Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0IIF0

- ILKAP_BOVIN

UniProt

Q0IIF0 - ILKAP_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Gene

ILKAP

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Manganese 1By similarity
Metal bindingi130 – 1301Manganese 2By similarity
Metal bindingi131 – 1311Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi304 – 3041Manganese 2By similarity
Metal bindingi359 – 3591Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin-linked kinase-associated serine/threonine phosphatase 2C (EC:3.1.3.16)
Short name:
ILKAP
Gene namesi
Name:ILKAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Integrin-linked kinase-associated serine/threonine phosphatase 2CPRO_0000272270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei188 – 1881N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ0IIF0.

Interactioni

Subunit structurei

Interacts with ILK.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013428.

Structurei

3D structure databases

ProteinModelPortaliQ0IIF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 368264PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000233896.
HOVERGENiHBG054286.
InParanoidiQ0IIF0.
KOiK17500.
OMAiDIKRCQL.
OrthoDBiEOG7Z95NF.
TreeFamiTF313513.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN
60 70 80 90 100
EGKGAKRKAS DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ
110 120 130 140 150
DAHVILNDIT AECQPPSALV TRVSYFAVFD GHGGIRASKF AAQNLHQNLI
160 170 180 190 200
RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF LKQASSQKPA WKDGSTATCV
210 220 230 240 250
LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP TQYEERMRIQ
260 270 280 290 300
KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL
310 320 330 340 350
LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN
360 370
KAVQRGSADN VTVMVVRIGL
Length:370
Mass (Da):40,622
Last modified:October 3, 2006 - v1
Checksum:i3435602459B36030
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122677 mRNA. Translation: AAI22678.1.
RefSeqiNP_001069123.1. NM_001075655.1.
UniGeneiBt.35583.

Genome annotation databases

EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneIDi514223.
KEGGibta:514223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC122677 mRNA. Translation: AAI22678.1 .
RefSeqi NP_001069123.1. NM_001075655.1.
UniGenei Bt.35583.

3D structure databases

ProteinModelPortali Q0IIF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000013428.

Proteomic databases

PRIDEi Q0IIF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013428 ; ENSBTAP00000013428 ; ENSBTAG00000010176 .
GeneIDi 514223.
KEGGi bta:514223.

Organism-specific databases

CTDi 80895.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000114971.
HOGENOMi HOG000233896.
HOVERGENi HBG054286.
InParanoidi Q0IIF0.
KOi K17500.
OMAi DIKRCQL.
OrthoDBi EOG7Z95NF.
TreeFami TF313513.

Miscellaneous databases

NextBioi 20871237.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiILKAP_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3