Reviewed, UniProtKB/Swiss-Prot Q0IID7 (DUS10_BOVIN)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 10
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

DUSP10

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	Dual specificity protein phosphatase 10		PRO_0000283703
Regions
	Domain	168 – 285	118	Rhodanese
	Domain	384 – 453	70	Tyrosine-protein phosphatase
Sites
	Active site	408	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	4	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0IID7-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 11392A5321B94BBF	FASTA	482	52,389
	10 20 30 40 50 60 MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSAAPGST SHPPVIATTV VSLKAANLTY 70 80 90 100 110 120 MPSSSGSARS LNCGCSSASC CTVATYDKDN QAPTQAIAAG TATTAIGSST TCPASQMVNN 130 140 150 160 170 180 SENAGSLSPS GGVGSPMAGT PKQLASIKII YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF 190 200 210 220 230 240 MEYNKSHIQG AVHINCADKI SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT 250 260 270 280 290 300 NEPSRVVPSQ PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA 310 320 330 340 350 360 SAASSMLPQS IPSTPDIENA ELTPILPFLF LGNEQDAQDL ETMQRLNIGY VINVTTHLPL 370 380 390 400 410 420 YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC GKGLLIHCQA GVSRSATIVI 430 440 450 460 470 480 AYLMKHTRMT MTDAYKFVKG KRPIISPNLN FMGQLLEFEE DLNNGVTPRI LTPKLMGVET VV

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC122694 mRNA. Translation: AAI22695.1.
IPI	IPI00696253.
RefSeq	NP_001029897.2.
UniGene	Bt.2070
3D structure databases
SMR	Q0IID7. Positions 321-467.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000001729. Bos taurus. [Contig view]
GeneID	541175.
KEGG	bta:541175.
Phylogenomic databases
HOVERGEN	Q0IID7.
OMA	Q0IID7. NEHDAQD.
Enzyme and pathway databases
BRENDA	3.1.3.16. 251. 3.1.3.48. 251.
Family and domain databases
InterPro	IPR008343. MAPK_phosph. IPR001763. Rhodanese-like. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view]
Gene3D	G3DSA:3.40.250.10. Rhodanese-like. 1 hit.
Pfam	PF00782. DSPc. 1 hit. PF00581. Rhodanese. 1 hit. [Graphical view]
PRINTS	PR01764. MAPKPHPHTASE.
SMART	SM00195. DSPc. 1 hit. SM00450. RHOD. 1 hit. [Graphical view]
PROSITE	PS50206. RHODANESE_3. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS10_BOVIN

Accession

Primary (citable) accession number: Q0IID7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)