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Protein

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Gene

ILKAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Manganese 1By similarity
Metal bindingi130 – 1301Manganese 2By similarity
Metal bindingi131 – 1311Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi304 – 3041Manganese 2By similarity
Metal bindingi359 – 3591Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin-linked kinase-associated serine/threonine phosphatase 2C (EC:3.1.3.16)
Short name:
ILKAP
Gene namesi
Name:ILKAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Integrin-linked kinase-associated serine/threonine phosphatase 2CPRO_0000272270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei188 – 1881N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ0IIF0.

Interactioni

Subunit structurei

Interacts with ILK.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013428.

Structurei

3D structure databases

ProteinModelPortaliQ0IIF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 368283PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
HOVERGENiHBG054286.
InParanoidiQ0IIF0.
KOiK17500.
OMAiPDIKRCQ.
OrthoDBiEOG7Z95NF.
TreeFamiTF313513.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN
60 70 80 90 100
EGKGAKRKAS DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ
110 120 130 140 150
DAHVILNDIT AECQPPSALV TRVSYFAVFD GHGGIRASKF AAQNLHQNLI
160 170 180 190 200
RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF LKQASSQKPA WKDGSTATCV
210 220 230 240 250
LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP TQYEERMRIQ
260 270 280 290 300
KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL
310 320 330 340 350
LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN
360 370
KAVQRGSADN VTVMVVRIGL
Length:370
Mass (Da):40,622
Last modified:October 2, 2006 - v1
Checksum:i3435602459B36030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122677 mRNA. Translation: AAI22678.1.
RefSeqiNP_001069123.1. NM_001075655.1.
UniGeneiBt.35583.

Genome annotation databases

EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneIDi514223.
KEGGibta:514223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122677 mRNA. Translation: AAI22678.1.
RefSeqiNP_001069123.1. NM_001075655.1.
UniGeneiBt.35583.

3D structure databases

ProteinModelPortaliQ0IIF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013428.

Proteomic databases

PRIDEiQ0IIF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneIDi514223.
KEGGibta:514223.

Organism-specific databases

CTDi80895.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
HOVERGENiHBG054286.
InParanoidiQ0IIF0.
KOiK17500.
OMAiPDIKRCQ.
OrthoDBiEOG7Z95NF.
TreeFamiTF313513.

Miscellaneous databases

NextBioi20871237.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiILKAP_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2007
Last sequence update: October 2, 2006
Last modified: March 31, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.