250
LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS
260 270 280 290 300
LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF
310 320 330 340 350
GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE
360 370 380 390 400
PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT
410 420 430 440 450
KDGKKEYKPP GTRKLHNLLG VETGGPGGRR GGESGHTVAD YLKFKDLILR
460 470 480 490 500
MLDYDAKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT
510 520 530 540 550
SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV
560 570 580 590 600
RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH
610 620 630 640 650
HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST
660 670 680 690 700
TSSSTSSSST GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET
710 720 730 740 750
GITGHPDYQY SANTGPGHYV TEGHLTMRQG MDREDSPMTG VCVQQSPVAS

S
Length:751
Mass (Da):84,292
Last modified:October 3, 2006 - v1
Checksum:iB206294560456D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121291 mRNA. Translation: AAI21292.1.
RefSeqiNP_001072280.1. NM_001078812.1.
UniGeneiStr.49084.

Genome annotation databases

GeneIDi779733.
KEGGixtr:779733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121291 mRNA. Translation: AAI21292.1.
RefSeqiNP_001072280.1. NM_001078812.1.
UniGeneiStr.49084.

3D structure databases

ProteinModelPortaliQ0IJ08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi779733.
KEGGixtr:779733.

Organism-specific databases

CTDi1859.
XenbaseiXB-GENE-1017105. dyrk1a.

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG051425.
InParanoidiQ0IJ08.
KOiK08825.

Family and domain databases

InterProiIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiDYR1A_XENTR
AccessioniPrimary (citable) accession number: Q0IJ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 3, 2006
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.