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Protein

N-alpha-acetyltransferase 50

Gene

NAA50

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 50 (EC:2.3.1.-)
Alternative name(s):
N-acetyltransferase 13
NatE catalytic subunit
Gene namesi
Name:NAA50
Synonyms:NAT13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169N-alpha-acetyltransferase 50PRO_0000284901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei34 – 341N6-acetyllysineBy similarity
Modified residuei37 – 371N6-acetyllysineBy similarity
Modified residuei110 – 1101PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0IIJ0.
PRIDEiQ0IIJ0.

Interactioni

Subunit structurei

Interacts with NAA15 and NAA11. Interacts with NAA35 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031032.

Structurei

3D structure databases

ProteinModelPortaliQ0IIJ0.
SMRiQ0IIJ0. Positions 4-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 9012Coenzyme A bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ0IIJ0.
OMAiSAIDFYQ.
OrthoDBiEOG7MWGZK.
TreeFamiTF314841.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY
60 70 80 90 100
FNDIAVGAVC CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC
110 120 130 140 150
EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL
160
QKNLKVPSGQ NADVQKTDN
Length:169
Mass (Da):19,398
Last modified:October 3, 2006 - v1
Checksum:i153A8021B74655CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122617 mRNA. Translation: AAI22618.1.
RefSeqiNP_001069218.1. NM_001075750.1.
XP_005201368.1. XM_005201311.2.
UniGeneiBt.55783.

Genome annotation databases

EnsembliENSBTAT00000031069; ENSBTAP00000031032; ENSBTAG00000007784.
GeneIDi517211.
KEGGibta:517211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122617 mRNA. Translation: AAI22618.1.
RefSeqiNP_001069218.1. NM_001075750.1.
XP_005201368.1. XM_005201311.2.
UniGeneiBt.55783.

3D structure databases

ProteinModelPortaliQ0IIJ0.
SMRiQ0IIJ0. Positions 4-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031032.

Proteomic databases

PaxDbiQ0IIJ0.
PRIDEiQ0IIJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000031069; ENSBTAP00000031032; ENSBTAG00000007784.
GeneIDi517211.
KEGGibta:517211.

Organism-specific databases

CTDi80218.

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ0IIJ0.
OMAiSAIDFYQ.
OrthoDBiEOG7MWGZK.
TreeFamiTF314841.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiNAA50_BOVIN
AccessioniPrimary (citable) accession number: Q0IIJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.