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Q0IIF9

- CP2U1_BOVIN

UniProt

Q0IIF9 - CP2U1_BOVIN

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Protein

Cytochrome P450 2U1

Gene
CYP2U1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2U1 (EC:1.14.14.1)
Gene namesi
Name:CYP2U1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Reviewed predictionAdd
BLAST
Transmembranei261 – 28121Helical; Reviewed predictionAdd
BLAST
Transmembranei342 – 36221Helical; Reviewed predictionAdd
BLAST
Transmembranei495 – 51521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Cytochrome P450 2U1PRO_0000291755Add
BLAST

Proteomic databases

PRIDEiQ0IIF9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017246.

Structurei

3D structure databases

ProteinModelPortaliQ0IIF9.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ0IIF9.
KOiK07422.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIF9-1 [UniParc]FASTAAdd to Basket

« Hide

MASPGLPQPP TEDAAWPLRL LHAPPGLLRL DPTGGALLLL VLAALLGWSW    50
LWRLPERGIP PGPAPWPVVG NFGFVLLPRF LRRKSWPYRR ARNGGMNASG 100
QGVQLLLADL GRVYGNIFSF LIGHYLVVVL NDFHSVREAL VQQAEVFSDR 150
PRVPLTSIMT KGKGIVFAHY GPVWRQQRKF SHSTLRHFGL GKLSLEPKII 200
EEFRYVKEEM QKHGDAPFNP FPIVNNAVSN IICSLCFGRR FDYTNSEFKQ 250
MLNFMSRALE VCLNTQLLLV NICSWLYYLP FGPFKELRQI EKDLTLFLKK 300
IIKDHRESLD VENPQDFIDM YLLHVEEEKK NNSNSGFDED YLFYIIGDLF 350
IAGTDTTTNS LLWCLLYMSL HPNIQEKIHE EIARVIGADR APSLTDKAQM 400
PYTEATIMEV QRLSTVVPLS IPHMTSEKTV LQGFTIPKGT IILPNLWSVH 450
RDPAIWEKPN DFYPDRFLDD QGQLIKKETF IPFGIGKRVC MGEQLAKMEL 500
FLMFVSLMQS FTFVLPKDSK PILTGKYGLT LAPHPFNIII SKR 543
Length:543
Mass (Da):61,997
Last modified:October 3, 2006 - v1
Checksum:i00DEC2B84EC1D93C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122663 mRNA. Translation: AAI22664.1.
RefSeqiNP_001069518.1. NM_001076050.2.
UniGeneiBt.56804.

Genome annotation databases

GeneIDi535227.
KEGGibta:535227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122663 mRNA. Translation: AAI22664.1 .
RefSeqi NP_001069518.1. NM_001076050.2.
UniGenei Bt.56804.

3D structure databases

ProteinModelPortali Q0IIF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017246.

Proteomic databases

PRIDEi Q0IIF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 535227.
KEGGi bta:535227.

Organism-specific databases

CTDi 113612.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q0IIF9.
KOi K07422.

Miscellaneous databases

NextBioi 20876667.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiCP2U1_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 3, 2006
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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