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Q0IIW3

- SODC_XENTR

UniProt

Q0IIW3 - SODC_XENTR

Protein

Superoxide dismutase [Cu-Zn]

Gene

sod1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.By similarity

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451Copper; catalyticBy similarity
    Metal bindingi47 – 471Copper; catalyticBy similarity
    Metal bindingi62 – 621Copper; catalyticBy similarity
    Metal bindingi62 – 621Zinc; structuralBy similarity
    Metal bindingi70 – 701Zinc; structuralBy similarity
    Metal bindingi79 – 791Zinc; structuralBy similarity
    Metal bindingi82 – 821Zinc; structuralBy similarity
    Metal bindingi118 – 1181Copper; catalyticBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. neuron cellular homeostasis Source: Ensembl
    2. response to metal ion Source: Ensembl
    3. response to methylmercury Source: Ensembl
    4. response to xenobiotic stimulus Source: Ensembl

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_195451. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn]By similarity (EC:1.15.1.1)
    Gene namesi
    Name:sod1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1006488. sod1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 151150Superoxide dismutase [Cu-Zn]By similarityPRO_0000392433Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi6 – 61S-palmitoyl cysteineBy similarity
    Disulfide bondi56 ↔ 144By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ0IIW3.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000015994.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IIW3.
    SMRiQ0IIW3. Positions 2-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263447.
    HOVERGENiHBG000062.
    KOiK04565.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0IIW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRAVCVLAG SGDVKGVVHF QQQDEGPVTV EGKIYGLTDG KHGFHIHEFG    50
    DNTNGCISAG PHFNPESKTH GAPEDAVRHV GDLGNVTAKD GVAEFKLTDS 100
    LISLKGNHSI IGRCAVVHEK EDDLGKGGND ESLKTGNAGG RLACGVIGLC 150
    Q 151
    Length:151
    Mass (Da):15,698
    Last modified:October 3, 2006 - v1
    Checksum:i6E4E5F8260D4CD4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121540 mRNA. Translation: AAI21541.1.
    RefSeqiNP_001016252.1. NM_001016252.2.
    UniGeneiStr.1999.

    Genome annotation databases

    GeneIDi549006.
    KEGGixtr:549006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC121540 mRNA. Translation: AAI21541.1 .
    RefSeqi NP_001016252.1. NM_001016252.2.
    UniGenei Str.1999.

    3D structure databases

    ProteinModelPortali Q0IIW3.
    SMRi Q0IIW3. Positions 2-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000015994.

    Proteomic databases

    PaxDbi Q0IIW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 549006.
    KEGGi xtr:549006.

    Organism-specific databases

    CTDi 6647.
    Xenbasei XB-GENE-1006488. sod1.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263447.
    HOVERGENi HBG000062.
    KOi K04565.

    Enzyme and pathway databases

    Reactomei REACT_195451. Detoxification of Reactive Oxygen Species.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: N6Imported.
      Tissue: OviductImported.

    Entry informationi

    Entry nameiSODC_XENTR
    AccessioniPrimary (citable) accession number: Q0IIW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3