ID   GLPK_BOVIN              Reviewed;         559 AA.
AC   Q0IID9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Glycerol kinase;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase;
DE   AltName: Full=Glycerokinase;
DE            Short=GK;
GN   Name=GK;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC       metabolism (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC       phosphate.
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC       kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral
CC       membrane protein; Cytoplasmic side (By similarity). Cytoplasm (By
CC       similarity). Note=Bound to the mitochondrial surface or
CC       cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR   EMBL; BC122692; AAI22693.1; -; mRNA.
DR   IPI; IPI00707036; -.
DR   RefSeq; NP_001068704.1; -.
DR   UniGene; Bt.18414; -.
DR   Ensembl; ENSBTAG00000008124; Bos taurus.
DR   GeneID; 505987; -.
DR   KEGG; bta:505987; -.
DR   HOVERGEN; Q0IID9; -.
DR   OMA; Q0IID9; KPVMSDH.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR005999; Glycerol_kin.
DR   PANTHER; PTHR10196; FGGY_kin; 1.
DR   PANTHER; PTHR10196:SF9; Glycerol_kin; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Glycerol metabolism; Kinase; Membrane;
KW   Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    559       Glycerol kinase.
FT                                /FTId=PRO_0000343676.
FT   NP_BIND     433    437       ATP (By similarity).
FT   BINDING      20     20       Substrate (By similarity).
FT   BINDING      24     24       ATP (By similarity).
FT   BINDING      94     94       Substrate (By similarity).
FT   BINDING     148    148       Substrate (By similarity).
FT   BINDING     265    265       Substrate (By similarity).
FT   BINDING     287    287       ATP (By similarity).
FT   BINDING     332    332       ATP; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   559 AA;  61261 MW;  CBD4FC2D97A0A682 CRC64;
     MASAKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI
     LQSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKLTGEPLYN AVVWLDLRTQ
     STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE DRALFGTIDS
     WLIWSLTGGA SGGVHCTDVT NASRTMLFNI HSLEWDKELC EFFEIPMKIL PNVRSSSEIY
     GLMKISHSPK AGALEGVPIS GCLGDQSAAL VGQMCFQDGQ AKNTYGTGCF LLCNTGRKCV
     FSEHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKSSEE IEKLAKEVGT
     SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF AALEAVCFQT REILDAMNRD
     CGIPLSHLQV DGGMTNNKIL MQLQADILYI PVVKPSMPET TALGAAMAAG AAEGVGVWSL
     EPEDLSAVTM ERFEPQINAE ESEIRYSTWK KAVMKSMGWV TTQSSESGDP SIFCSLPLGF
     FIVSSVVMLI GARYLSGMP
//