Reviewed, UniProtKB/Swiss-Prot Q0IIF7 (UBP14_BOVIN)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 14
    Ubiquitin-specific-processing protease 14
    Deubiquitinating enzyme 14

Gene names

Name:

USP14

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
Subunit structure	Homodimer Potential.
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 494	493	Ubiquitin carboxyl-terminal hydrolase 14		PRO_0000268845
Regions
	Domain	4 – 80	77	Ubiquitin-like
Sites
	Active site	114	1	By similarity
	Active site	426	1	By similarity
	Active site	435	1	By similarity
Amino acid modifications
	Modified residue	136	1	Phosphotyrosine By similarity
	Modified residue	143	1	Phosphoserine By similarity
	Modified residue	291	1	N6-acetyllysine By similarity
	Modified residue	313	1	N6-acetyllysine By similarity
	Modified residue	449	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0IIF7-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 089AE0AC7790CCC5	FASTA	494	56,013
	10 20 30 40 50 60 MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 70 80 90 100 110 120 IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 130 140 150 160 170 180 QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH 190 200 210 220 230 240 MAFPQFAEKG EQGQYLQQDA NECWVQMMRV LQQKLEAIED DTVKETDSSS ASAVTPSKKK 250 260 270 280 290 300 SLIDQFFGVE FETTMKCTES EEEEVTKGKE SQLQLSCFIN QEVKYLFTGL KLRLQEEITK 310 320 330 340 350 360 QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDVYELCT 370 380 390 400 410 420 PELQEKMVSF RSKFKDLEDK KVNQQPKTGD KDSSPQKEVK YEPFSFADDI GSNNCGYYDL 430 440 450 460 470 480 QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY 490 GPRRVEIMEE ESEQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC122666 mRNA. Translation: AAI22667.1.
IPI	IPI00690054.
RefSeq	NP_001068657.1.
UniGene	Bt.20599
3D structure databases
SMR	Q0IIF7. Positions 6-86, 98-483.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0IIF7.
Protein family/group databases
MEROPS	C19.015.
Genome annotation databases
Ensembl	ENSBTAT00000025580; ENSBTAP00000025580; ENSBTAG00000019214; Bos taurus. [Genome view]
GeneID	505106.
KEGG	bta:505106.
Organism-specific databases
CTD	505106.
Phylogenomic databases
eggNOG	maNOG07913.
HOVERGEN	Q0IIF7.
InParanoid	Q0IIF7.
PhylomeDB	Q0IIF7.
Enzyme and pathway databases
BRENDA	3.1.2.15. 251.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR000626. Ubiquitin. IPR019954. Ubiquitin_CS. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP14_BOVIN

Accession

Primary (citable) accession number: Q0IIF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 29 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)