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Q0IID7 (DUS10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 10

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:DUSP10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Monomer. Interacts with MAPK14 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinactivation of MAPK activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of JNK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of JUN kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of respiratory burst involved in inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of stress-activated MAPK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein dephosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of adaptive immune response

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionMAP kinase phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

MAP kinase tyrosine/serine/threonine phosphatase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482Dual specificity protein phosphatase 10
PRO_0000283703

Regions

Domain168 – 285118Rhodanese
Domain384 – 45370Tyrosine-protein phosphatase
Region199 – 21517Interaction with MAP kinases By similarity

Sites

Active site4081Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IID7 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 11392A5321B94BBF

FASTA48252,389
        10         20         30         40         50         60 
MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSAAPGST SHPPVIATTV VSLKAANLTY 

        70         80         90        100        110        120 
MPSSSGSARS LNCGCSSASC CTVATYDKDN QAPTQAIAAG TATTAIGSST TCPASQMVNN 

       130        140        150        160        170        180 
SENAGSLSPS GGVGSPMAGT PKQLASIKII YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF 

       190        200        210        220        230        240 
MEYNKSHIQG AVHINCADKI SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT 

       250        260        270        280        290        300 
NEPSRVVPSQ PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA 

       310        320        330        340        350        360 
SAASSMLPQS IPSTPDIENA ELTPILPFLF LGNEQDAQDL ETMQRLNIGY VINVTTHLPL 

       370        380        390        400        410        420 
YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC GKGLLIHCQA GVSRSATIVI 

       430        440        450        460        470        480 
AYLMKHTRMT MTDAYKFVKG KRPIISPNLN FMGQLLEFEE DLNNGVTPRI LTPKLMGVET 


VV 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122694 mRNA. Translation: AAI22695.1.
RefSeqNP_001029897.2. NM_001034725.2.
XP_005216894.1. XM_005216837.1.
UniGeneBt.2070.

3D structure databases

ProteinModelPortalQ0IID7.
SMRQ0IID7. Positions 148-287, 315-482.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000002265.

Proteomic databases

PRIDEQ0IID7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002265; ENSBTAP00000002265; ENSBTAG00000001729.
GeneID541175.
KEGGbta:541175.

Organism-specific databases

CTD11221.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00750000117567.
HOGENOMHOG000069871.
HOVERGENHBG102158.
InParanoidQ0IID7.
KOK04459.
OMATCPANQM.
OrthoDBEOG75QR5B.
TreeFamTF105122.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20879052.

Entry information

Entry nameDUS10_BOVIN
AccessionPrimary (citable) accession number: Q0IID7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families