ID   UBP14_BOVIN             Reviewed;         494 AA.
AC   Q0IIF7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Ubiquitin carboxyl-terminal hydrolase 14;
DE            EC=3.1.2.15;
DE   AltName: Full=Ubiquitin thioesterase 14;
DE   AltName: Full=Ubiquitin-specific-processing protease 14;
DE   AltName: Full=Deubiquitinating enzyme 14;
GN   Name=USP14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Ubiquitin C-terminal thioester + H(2)O =
CC       ubiquitin + a thiol.
CC   -!- SUBUNIT: Homodimer (Potential).
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC   -!- SIMILARITY: Contains 1 ubiquitin-like domain.
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DR   EMBL; BC122666; AAI22667.1; -; mRNA.
DR   IPI; IPI00690054; -.
DR   RefSeq; NP_001068657.1; -.
DR   UniGene; Bt.20599; -.
DR   SMR; Q0IIF7; 6-86, 101-483.
DR   MEROPS; C19.015; -.
DR   Ensembl; ENSBTAG00000019214; Bos taurus.
DR   GeneID; 505106; -.
DR   KEGG; bta:505106; -.
DR   HOVERGEN; Q0IIF7; -.
DR   BRENDA; 3.1.2.15; 251.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004221; F:ubiquitin thiolesterase activity; IEA:EC.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR018200; Pept_C19ubi-hydrolase_C_CS.
DR   InterPro; IPR001394; Peptidase_C19.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00443; UCH; 1.
DR   SMART; SM00213; UBQ; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   PROSITE; PS00972; UCH_2_1; 1.
DR   PROSITE; PS00973; UCH_2_2; 1.
DR   PROSITE; PS50235; UCH_2_3; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Phosphoprotein; Protease; Thiol protease;
KW   Ubl conjugation pathway.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    494       Ubiquitin carboxyl-terminal hydrolase 14.
FT                                /FTId=PRO_0000268845.
FT   DOMAIN        4     80       Ubiquitin-like.
FT   ACT_SITE    114    114       By similarity.
FT   ACT_SITE    426    426       By similarity.
FT   ACT_SITE    435    435       By similarity.
FT   MOD_RES     136    136       Phosphotyrosine (By similarity).
FT   MOD_RES     143    143       Phosphoserine (By similarity).
SQ   SEQUENCE   494 AA;  56013 MW;  089AE0AC7790CCC5 CRC64;
     MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN
     IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV
     QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH
     MAFPQFAEKG EQGQYLQQDA NECWVQMMRV LQQKLEAIED DTVKETDSSS ASAVTPSKKK
     SLIDQFFGVE FETTMKCTES EEEEVTKGKE SQLQLSCFIN QEVKYLFTGL KLRLQEEITK
     QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDVYELCT
     PELQEKMVSF RSKFKDLEDK KVNQQPKTGD KDSSPQKEVK YEPFSFADDI GSNNCGYYDL
     QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY
     GPRRVEIMEE ESEQ
//