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Protein
Submitted name:

Purinergic receptor P2Y, G-protein coupled, 12

Gene

P2RY12

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-BTA-392170. ADP signalling through P2Y purinoceptor 12.
R-BTA-417957. P2Y receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Purinergic receptor P2Y, G-protein coupled, 12Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:P2RY12Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4425HelicalSequence analysisAdd
BLAST
Transmembranei56 – 7924HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11719HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei186 – 21025HelicalSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Transmembranei281 – 29919HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSBTAG00000015837.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 295257G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
KOiK04298.
OMAiIKVFIII.
OrthoDBiEOG091G0B3H.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLTSVAGN SSQCSRDYKI TQVLFPLLYT VLFFVGLITN SLAMRIFFQI
60 70 80 90 100
RSKSNFIIFL KNTVISDLLM ILTFPFKILS DTKLGTGPLR AFVCQVTSVV
110 120 130 140 150
FYFTMYISIS FLGLITIDRY QKTTRPFKTA NPNNLLGAKI LSVVIWAFMF
160 170 180 190 200
LISLPNMILT NRRPSDKTVK KCSFLKSEFG LVWHEIVNYV CQVIFWINFL
210 220 230 240 250
IVIVCYTLIT KELYKSYVRT RGAGKVPKKK VNIKVFIIIA VFFICFVPFH
260 270 280 290 300
FARIPYTLSQ TRDVFDCTAE NTLFYVKEST LWLTSLNACL DPFIYFFLCK
310 320 330
SFKNSLMSML RCSNSTSPPS HDNRKKGQDG SDPSEETPM
Length:339
Mass (Da):38,935
Last modified:October 3, 2006 - v1
Checksum:iCF232E3CD0DC3EF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02002656 Genomic DNA. No translation available.
BC122591 mRNA. Translation: AAI22592.1.
RefSeqiNP_001001174.2. NM_001001174.2.
XP_005201845.1. XM_005201788.3.
XP_005201846.1. XM_005201789.3.
XP_010799778.1. XM_010801476.2.
UniGeneiBt.29973.

Genome annotation databases

EnsembliENSBTAT00000044491; ENSBTAP00000041984; ENSBTAG00000015837.
ENSBTAT00000064076; ENSBTAP00000055434; ENSBTAG00000015837.
GeneIDi408007.
KEGGibta:408007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02002656 Genomic DNA. No translation available.
BC122591 mRNA. Translation: AAI22592.1.
RefSeqiNP_001001174.2. NM_001001174.2.
XP_005201845.1. XM_005201788.3.
XP_005201846.1. XM_005201789.3.
XP_010799778.1. XM_010801476.2.
UniGeneiBt.29973.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000044491; ENSBTAP00000041984; ENSBTAG00000015837.
ENSBTAT00000064076; ENSBTAP00000055434; ENSBTAG00000015837.
GeneIDi408007.
KEGGibta:408007.

Organism-specific databases

CTDi64805.

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
KOiK04298.
OMAiIKVFIII.
OrthoDBiEOG091G0B3H.
TreeFamiTF330969.

Enzyme and pathway databases

ReactomeiR-BTA-392170. ADP signalling through P2Y purinoceptor 12.
R-BTA-417957. P2Y receptors.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSBTAG00000015837.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0IIL0_BOVIN
AccessioniPrimary (citable) accession number: Q0IIL0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.