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Protein

Dual specificity protein phosphatase 10

Gene

DUSP10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei408Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-BTA-112409 RAF-independent MAPK1/3 activation
R-BTA-5675221 Negative regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 10 (EC:3.1.3.16By similarity, EC:3.1.3.48By similarity)
Gene namesi
Name:DUSP10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:28249 DUSP10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837031 – 482Dual specificity protein phosphatase 10Add BLAST482

Proteomic databases

PaxDbiQ0IID7
PRIDEiQ0IID7

Expressioni

Gene expression databases

BgeeiENSBTAG00000001729
ExpressionAtlasiQ0IID7 baseline and differential

Interactioni

Subunit structurei

Monomer. Interacts with MAPK14.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002265

Structurei

3D structure databases

ProteinModelPortaliQ0IID7
SMRiQ0IID7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 285RhodanesePROSITE-ProRule annotationAdd BLAST118
Domaini384 – 453Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 215Interaction with MAP kinasesBy similarityAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000069871
HOVERGENiHBG102158
InParanoidiQ0IID7
KOiK20216
OMAiMTKCSKS
OrthoDBiEOG091G0V6S
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q0IID7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSAAPGST SHPPVIATTV
60 70 80 90 100
VSLKAANLTY MPSSSGSARS LNCGCSSASC CTVATYDKDN QAPTQAIAAG
110 120 130 140 150
TATTAIGSST TCPASQMVNN SENAGSLSPS GGVGSPMAGT PKQLASIKII
160 170 180 190 200
YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF MEYNKSHIQG AVHINCADKI
210 220 230 240 250
SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT NEPSRVVPSQ
260 270 280 290 300
PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA
310 320 330 340 350
SAASSMLPQS IPSTPDIENA ELTPILPFLF LGNEQDAQDL ETMQRLNIGY
360 370 380 390 400
VINVTTHLPL YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC
410 420 430 440 450
GKGLLIHCQA GVSRSATIVI AYLMKHTRMT MTDAYKFVKG KRPIISPNLN
460 470 480
FMGQLLEFEE DLNNGVTPRI LTPKLMGVET VV
Length:482
Mass (Da):52,389
Last modified:October 3, 2006 - v1
Checksum:i11392A5321B94BBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122694 mRNA Translation: AAI22695.1
RefSeqiNP_001029897.2, NM_001034725.2
XP_005216894.1, XM_005216837.3
UniGeneiBt.2070

Genome annotation databases

EnsembliENSBTAT00000002265; ENSBTAP00000002265; ENSBTAG00000001729
GeneIDi541175
KEGGibta:541175

Similar proteinsi

Entry informationi

Entry nameiDUS10_BOVIN
AccessioniPrimary (citable) accession number: Q0IID7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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