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Protein

Superoxide dismutase [Cu-Zn]

Gene

sod1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Copper; catalyticBy similarity1
Metal bindingi47Copper; catalyticBy similarity1
Metal bindingi62Copper; catalyticBy similarity1
Metal bindingi62Zinc; structuralBy similarity1
Metal bindingi70Zinc; structuralBy similarity1
Metal bindingi79Zinc; structuralBy similarity1
Metal bindingi82Zinc; structuralBy similarity1
Metal bindingi118Copper; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]By similarity (EC:1.15.1.1)
Gene namesi
Name:sod1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1006488. sod1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003924332 – 151Superoxide dismutase [Cu-Zn]By similarityAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi6S-palmitoyl cysteineBy similarity1
Disulfide bondi56 ↔ 144By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ0IIW3.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015994.

Structurei

3D structure databases

ProteinModelPortaliQ0IIW3.
SMRiQ0IIW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiQ0IIW3.
KOiK04565.
OrthoDBiEOG091G0OG2.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR036423. SOD-like_Cu/Zn_dom_sf.
IPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0IIW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAVCVLAG SGDVKGVVHF QQQDEGPVTV EGKIYGLTDG KHGFHIHEFG
60 70 80 90 100
DNTNGCISAG PHFNPESKTH GAPEDAVRHV GDLGNVTAKD GVAEFKLTDS
110 120 130 140 150
LISLKGNHSI IGRCAVVHEK EDDLGKGGND ESLKTGNAGG RLACGVIGLC

Q
Length:151
Mass (Da):15,698
Last modified:October 3, 2006 - v1
Checksum:i6E4E5F8260D4CD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121540 mRNA. Translation: AAI21541.1.
RefSeqiNP_001016252.1. NM_001016252.2.
UniGeneiStr.1999.

Genome annotation databases

GeneIDi549006.
KEGGixtr:549006.

Similar proteinsi

Entry informationi

Entry nameiSODC_XENTR
AccessioniPrimary (citable) accession number: Q0IIW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families