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Protein

SHC-transforming protein 1

Gene

SHC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Growth regulation

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-1250196. SHC1 events in ERBB2 signaling.
R-BTA-1250347. SHC1 events in ERBB4 signaling.
R-BTA-167044. Signalling to RAS.
R-BTA-180336. SHC1 events in EGFR signaling.
R-BTA-210993. Tie2 Signaling.
R-BTA-2424491. DAP12 signaling.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-2871809. FCERI mediated Ca+2 mobilization.
R-BTA-354192. Integrin alphaIIb beta3 signaling.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-451927. Interleukin-2 signaling.
R-BTA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-BTA-5654688. SHC-mediated cascade:FGFR1.
R-BTA-5654699. SHC-mediated cascade:FGFR2.
R-BTA-5654704. SHC-mediated cascade:FGFR3.
R-BTA-5654719. SHC-mediated cascade:FGFR4.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-74749. Signal attenuation.
R-BTA-74751. Insulin receptor signalling cascade.
R-BTA-8851805. MET activates RAS signaling.
R-BTA-8853659. RET signaling.
R-BTA-912526. Interleukin receptor SHC signaling.
R-BTA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 1
Alternative name(s):
Src homology 2 domain-containing-transforming protein C1
Short name:
SH2 domain protein C1
Gene namesi
Name:SHC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272201 – 473SHC-transforming protein 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei239PhosphotyrosineBy similarity1
Modified residuei240PhosphotyrosineBy similarity1
Modified residuei317PhosphotyrosineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 and FLT4 signaling and by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1. Tyrosine phosphorylated by activated PTK2B/PYK2. Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0IIE2.
PRIDEiQ0IIE2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019838.
ExpressionAtlasiQ0IIE2. baseline and differential.

Interactioni

Subunit structurei

Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026432.

Structurei

3D structure databases

ProteinModelPortaliQ0IIE2.
SMRiQ0IIE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 229PIDPROSITE-ProRule annotationAdd BLAST184
Domaini378 – 469SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 377CH1Add BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 9Poly-Gly4
Compositional biasi301 – 364Pro-richAdd BLAST64

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ0IIE2.
KOiK06279.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IIE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110 120 130 140 150
PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI
160 170 180 190 200
SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL
210 220 230 240 250
RFKQYLRNPP RLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
260 270 280 290 300
GGVVDMRLRE GALPGAARPT PPSAQTPSHL GATLPVGQPA GGDPEARRQM
310 320 330 340 350
PPPPPSSGRE LFDDPSYVNV QNLDKARQAG AGAGPPNPTI NGSAPRDLFD
360 370 380 390 400
MKPFEDALRM PPPPQSTAMA EQLRGEPWFH GKLSRREAEA LLQVNGDFLV
410 420 430 440 450
RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE SVSHLISYHM
460 470
DNHLPIISAG SELCLQQPVE RKL
Length:473
Mass (Da):51,631
Last modified:October 3, 2006 - v1
Checksum:iD2B0277087268CDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3NK → HN in AAZ38953 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122688 mRNA. Translation: AAI22689.1.
DQ125497 mRNA. Translation: AAZ38953.1.
RefSeqiNP_001068773.1. NM_001075305.2.
NP_001157533.1. NM_001164061.1.
UniGeneiBt.4279.

Genome annotation databases

EnsembliENSBTAT00000040264; ENSBTAP00000040041; ENSBTAG00000019838.
GeneIDi507196.
KEGGibta:507196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122688 mRNA. Translation: AAI22689.1.
DQ125497 mRNA. Translation: AAZ38953.1.
RefSeqiNP_001068773.1. NM_001075305.2.
NP_001157533.1. NM_001164061.1.
UniGeneiBt.4279.

3D structure databases

ProteinModelPortaliQ0IIE2.
SMRiQ0IIE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026432.

Proteomic databases

PaxDbiQ0IIE2.
PRIDEiQ0IIE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000040264; ENSBTAP00000040041; ENSBTAG00000019838.
GeneIDi507196.
KEGGibta:507196.

Organism-specific databases

CTDi6464.

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiQ0IIE2.
KOiK06279.

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-1250196. SHC1 events in ERBB2 signaling.
R-BTA-1250347. SHC1 events in ERBB4 signaling.
R-BTA-167044. Signalling to RAS.
R-BTA-180336. SHC1 events in EGFR signaling.
R-BTA-210993. Tie2 Signaling.
R-BTA-2424491. DAP12 signaling.
R-BTA-2428933. SHC-related events triggered by IGF1R.
R-BTA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-2871809. FCERI mediated Ca+2 mobilization.
R-BTA-354192. Integrin alphaIIb beta3 signaling.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-451927. Interleukin-2 signaling.
R-BTA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-BTA-5654688. SHC-mediated cascade:FGFR1.
R-BTA-5654699. SHC-mediated cascade:FGFR2.
R-BTA-5654704. SHC-mediated cascade:FGFR3.
R-BTA-5654719. SHC-mediated cascade:FGFR4.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-74749. Signal attenuation.
R-BTA-74751. Insulin receptor signalling cascade.
R-BTA-8851805. MET activates RAS signaling.
R-BTA-8853659. RET signaling.
R-BTA-912526. Interleukin receptor SHC signaling.
R-BTA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Gene expression databases

BgeeiENSBTAG00000019838.
ExpressionAtlasiQ0IIE2. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029586. Shc1/ShcA.
[Graphical view]
PANTHERiPTHR10337:SF2. PTHR10337:SF2. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHC1_BOVIN
AccessioniPrimary (citable) accession number: Q0IIE2
Secondary accession number(s): Q45KX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.