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Q0IID7

- DUS10_BOVIN

UniProt

Q0IID7 - DUS10_BOVIN

Protein

Dual specificity protein phosphatase 10

Gene

DUSP10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei408 – 4081Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase phosphatase activity Source: UniProtKB
    2. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: UniProtKB
    2. negative regulation of JNK cascade Source: RefGenome
    3. negative regulation of JUN kinase activity Source: RefGenome
    4. negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
    5. protein dephosphorylation Source: UniProtKB
    6. regulation of adaptive immune response Source: Ensembl
    7. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 10 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482Dual specificity protein phosphatase 10PRO_0000283703Add
    BLAST

    Proteomic databases

    PRIDEiQ0IID7.

    Interactioni

    Subunit structurei

    Monomer. Interacts with MAPK14 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000002265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IID7.
    SMRiQ0IID7. Positions 148-287, 315-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 285118RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 45370Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 21517Interaction with MAP kinasesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117567.
    HOGENOMiHOG000069871.
    HOVERGENiHBG102158.
    InParanoidiQ0IID7.
    KOiK04459.
    OMAiTCPANQM.
    OrthoDBiEOG75QR5B.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0IID7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSAAPGST SHPPVIATTV    50
    VSLKAANLTY MPSSSGSARS LNCGCSSASC CTVATYDKDN QAPTQAIAAG 100
    TATTAIGSST TCPASQMVNN SENAGSLSPS GGVGSPMAGT PKQLASIKII 150
    YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF MEYNKSHIQG AVHINCADKI 200
    SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT NEPSRVVPSQ 250
    PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA 300
    SAASSMLPQS IPSTPDIENA ELTPILPFLF LGNEQDAQDL ETMQRLNIGY 350
    VINVTTHLPL YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC 400
    GKGLLIHCQA GVSRSATIVI AYLMKHTRMT MTDAYKFVKG KRPIISPNLN 450
    FMGQLLEFEE DLNNGVTPRI LTPKLMGVET VV 482
    Length:482
    Mass (Da):52,389
    Last modified:October 3, 2006 - v1
    Checksum:i11392A5321B94BBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122694 mRNA. Translation: AAI22695.1.
    RefSeqiNP_001029897.2. NM_001034725.2.
    XP_005216894.1. XM_005216837.1.
    UniGeneiBt.2070.

    Genome annotation databases

    EnsembliENSBTAT00000002265; ENSBTAP00000002265; ENSBTAG00000001729.
    GeneIDi541175.
    KEGGibta:541175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122694 mRNA. Translation: AAI22695.1 .
    RefSeqi NP_001029897.2. NM_001034725.2.
    XP_005216894.1. XM_005216837.1.
    UniGenei Bt.2070.

    3D structure databases

    ProteinModelPortali Q0IID7.
    SMRi Q0IID7. Positions 148-287, 315-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000002265.

    Proteomic databases

    PRIDEi Q0IID7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002265 ; ENSBTAP00000002265 ; ENSBTAG00000001729 .
    GeneIDi 541175.
    KEGGi bta:541175.

    Organism-specific databases

    CTDi 11221.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117567.
    HOGENOMi HOG000069871.
    HOVERGENi HBG102158.
    InParanoidi Q0IID7.
    KOi K04459.
    OMAi TCPANQM.
    OrthoDBi EOG75QR5B.
    TreeFami TF105122.

    Miscellaneous databases

    NextBioi 20879052.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal muscle.

    Entry informationi

    Entry nameiDUS10_BOVIN
    AccessioniPrimary (citable) accession number: Q0IID7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3