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Protein

Synaptosomal-associated protein 29

Gene

SNAP29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29By similarity
Short name:
SNAP-29By similarity
Alternative name(s):
Soluble 29 kDa NSF attachment proteinBy similarity
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:SNAP29By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:35052 SNAP29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828741 – 258Synaptosomal-associated protein 29Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei130PhosphothreonineBy similarity1
Modified residuei137PhosphothreonineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0II86
PeptideAtlasiQ0II86
PRIDEiQ0II86

Expressioni

Gene expression databases

BgeeiENSBTAG00000020760

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome. Interacts with multiple syntaxins including STX6. Interacts with EIPR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027666

Structurei

3D structure databases

ProteinModelPortaliQ0II86
SMRiQ0II86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 258t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 107Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00510000048053
HOGENOMiHOG000046806
HOVERGENiHBG057045
InParanoidiQ0II86
KOiK08509
OMAiQEAQYQA
OrthoDBiEOG091G0GKH
TreeFamiTF320226

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
SMARTiView protein in SMART
SM00397 t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0II86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYPRSYNP FDEDAEDEDA RPAPWSDSRD LADGPGAPAD RQQALRQEVL
60 70 80 90 100
RRAEATAAST GRSLSLMYES ERIGVVSAEE LVRQRGALER TEKMVDKMEQ
110 120 130 140 150
DLKTSQKHIN SIKSVFGGLV NYFRSKPAET PSAQNGTLTP QPSGRLKDAI
160 170 180 190 200
NSSKEQEAQY QASHPNLRKL QDSDSIPGGA GSAVSSEAYP RNPHLRACHQ
210 220 230 240 250
RIDSNLDELS VGLGRLKDIA LGIQTEIDEQ DDILDRLTSK VDKLDVSITS

TERKVRQL
Length:258
Mass (Da):28,490
Last modified:October 3, 2006 - v1
Checksum:i6F450322040BE683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122755 mRNA Translation: AAI22756.1
RefSeqiNP_001069427.1, NM_001075959.1
UniGeneiBt.76130

Genome annotation databases

EnsembliENSBTAT00000027666; ENSBTAP00000027666; ENSBTAG00000020760
GeneIDi532261
KEGGibta:532261

Similar proteinsi

Entry informationi

Entry nameiSNP29_BOVIN
AccessioniPrimary (citable) accession number: Q0II86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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