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Q0IIF9 (CP2U1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2U1

EC=1.14.14.1
Gene names
Name:CYP2U1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Microsome membrane By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Cytochrome P450 2U1
PRO_0000291755

Regions

Transmembrane32 – 5221Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane495 – 51521Helical; Potential

Sites

Metal binding4901Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IIF9 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 00DEC2B84EC1D93C

FASTA54361,997
        10         20         30         40         50         60 
MASPGLPQPP TEDAAWPLRL LHAPPGLLRL DPTGGALLLL VLAALLGWSW LWRLPERGIP 

        70         80         90        100        110        120 
PGPAPWPVVG NFGFVLLPRF LRRKSWPYRR ARNGGMNASG QGVQLLLADL GRVYGNIFSF 

       130        140        150        160        170        180 
LIGHYLVVVL NDFHSVREAL VQQAEVFSDR PRVPLTSIMT KGKGIVFAHY GPVWRQQRKF 

       190        200        210        220        230        240 
SHSTLRHFGL GKLSLEPKII EEFRYVKEEM QKHGDAPFNP FPIVNNAVSN IICSLCFGRR 

       250        260        270        280        290        300 
FDYTNSEFKQ MLNFMSRALE VCLNTQLLLV NICSWLYYLP FGPFKELRQI EKDLTLFLKK 

       310        320        330        340        350        360 
IIKDHRESLD VENPQDFIDM YLLHVEEEKK NNSNSGFDED YLFYIIGDLF IAGTDTTTNS 

       370        380        390        400        410        420 
LLWCLLYMSL HPNIQEKIHE EIARVIGADR APSLTDKAQM PYTEATIMEV QRLSTVVPLS 

       430        440        450        460        470        480 
IPHMTSEKTV LQGFTIPKGT IILPNLWSVH RDPAIWEKPN DFYPDRFLDD QGQLIKKETF 

       490        500        510        520        530        540 
IPFGIGKRVC MGEQLAKMEL FLMFVSLMQS FTFVLPKDSK PILTGKYGLT LAPHPFNIII 


SKR 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122663 mRNA. Translation: AAI22664.1.
RefSeqNP_001069518.1. NM_001076050.2.
UniGeneBt.56804.

3D structure databases

ProteinModelPortalQ0IIF9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000017246.

Proteomic databases

PRIDEQ0IIF9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID535227.
KEGGbta:535227.

Organism-specific databases

CTD113612.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ0IIF9.
KOK07422.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876667.

Entry information

Entry nameCP2U1_BOVIN
AccessionPrimary (citable) accession number: Q0IIF9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 3, 2006
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families