ID   ACMSD_BOVIN             Reviewed;         336 AA.
AC   Q0II68;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   10-FEB-2009, entry version 18.
DE   RecName: Full=2-amino-3-carboxymuconate-6-semialdehyde decarboxylase;
DE            EC=4.1.1.45;
GN   Name=ACMSD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-
CC       semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).
CC       ACMS can be converted non-enzymatically to quinolate, a potent
CC       endogenous excitotoxin of neuronal cells which is implicated in
CC       the pathogenesis of various neurodegenerative disorders. In the
CC       presence of ACMSD, ACMS is converted to AMS, a benign catabolite
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
CC       = 2-aminomuconate semialdehyde + CO(2).
CC   -!- PATHWAY: Secondary metabolite metabolism; quinolate metabolism.
CC   -!- SIMILARITY: Belongs to the ACMSD family.
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DR   EMBL; BC122781; AAI22782.1; -; mRNA.
DR   IPI; IPI00696862; -.
DR   RefSeq; NP_001069162.1; -.
DR   UniGene; Bt.21101; -.
DR   Ensembl; ENSBTAG00000008039; Bos taurus.
DR   GeneID; 515030; -.
DR   KEGG; bta:515030; -.
DR   HOVERGEN; Q0II68; -.
DR   BRENDA; 4.1.1.45; 251.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0001760; F:aminocarboxymuconate-semialdehyde decarboxy...; ISS:UniProtKB.
DR   GO; GO:0046874; P:quinolinate metabolic process; ISS:UniProtKB.
DR   InterPro; IPR006992; Amidohydro_2.
DR   Pfam; PF04909; Amidohydro_2; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Phosphoprotein.
FT   CHAIN         1    336       2-amino-3-carboxymuconate-6-semialdehyde
FT                                decarboxylase.
FT                                /FTId=PRO_0000270786.
FT   MOD_RES       7      7       Phosphothreonine (By similarity).
FT   MOD_RES     116    116       Phosphothreonine (By similarity).
SQ   SEQUENCE   336 AA;  37923 MW;  4C859894716055C2 CRC64;
     MKIDIHTHIL PREWPDLKKR FGYGGWVQLQ HNGKGEAKML KDGKVFRVVQ ENCWDPEARL
     REMDQTGVTV QALSTVPVMF SYWAKPQDTL DLCQLLNNDL AATIASHPRR FVGLGTLPMQ
     APELAVKEME RCVRKLGFPG VQIGSHINEW DLNARELFPV YAEAERLNCS LFVHPWDMQM
     DGRMAKYWFP WLIGMPAETT AAICSMIMGG VFEKFPKLKV CFAHGGGSFP FTVGRISHGF
     SMRPDLCAQD NPTNPKKYLG SFYTDSLVHD PLALKLLTDV IGKDKVILGT DYPFPLGELE
     PGKLIESMGE FDAETKDKLK AGNALEFLGL ERKQFE
//