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Q0IIH7 (ST14_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Suppressor of tumorigenicity 14 protein homolog
EC=3.4.21.109
Alternative name(s):
Serine protease 14
Gene names
Name:ST14
Synonyms:PRSS14
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length855 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site By similarity.

Catalytic activity

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.

Subunit structure

Interacts with CDCP1. May interact with TMEFF1 By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 2 CUB domains.

Contains 4 LDL-receptor class A domains.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 855855Suppressor of tumorigenicity 14 protein homolog
PRO_0000285891

Regions

Topological domain1 – 5555Cytoplasmic Potential
Transmembrane56 – 7621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain77 – 855779Extracellular Potential
Domain214 – 334121CUB 1
Domain340 – 447108CUB 2
Domain452 – 48736LDL-receptor class A 1
Domain487 – 52438LDL-receptor class A 2
Domain524 – 56037LDL-receptor class A 3
Domain566 – 60338LDL-receptor class A 4
Domain615 – 854240Peptidase S1

Sites

Active site6561Charge relay system By similarity
Active site7111Charge relay system By similarity
Active site8051Charge relay system By similarity

Amino acid modifications

Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4891N-linked (GlcNAc...) Potential
Glycosylation7721N-linked (GlcNAc...) Potential
Disulfide bond214 ↔ 244 By similarity
Disulfide bond340 ↔ 366 By similarity
Disulfide bond397 ↔ 410 By similarity
Disulfide bond453 ↔ 464 By similarity
Disulfide bond459 ↔ 477 By similarity
Disulfide bond471 ↔ 486 By similarity
Disulfide bond488 ↔ 501 By similarity
Disulfide bond496 ↔ 514 By similarity
Disulfide bond508 ↔ 523 By similarity
Disulfide bond525 ↔ 537 By similarity
Disulfide bond532 ↔ 550 By similarity
Disulfide bond544 ↔ 559 By similarity
Disulfide bond567 ↔ 579 By similarity
Disulfide bond574 ↔ 593 By similarity
Disulfide bond587 ↔ 602 By similarity
Disulfide bond641 ↔ 657 By similarity
Disulfide bond776 ↔ 790 By similarity
Disulfide bond801 ↔ 830 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IIH7 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: DA6E866AAB874F4C

FASTA85594,964
        10         20         30         40         50         60 
MKSERARRGA GGSGDLGAGF KYTSRPENMN GCEEGVEFLP ANNSSKVEKG GPRRWVVLMA 

        70         80         90        100        110        120 
VLAAFLALSL LAGLLAWHFQ DRNVRVQKIF NGYLSVRNEN FLDAYENSNS TEFANLAKKV 

       130        140        150        160        170        180 
KEALKFLYSG IPVLGPYHKT STVTAFSEGS VIAYYWSEFD IPKHLVKEAE QAMAEKRMVT 

       190        200        210        220        230        240 
VPPRARSMSS FVMTSVVAFP SDPRIIQNTQ DNSCSFALHA QGSEPIRFST PGFPDSPYPS 

       250        260        270        280        290        300 
HARCQWTLRG DADSVLSLTF RSFDVATCDE RGSDLVTVYD TLSPVEPRAV VQLCGTYPPS 

       310        320        330        340        350        360 
YNLTFLSSQN VLLITLVTST ERRHPGFEAV FFQLPRMSSC GGYLRAAQGT FNSPYYPGHY 

       370        380        390        400        410        420 
PPNINCTWHI EVPDNKNVKV RFKAFFLQEP NVPVGSCTKD YVEINGEKYC GERPQFVASS 

       430        440        450        460        470        480 
RNNKITVHFH SDQSYTDTGF LAEFLSFDAR DPCPGSFMCN TGRCIRKELR CDGWADCTDY 

       490        500        510        520        530        540 
SDELDCKCNA TYQFTCRDKF CKPLFWVCDS VKDCEDGSDE EGCSCPPNTF KCGNGKCLPQ 

       550        560        570        580        590        600 
SQQCDRKDDC GDGSDEAKCQ DGKAVPCTEH THRCLNGLCV DKSNPQCDGN EDCTDGSDEK 

       610        620        630        640        650        660 
DCDCGRRSFT RQSRVVGGEN SDQGEWPWQV SLHAQGHGHL CGASLISPSW MISAAHCFVD 

       670        680        690        700        710        720 
DRGFRYSEHS VWTAFLGLHD QSKRNAPGVQ ERGLQRIIKH PFFNDFTFDY DIALLQLDRP 

       730        740        750        760        770        780 
VEYSATIRPI CLPAADYTFP TGKAIWVTGW GHTQEAGQGA MILQKGEIRV INQTTCEHLL 

       790        800        810        820        830        840 
PQQITPRMIC VGYLSGGVDA CQGDSGGPLS SPEEDGRMFQ AGVVSWGEGC AQRNKPGVYT 

       850 
RLPVFRDWIK AQIGV

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC122638 mRNA. Translation: AAI22639.1.
IPIIPI00689165.
RefSeqNP_001070006.1. NM_001076538.1.
UniGeneBt.26715.

3D structure databases

ProteinModelPortalQ0IIH7.
SMRQ0IIH7. Positions 615-855.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000026272.

Protein family/group databases

MEROPSS01.302.

Proteomic databases

PRIDEQ0IIH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID767617.
KEGGbta:767617.

Organism-specific databases

CTD6768.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000136851.
HOVERGENHBG012556.
InParanoidQ0IIH7.
KOK08670.
OrthoDBEOG43FGW9.

Family and domain databases

Gene3D2.60.120.290. 2 hits.
4.10.400.10. 4 hits.
InterProIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR017051. Peptidase_S1A_matripase.
IPR000082. SEA.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 4 hits.
PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFPIRSF036370. ST14. 1 hit.
SMARTSM00042. CUB. 2 hits.
SM00192. LDLa. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF49854. CUB. 2 hits.
SSF57424. LDL_rcpt_classA_cys-rich. 4 hits.
SSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20918022.

Entry information

Entry nameST14_BOVIN
AccessionPrimary (citable) accession number: Q0IIH7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 3, 2006
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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