Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0IIF9

- CP2U1_BOVIN

UniProt

Q0IIF9 - CP2U1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 2U1

Gene

CYP2U1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2U1 (EC:1.14.14.1)
Gene namesi
Name:CYP2U1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Cytochrome P450 2U1PRO_0000291755Add
BLAST

Proteomic databases

PRIDEiQ0IIF9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017246.

Structurei

3D structure databases

ProteinModelPortaliQ0IIF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ0IIF9.
KOiK07422.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPGLPQPP TEDAAWPLRL LHAPPGLLRL DPTGGALLLL VLAALLGWSW
60 70 80 90 100
LWRLPERGIP PGPAPWPVVG NFGFVLLPRF LRRKSWPYRR ARNGGMNASG
110 120 130 140 150
QGVQLLLADL GRVYGNIFSF LIGHYLVVVL NDFHSVREAL VQQAEVFSDR
160 170 180 190 200
PRVPLTSIMT KGKGIVFAHY GPVWRQQRKF SHSTLRHFGL GKLSLEPKII
210 220 230 240 250
EEFRYVKEEM QKHGDAPFNP FPIVNNAVSN IICSLCFGRR FDYTNSEFKQ
260 270 280 290 300
MLNFMSRALE VCLNTQLLLV NICSWLYYLP FGPFKELRQI EKDLTLFLKK
310 320 330 340 350
IIKDHRESLD VENPQDFIDM YLLHVEEEKK NNSNSGFDED YLFYIIGDLF
360 370 380 390 400
IAGTDTTTNS LLWCLLYMSL HPNIQEKIHE EIARVIGADR APSLTDKAQM
410 420 430 440 450
PYTEATIMEV QRLSTVVPLS IPHMTSEKTV LQGFTIPKGT IILPNLWSVH
460 470 480 490 500
RDPAIWEKPN DFYPDRFLDD QGQLIKKETF IPFGIGKRVC MGEQLAKMEL
510 520 530 540
FLMFVSLMQS FTFVLPKDSK PILTGKYGLT LAPHPFNIII SKR
Length:543
Mass (Da):61,997
Last modified:October 3, 2006 - v1
Checksum:i00DEC2B84EC1D93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122663 mRNA. Translation: AAI22664.1.
RefSeqiNP_001069518.1. NM_001076050.2.
UniGeneiBt.56804.

Genome annotation databases

GeneIDi535227.
KEGGibta:535227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122663 mRNA. Translation: AAI22664.1 .
RefSeqi NP_001069518.1. NM_001076050.2.
UniGenei Bt.56804.

3D structure databases

ProteinModelPortali Q0IIF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017246.

Proteomic databases

PRIDEi Q0IIF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 535227.
KEGGi bta:535227.

Organism-specific databases

CTDi 113612.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q0IIF9.
KOi K07422.

Miscellaneous databases

NextBioi 20876667.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiCP2U1_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 3, 2006
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3