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Q0IIW3

- SODC_XENTR

UniProt

Q0IIW3 - SODC_XENTR

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Protein

Superoxide dismutase [Cu-Zn]

Gene

sod1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.By similarity

Cofactori

Binds 1 copper ion per subunit.By similarity
Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Copper; catalyticBy similarity
Metal bindingi47 – 471Copper; catalyticBy similarity
Metal bindingi62 – 621Copper; catalyticBy similarity
Metal bindingi62 – 621Zinc; structuralBy similarity
Metal bindingi70 – 701Zinc; structuralBy similarity
Metal bindingi79 – 791Zinc; structuralBy similarity
Metal bindingi82 – 821Zinc; structuralBy similarity
Metal bindingi118 – 1181Copper; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC

GO - Biological processi

  1. neuron cellular homeostasis Source: Ensembl
  2. response to metal ion Source: Ensembl
  3. response to methylmercury Source: Ensembl
  4. response to xenobiotic stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_195451. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]By similarity (EC:1.15.1.1)
Gene namesi
Name:sod1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1006488. sod1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 151150Superoxide dismutase [Cu-Zn]By similarityPRO_0000392433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi6 – 61S-palmitoyl cysteineBy similarity
Disulfide bondi56 ↔ 144By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ0IIW3.

Expressioni

Gene expression databases

ExpressionAtlasiQ0IIW3. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015994.

Structurei

3D structure databases

ProteinModelPortaliQ0IIW3.
SMRiQ0IIW3. Positions 2-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiQ0IIW3.
KOiK04565.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0IIW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRAVCVLAG SGDVKGVVHF QQQDEGPVTV EGKIYGLTDG KHGFHIHEFG
60 70 80 90 100
DNTNGCISAG PHFNPESKTH GAPEDAVRHV GDLGNVTAKD GVAEFKLTDS
110 120 130 140 150
LISLKGNHSI IGRCAVVHEK EDDLGKGGND ESLKTGNAGG RLACGVIGLC

Q
Length:151
Mass (Da):15,698
Last modified:October 3, 2006 - v1
Checksum:i6E4E5F8260D4CD4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121540 mRNA. Translation: AAI21541.1.
RefSeqiNP_001016252.1. NM_001016252.2.
UniGeneiStr.1999.

Genome annotation databases

GeneIDi549006.
KEGGixtr:549006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC121540 mRNA. Translation: AAI21541.1 .
RefSeqi NP_001016252.1. NM_001016252.2.
UniGenei Str.1999.

3D structure databases

ProteinModelPortali Q0IIW3.
SMRi Q0IIW3. Positions 2-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000015994.

Proteomic databases

PaxDbi Q0IIW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 549006.
KEGGi xtr:549006.

Organism-specific databases

CTDi 6647.
Xenbasei XB-GENE-1006488. sod1.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263447.
HOVERGENi HBG000062.
InParanoidi Q0IIW3.
KOi K04565.

Enzyme and pathway databases

Reactomei REACT_195451. Detoxification of Reactive Oxygen Species.

Gene expression databases

ExpressionAtlasi Q0IIW3. baseline.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6Imported.
    Tissue: OviductImported.

Entry informationi

Entry nameiSODC_XENTR
AccessioniPrimary (citable) accession number: Q0IIW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3