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Q0IIW3

- SODC_XENTR

UniProt

Q0IIW3 - SODC_XENTR

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Protein
Superoxide dismutase [Cu-Zn]
Gene
sod1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.By similarity

Cofactori

Binds 1 copper ion per subunit By similarity.By similarity
Binds 1 zinc ion per subunit By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Copper; catalytic By similarityBy similarity
Metal bindingi47 – 471Copper; catalytic By similarityBy similarity
Metal bindingi62 – 621Copper; catalytic By similarityBy similarity
Metal bindingi62 – 621Zinc; structural By similarityBy similarity
Metal bindingi70 – 701Zinc; structural By similarityBy similarity
Metal bindingi79 – 791Zinc; structural By similarityBy similarity
Metal bindingi82 – 821Zinc; structural By similarityBy similarity
Metal bindingi118 – 1181Copper; catalytic By similarityBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC

GO - Biological processi

  1. neuron cellular homeostasis Source: Ensembl
  2. response to metal ion Source: Ensembl
  3. response to methylmercury Source: Ensembl
  4. response to xenobiotic stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_195451. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sod1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1006488. sod1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarityBy similarity
Chaini2 – 151150Superoxide dismutase [Cu-Zn]By similarity
PRO_0000392433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi6 – 61S-palmitoyl cysteine By similarity
Disulfide bondi56 ↔ 144 By similarityBy similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ0IIW3.

Interactioni

Subunit structurei

Homodimer By similarity.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015994.

Structurei

3D structure databases

ProteinModelPortaliQ0IIW3.
SMRiQ0IIW3. Positions 2-148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0IIW3-1 [UniParc]FASTAAdd to Basket

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MVRAVCVLAG SGDVKGVVHF QQQDEGPVTV EGKIYGLTDG KHGFHIHEFG    50
DNTNGCISAG PHFNPESKTH GAPEDAVRHV GDLGNVTAKD GVAEFKLTDS 100
LISLKGNHSI IGRCAVVHEK EDDLGKGGND ESLKTGNAGG RLACGVIGLC 150
Q 151
Length:151
Mass (Da):15,698
Last modified:October 3, 2006 - v1
Checksum:i6E4E5F8260D4CD4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121540 mRNA. Translation: AAI21541.1.
RefSeqiNP_001016252.1. NM_001016252.2.
UniGeneiStr.1999.

Genome annotation databases

GeneIDi549006.
KEGGixtr:549006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121540 mRNA. Translation: AAI21541.1 .
RefSeqi NP_001016252.1. NM_001016252.2.
UniGenei Str.1999.

3D structure databases

ProteinModelPortali Q0IIW3.
SMRi Q0IIW3. Positions 2-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000015994.

Proteomic databases

PaxDbi Q0IIW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 549006.
KEGGi xtr:549006.

Organism-specific databases

CTDi 6647.
Xenbasei XB-GENE-1006488. sod1.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263447.
HOVERGENi HBG000062.
KOi K04565.

Enzyme and pathway databases

Reactomei REACT_195451. Detoxification of Reactive Oxygen Species.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6.
    Tissue: Oviduct.

Entry informationi

Entry nameiSODC_XENTR
AccessioniPrimary (citable) accession number: Q0IIW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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