Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Gene

ILKAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Manganese 1By similarity1
Metal bindingi130Manganese 2By similarity1
Metal bindingi131Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi304Manganese 2By similarity1
Metal bindingi359Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin-linked kinase-associated serine/threonine phosphatase 2C (EC:3.1.3.16)
Short name:
ILKAP
Gene namesi
Name:ILKAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002722701 – 370Integrin-linked kinase-associated serine/threonine phosphatase 2CAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei188N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0IIF0.
PRIDEiQ0IIF0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010176.

Interactioni

Subunit structurei

Interacts with ILK.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013428.

Structurei

3D structure databases

ProteinModelPortaliQ0IIF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 368PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000233896.
HOVERGENiHBG054286.
InParanoidiQ0IIF0.
KOiK17500.
OMAiPDIKRCQ.
OrthoDBiEOG091G0L5M.
TreeFamiTF313513.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN
60 70 80 90 100
EGKGAKRKAS DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ
110 120 130 140 150
DAHVILNDIT AECQPPSALV TRVSYFAVFD GHGGIRASKF AAQNLHQNLI
160 170 180 190 200
RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF LKQASSQKPA WKDGSTATCV
210 220 230 240 250
LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP TQYEERMRIQ
260 270 280 290 300
KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL
310 320 330 340 350
LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN
360 370
KAVQRGSADN VTVMVVRIGL
Length:370
Mass (Da):40,622
Last modified:October 3, 2006 - v1
Checksum:i3435602459B36030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122677 mRNA. Translation: AAI22678.1.
RefSeqiNP_001069123.1. NM_001075655.1.
UniGeneiBt.35583.

Genome annotation databases

EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneIDi514223.
KEGGibta:514223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122677 mRNA. Translation: AAI22678.1.
RefSeqiNP_001069123.1. NM_001075655.1.
UniGeneiBt.35583.

3D structure databases

ProteinModelPortaliQ0IIF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013428.

Proteomic databases

PaxDbiQ0IIF0.
PRIDEiQ0IIF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013428; ENSBTAP00000013428; ENSBTAG00000010176.
GeneIDi514223.
KEGGibta:514223.

Organism-specific databases

CTDi80895.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000233896.
HOVERGENiHBG054286.
InParanoidiQ0IIF0.
KOiK17500.
OMAiPDIKRCQ.
OrthoDBiEOG091G0L5M.
TreeFamiTF313513.

Gene expression databases

BgeeiENSBTAG00000010176.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILKAP_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.