Reviewed,
UniProtKB/Swiss-Prot Q0IID7 (DUS10_BOVIN)
Last modified
June 16, 2009.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 10 EC=3.1.3.48 EC=3.1.3.16 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 482 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Hydrolase Protein phosphatase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 482 | 482 | Dual specificity protein phosphatase 10 | PRO_0000283703 | |||||
Regions | |||||||||
| Domain | 168 – 285 | 118 | Rhodanese | ||||||
| Domain | 384 – 453 | 70 | Tyrosine-protein phosphatase | ||||||
Sites | |||||||||
| Active site | 408 | 1 | Phosphocysteine intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 4 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle. |
Cross-references
Sequence databases | |
|---|---|
| BC122694 mRNA. Translation: AAI22695.1. | |
| IPI | IPI00696253. |
| RefSeq | NP_001029897.2. |
| UniGene | Bt.2070 |
3D structure databases | |
| SMR | Q0IID7. Positions 321-467. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000001729. Bos taurus. [Contig view] |
| GeneID | 541175. |
| KEGG | bta:541175. |
Phylogenomic databases | |
| HOVERGEN | Q0IID7. |
| OMA | Q0IID7. NEHDAQD. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 251. 3.1.3.48. 251. |
Family and domain databases | |
| InterPro | IPR008343. MAPK_phosph. IPR001763. Rhodanese-like. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view] |
| Gene3D | G3DSA:3.40.250.10. Rhodanese-like. 1 hit. |
| Pfam | PF00782. DSPc. 1 hit. PF00581. Rhodanese. 1 hit. [Graphical view] |
| PRINTS | PR01764. MAPKPHPHTASE. |
| SMART | SM00195. DSPc. 1 hit. SM00450. RHOD. 1 hit. [Graphical view] |
| PROSITE | PS50206. RHODANESE_3. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DUS10_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q0IID7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


