ID   K6PF_BOVIN              Reviewed;         779 AA.
AC   Q0IIG5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=6-phosphofructokinase, muscle type;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphofructokinase 1;
DE   AltName: Full=Phosphohexokinase;
DE   AltName: Full=Phosphofructo-1-kinase isozyme A;
DE            Short=PFK-A;
DE            Short=Phosphofructokinase-M;
GN   Name=PFKM;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- ENZYME REGULATION: Allosteric enzyme activated by ADP, AMP, or
CC       fructose bisphosphate and inhibited by ATP or citrate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family. Two domains
CC       subfamily.
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DR   EMBL; BC122655; AAI22656.1; -; mRNA.
DR   IPI; IPI00685357; -.
DR   RefSeq; NP_001068736.1; -.
DR   UniGene; Bt.61411; -.
DR   Ensembl; ENSBTAG00000000286; Bos taurus.
DR   GeneID; 506544; -.
DR   KEGG; bta:506544; -.
DR   HOVERGEN; Q0IIG5; -.
DR   BRENDA; 2.7.1.11; 251.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR009161; 6-phosphofructokinase_euk.
DR   InterPro; IPR000023; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   Pfam; PF00365; PFK; 2.
DR   PIRSF; PIRSF000533; ATP_PFK_euk; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   ProDom; PD000707; Ppfruckinase; 2.
DR   TIGRFAMs; TIGR02478; 6PF1K_euk; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 2.
PE   2: Evidence at transcript level;
KW   Allosteric enzyme; ATP-binding; Glycolysis; Kinase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat;
KW   Transferase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    779       6-phosphofructokinase, muscle type.
FT                                /FTId=PRO_0000284438.
FT   REPEAT        2    401       Approximate.
FT   REPEAT      402    779       Approximate.
FT   NP_BIND      34     38       ATP (By similarity).
FT   NP_BIND     192    196       ATP (By similarity).
FT   NP_BIND     209    225       ATP (By similarity).
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   METAL       223    223       Magnesium; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     200    200       Substrate (By similarity).
FT   BINDING     291    291       Substrate (By similarity).
FT   BINDING     297    297       Substrate (By similarity).
FT   BINDING     300    300       Substrate (By similarity).
FT   MOD_RES       2      2       Phosphothreonine (By similarity).
FT   MOD_RES     774    774       Phosphoserine (By similarity).
SQ   SEQUENCE   779 AA;  85294 MW;  BBA2D207ADD079EE CRC64;
     MTHEHHAAKT LGIGKAIAVL TSGGDAQGMN AAVRAVVRVG IYTGARVFFV HEGYQGLVDG
     GDNIREATWE SVSMMLQLGG TVIGSARCKD FREREGRLRA AHNLVKRGIT NLCVIGGDGS
     LTGADTFRSE WSDLLSDLQK SGKITAEEAT KSSYLNIVGL VGSIDNDFCG TDMTIGTDSA
     LHRIIEIVDA ITTTAQSHQR TFVLEVMGRH CGYLALVTSL SCGADWVFIP ECPPDDDWEE
     HLCRRLSETR NRGSRLNIII VAEGAIDKNG KPITSEDIKN LVVKRLGYDT RVTVLGHVQR
     GGTPSAFDRI LGSRMGVEAV MALLEGTPDT PACVVSLSGN QAVRLPLMEC VQVTKDVTRA
     MDERRFDEAL KLRGRSFMNN WEVYKLLAHV RPPKSKSGSH TVAVMNVGAP AAGMNAAVRS
     TVRIGLIQGN RMLVVHDGFE GLAKGQIEEA GWSYVGGWTG QGGSKLGTKR TLPKKSFEQI
     SANITKFNIQ GLVIIGGFEA YTGGLELMEG RKQYDELCIP FVVIPATVSN NVPGSDFSVG
     ADTALNTICM TCDRIKQSAA GTKRRVFIIE TMGGYCGYLA TMAGLAAGAD AAYIFEDPFT
     IRDLQVNVEH LVQKMKTTVK RGLVLRNEKC NENYTTDFIF NLYSEEGKGI FDSRKNVLGH
     MQQGGSPTPF DRNFATKMGA KAMNWMSGKI KESYRNGRIF ANSPDSGCVL GMRKRALVFQ
     PVTELKEQTD FEHRIPKEQW WLKLRPILKI LAKYEIDLDT SEHAHLEHIS RKRSGEANV
//