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Q0IJ08

- DYR1A_XENTR

UniProt

Q0IJ08 - DYR1A_XENTR

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Protein
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene
dyrk1a, mnb
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei180 – 1801ATP By similarity
Active sitei279 – 2791Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1659ATP By similarity
Nucleotide bindingi230 – 2334ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB
  3. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  4. protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine phosphorylation Source: UniProtKB
  2. protein autophosphorylation Source: UniProtKB
  3. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.1)
Alternative name(s):
Protein kinase minibrain homolog
Gene namesi
Name:dyrk1a
Synonyms:mnb
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1017105. dyrk1a.

Subcellular locationi

Nucleus speckle By similarity

GO - Cellular componenti

  1. nuclear speck Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Dual specificity tyrosine-phosphorylation-regulated kinase 1A
PRO_0000284708Add
BLAST

Post-translational modificationi

Autophosphorylated on tyrosine residues By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058302.

Structurei

3D structure databases

ProteinModelPortaliQ0IJ08.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 471321Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 12618Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi482 – 51635Ser-rich
Add
BLAST
Compositional biasi590 – 61021His-rich
Add
BLAST
Compositional biasi597 – 60711Poly-His
Add
BLAST
Compositional biasi623 – 65937Ser-rich
Add
BLAST

Domaini

The polyhistidine repeats act as targeting signals to nuclear speckles By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG051425.
KOiK08825.

Family and domain databases

InterProiIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IJ08-1 [UniParc]FASTAAdd to Basket

« Hide

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN    50
DQQASALPYN DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN 100
EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR 150
YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE 200
LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS 250
LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 300
GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE 350
PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT 400
KDGKKEYKPP GTRKLHNLLG VETGGPGGRR GGESGHTVAD YLKFKDLILR 450
MLDYDAKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT 500
SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV 550
RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH 600
HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST 650
TSSSTSSSST GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET 700
GITGHPDYQY SANTGPGHYV TEGHLTMRQG MDREDSPMTG VCVQQSPVAS 750
S 751
Length:751
Mass (Da):84,292
Last modified:October 3, 2006 - v1
Checksum:iB206294560456D66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121291 mRNA. Translation: AAI21292.1.
RefSeqiNP_001072280.1. NM_001078812.1.
UniGeneiStr.49084.

Genome annotation databases

GeneIDi779733.
KEGGixtr:779733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121291 mRNA. Translation: AAI21292.1 .
RefSeqi NP_001072280.1. NM_001078812.1.
UniGenei Str.49084.

3D structure databases

ProteinModelPortali Q0IJ08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000058302.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779733.
KEGGi xtr:779733.

Organism-specific databases

CTDi 1859.
Xenbasei XB-GENE-1017105. dyrk1a.

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG051425.
KOi K08825.

Family and domain databases

InterProi IPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24058:SF28. PTHR24058:SF28. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDYR1A_XENTR
AccessioniPrimary (citable) accession number: Q0IJ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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