Q0IIW3 (SODC_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

sod1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity. UniProtKB P15107
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2. UniProtKB P15107
Cofactor	Binds 1 copper ion per subunit By similarity. UniProtKB P15107 Binds 1 zinc ion per subunit By similarity. UniProtKB P15107
Subunit structure	Homodimer By similarity. UniProtKB P00441
Subcellular location	Cytoplasm By similarity UniProtKB P15107.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuron homeostasis Inferred from electronic annotation. Source: Compara response to metal ion Inferred from electronic annotation. Source: Compara response to methylmercury Inferred from electronic annotation. Source: Compara response to xenobiotic stimulus Inferred from electronic annotation. Source: Compara superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P15107
	Chain	2 – 151	150	Superoxide dismutase [Cu-Zn] UniProtKB P15107		PRO_0000392433
Sites
	Metal binding	45	1	Copper; catalytic By similarity UniProtKB P15107
	Metal binding	47	1	Copper; catalytic By similarity UniProtKB P15107
	Metal binding	62	1	Copper; catalytic By similarity UniProtKB P15107
	Metal binding	62	1	Zinc; structural By similarity UniProtKB P15107
	Metal binding	70	1	Zinc; structural By similarity UniProtKB P15107
	Metal binding	79	1	Zinc; structural By similarity UniProtKB P15107
	Metal binding	82	1	Zinc; structural By similarity UniProtKB P15107
	Metal binding	118	1	Copper; catalytic By similarity UniProtKB P15107
Amino acid modifications
	Disulfide bond	56 ↔ 144		By similarity UniProtKB P15107

Sequences

	Sequence		Length	Mass (Da)
	Q0IIW3 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 6E4E5F8260D4CD4B	FASTA	151	15,698
	10 20 30 40 50 60 MVRAVCVLAG SGDVKGVVHF QQQDEGPVTV EGKIYGLTDG KHGFHIHEFG DNTNGCISAG 70 80 90 100 110 120 PHFNPESKTH GAPEDAVRHV GDLGNVTAKD GVAEFKLTDS LISLKGNHSI IGRCAVVHEK 130 140 150 EDDLGKGGND ESLKTGNAGG RLACGVIGLC Q

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: N6. Tissue: Oviduct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC121540 mRNA. Translation: AAI21541.1.
RefSeq	NP_001016252.1. NM_001016252.2.
UniGene	Str.1999.
3D structure databases
ProteinModelPortal	Q0IIW3.
SMR	Q0IIW3. Positions 2-148.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000015994.
Proteomic databases
PaxDb	Q0IIW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	549006.
KEGG	xtr:549006.
Organism-specific databases
CTD	6647.
Xenbase	XB-GENE-1006488. sod1.
Phylogenomic databases
eggNOG	COG2032.
HOGENOM	HOG000263447.
HOVERGEN	HBG000062.
KO	K04565.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_XENTR

Accession

Primary (citable) accession number: Q0IIW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 23, 2010
Last sequence update:	October 3, 2006
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program