Reviewed,
UniProtKB/Swiss-Prot Q0IID9 (GLPK_BOVIN)
Last modified
June 16, 2009.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glycerol kinase EC=2.7.1.30 Alternative name(s): ATP:glycerol 3-phosphotransferase Glycerokinase Short name=GK | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 559 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Key enzyme in the regulation of glycerol uptake and metabolism By similarity. |
| Catalytic activity | ATP + glycerol = ADP + sn-glycerol 3-phosphate. |
| Pathway | |
| Subcellular location | Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Bound to the mitochondrial surface or cytoplasmic By similarity. |
| Sequence similarities | Belongs to the FGGY kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycerol metabolism |
| Cellular component | Cytoplasm Membrane Mitochondrion Mitochondrion outer membrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 559 | 559 | Glycerol kinase | PRO_0000343676 | |||||
Regions | |||||||||
| Nucleotide binding | 433 – 437 | 5 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 20 | 1 | Substrate By similarity | ||||||
| Binding site | 24 | 1 | ATP By similarity | ||||||
| Binding site | 94 | 1 | Substrate By similarity | ||||||
| Binding site | 148 | 1 | Substrate By similarity | ||||||
| Binding site | 265 | 1 | Substrate By similarity | ||||||
| Binding site | 287 | 1 | ATP By similarity | ||||||
| Binding site | 332 | 1 | ATP; via carbonyl oxygen By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hippocampus. |
Cross-references
Sequence databases | |
|---|---|
| BC122692 mRNA. Translation: AAI22693.1. | |
| IPI | IPI00707036. |
| RefSeq | NP_001068704.1. |
| UniGene | Bt.18414 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000008124. Bos taurus. [Contig view] |
| GeneID | 505987. |
| KEGG | bta:505987. |
Phylogenomic databases | |
| HOVERGEN | Q0IID9. |
| OMA | Q0IID9. KPVMSDH. |
Family and domain databases | |
| InterPro | IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view] |
| PANTHER | PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit. |
| Pfam | PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01311. glycerol_kin. 1 hit. |
| PROSITE | PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GLPK_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q0IID9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


