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Q0IIF0

- ILKAP_BOVIN

UniProt

Q0IIF0 - ILKAP_BOVIN

Protein

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Gene

ILKAP

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi130 – 1301Manganese 1By similarity
    Metal bindingi130 – 1301Manganese 2By similarity
    Metal bindingi131 – 1311Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi304 – 3041Manganese 2By similarity
    Metal bindingi359 – 3591Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin-linked kinase-associated serine/threonine phosphatase 2C (EC:3.1.3.16)
    Short name:
    ILKAP
    Gene namesi
    Name:ILKAP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Integrin-linked kinase-associated serine/threonine phosphatase 2CPRO_0000272270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei188 – 1881N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ0IIF0.

    Interactioni

    Subunit structurei

    Interacts with ILK.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IIF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 368264PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000233896.
    HOVERGENiHBG054286.
    KOiK17500.
    OMAiDIKRCQL.
    OrthoDBiEOG7Z95NF.
    TreeFamiTF313513.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0IIF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN    50
    EGKGAKRKAS DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ 100
    DAHVILNDIT AECQPPSALV TRVSYFAVFD GHGGIRASKF AAQNLHQNLI 150
    RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF LKQASSQKPA WKDGSTATCV 200
    LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP TQYEERMRIQ 250
    KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL 300
    LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN 350
    KAVQRGSADN VTVMVVRIGL 370
    Length:370
    Mass (Da):40,622
    Last modified:October 3, 2006 - v1
    Checksum:i3435602459B36030
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122677 mRNA. Translation: AAI22678.1.
    RefSeqiNP_001069123.1. NM_001075655.1.
    UniGeneiBt.35583.

    Genome annotation databases

    EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
    GeneIDi514223.
    KEGGibta:514223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122677 mRNA. Translation: AAI22678.1 .
    RefSeqi NP_001069123.1. NM_001075655.1.
    UniGenei Bt.35583.

    3D structure databases

    ProteinModelPortali Q0IIF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013428.

    Proteomic databases

    PRIDEi Q0IIF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013428 ; ENSBTAP00000013428 ; ENSBTAG00000010176 .
    GeneIDi 514223.
    KEGGi bta:514223.

    Organism-specific databases

    CTDi 80895.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000233896.
    HOVERGENi HBG054286.
    KOi K17500.
    OMAi DIKRCQL.
    OrthoDBi EOG7Z95NF.
    TreeFami TF313513.

    Miscellaneous databases

    NextBioi 20871237.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiILKAP_BOVIN
    AccessioniPrimary (citable) accession number: Q0IIF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3