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Protein

Synaptosomal-associated protein 29

Gene

SNAP29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29By similarity
Short name:
SNAP-29By similarity
Alternative name(s):
Soluble 29 kDa NSF attachment proteinBy similarity
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:SNAP29By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasm By similarity
  • Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity
  • Cytoplasmic vesicleautophagosome membrane By similarity; Peripheral membrane protein By similarity
  • Cell projectioncilium membrane By similarity; Peripheral membrane protein By similarity

  • Note: Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Synaptosomal-associated protein 29PRO_0000282874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei114 – 1141PhosphoserineBy similarity
Modified residuei130 – 1301PhosphothreonineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei185 – 1851PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei210 – 2101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0II86.
PeptideAtlasiQ0II86.
PRIDEiQ0II86.

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (By similarity). Interacts with multiple syntaxins including STX6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027666.

Structurei

3D structure databases

ProteinModelPortaliQ0II86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 25863t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 10732Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00510000048053.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiQ0II86.
KOiK08509.
OMAiQEAQYQA.
OrthoDBiEOG7FNC8G.
TreeFamiTF320226.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0II86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYPRSYNP FDEDAEDEDA RPAPWSDSRD LADGPGAPAD RQQALRQEVL
60 70 80 90 100
RRAEATAAST GRSLSLMYES ERIGVVSAEE LVRQRGALER TEKMVDKMEQ
110 120 130 140 150
DLKTSQKHIN SIKSVFGGLV NYFRSKPAET PSAQNGTLTP QPSGRLKDAI
160 170 180 190 200
NSSKEQEAQY QASHPNLRKL QDSDSIPGGA GSAVSSEAYP RNPHLRACHQ
210 220 230 240 250
RIDSNLDELS VGLGRLKDIA LGIQTEIDEQ DDILDRLTSK VDKLDVSITS

TERKVRQL
Length:258
Mass (Da):28,490
Last modified:October 3, 2006 - v1
Checksum:i6F450322040BE683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122755 mRNA. Translation: AAI22756.1.
RefSeqiNP_001069427.1. NM_001075959.1.
UniGeneiBt.76130.

Genome annotation databases

EnsembliENSBTAT00000027666; ENSBTAP00000027666; ENSBTAG00000020760.
GeneIDi532261.
KEGGibta:532261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122755 mRNA. Translation: AAI22756.1.
RefSeqiNP_001069427.1. NM_001075959.1.
UniGeneiBt.76130.

3D structure databases

ProteinModelPortaliQ0II86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027666.

Proteomic databases

PaxDbiQ0II86.
PeptideAtlasiQ0II86.
PRIDEiQ0II86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027666; ENSBTAP00000027666; ENSBTAG00000020760.
GeneIDi532261.
KEGGibta:532261.

Organism-specific databases

CTDi9342.

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00510000048053.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiQ0II86.
KOiK08509.
OMAiQEAQYQA.
OrthoDBiEOG7FNC8G.
TreeFamiTF320226.

Enzyme and pathway databases

ReactomeiR-BTA-6811438. Intra-Golgi traffic.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiSNP29_BOVIN
AccessioniPrimary (citable) accession number: Q0II86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.