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Q0IIF9

- CP2U1_BOVIN

UniProt

Q0IIF9 - CP2U1_BOVIN

Protein

Cytochrome P450 2U1

Gene

CYP2U1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi490 – 4901Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2U1 (EC:1.14.14.1)
    Gene namesi
    Name:CYP2U1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Cytochrome P450 2U1PRO_0000291755Add
    BLAST

    Proteomic databases

    PRIDEiQ0IIF9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IIF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ0IIF9.
    KOiK07422.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0IIF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPGLPQPP TEDAAWPLRL LHAPPGLLRL DPTGGALLLL VLAALLGWSW    50
    LWRLPERGIP PGPAPWPVVG NFGFVLLPRF LRRKSWPYRR ARNGGMNASG 100
    QGVQLLLADL GRVYGNIFSF LIGHYLVVVL NDFHSVREAL VQQAEVFSDR 150
    PRVPLTSIMT KGKGIVFAHY GPVWRQQRKF SHSTLRHFGL GKLSLEPKII 200
    EEFRYVKEEM QKHGDAPFNP FPIVNNAVSN IICSLCFGRR FDYTNSEFKQ 250
    MLNFMSRALE VCLNTQLLLV NICSWLYYLP FGPFKELRQI EKDLTLFLKK 300
    IIKDHRESLD VENPQDFIDM YLLHVEEEKK NNSNSGFDED YLFYIIGDLF 350
    IAGTDTTTNS LLWCLLYMSL HPNIQEKIHE EIARVIGADR APSLTDKAQM 400
    PYTEATIMEV QRLSTVVPLS IPHMTSEKTV LQGFTIPKGT IILPNLWSVH 450
    RDPAIWEKPN DFYPDRFLDD QGQLIKKETF IPFGIGKRVC MGEQLAKMEL 500
    FLMFVSLMQS FTFVLPKDSK PILTGKYGLT LAPHPFNIII SKR 543
    Length:543
    Mass (Da):61,997
    Last modified:October 3, 2006 - v1
    Checksum:i00DEC2B84EC1D93C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122663 mRNA. Translation: AAI22664.1.
    RefSeqiNP_001069518.1. NM_001076050.2.
    UniGeneiBt.56804.

    Genome annotation databases

    GeneIDi535227.
    KEGGibta:535227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122663 mRNA. Translation: AAI22664.1 .
    RefSeqi NP_001069518.1. NM_001076050.2.
    UniGenei Bt.56804.

    3D structure databases

    ProteinModelPortali Q0IIF9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017246.

    Proteomic databases

    PRIDEi Q0IIF9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 535227.
    KEGGi bta:535227.

    Organism-specific databases

    CTDi 113612.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q0IIF9.
    KOi K07422.

    Miscellaneous databases

    NextBioi 20876667.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiCP2U1_BOVIN
    AccessioniPrimary (citable) accession number: Q0IIF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3