Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0IIF0 (ILKAP_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin-linked kinase-associated serine/threonine phosphatase 2C

Short name=ILKAP
EC=3.1.3.16
Gene names
Name:ILKAP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Interacts with ILK By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Integrin-linked kinase-associated serine/threonine phosphatase 2C
PRO_0000272270

Regions

Domain105 – 368264PP2C-like

Sites

Metal binding1301Manganese 1 By similarity
Metal binding1301Manganese 2 By similarity
Metal binding1311Manganese 1; via carbonyl oxygen By similarity
Metal binding3041Manganese 2 By similarity
Metal binding3591Manganese 2 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue131Phosphoserine By similarity
Modified residue1881N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IIF0 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 3435602459B36030

FASTA37040,622
        10         20         30         40         50         60 
MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN EGKGAKRKAS 

        70         80         90        100        110        120 
DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ DAHVILNDIT AECQPPSALV 

       130        140        150        160        170        180 
TRVSYFAVFD GHGGIRASKF AAQNLHQNLI RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF 

       190        200        210        220        230        240 
LKQASSQKPA WKDGSTATCV LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP 

       250        260        270        280        290        300 
TQYEERMRIQ KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL 

       310        320        330        340        350        360 
LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN KAVQRGSADN 

       370 
VTVMVVRIGL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122677 mRNA. Translation: AAI22678.1.
RefSeqNP_001069123.1. NM_001075655.1.
UniGeneBt.35583.

3D structure databases

ProteinModelPortalQ0IIF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000013428.

Proteomic databases

PRIDEQ0IIF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneID514223.
KEGGbta:514223.

Organism-specific databases

CTD80895.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00740000114971.
HOGENOMHOG000233896.
HOVERGENHBG054286.
KOK17500.
OMADIKRCQL.
OrthoDBEOG7Z95NF.
TreeFamTF313513.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871237.

Entry information

Entry nameILKAP_BOVIN
AccessionPrimary (citable) accession number: Q0IIF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families