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Protein

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Gene

ACMSD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity).By similarity

Catalytic activityi

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.

Pathwayi: quinolate metabolism

This protein is involved in the pathway quinolate metabolism, which is part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the pathway quinolate metabolism and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61ZincBy similarity
Metal bindingi8 – 81ZincBy similarity
Binding sitei47 – 471SubstrateBy similarity
Metal bindingi174 – 1741ZincBy similarity
Metal bindingi291 – 2911ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00270.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC:4.1.1.45)
Alternative name(s):
Picolinate carboxylase
Gene namesi
Name:ACMSD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3363362-amino-3-carboxymuconate-6-semialdehyde decarboxylasePRO_0000270786Add
BLAST

Proteomic databases

PaxDbiQ0II68.
PRIDEiQ0II68.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010575.

Structurei

3D structure databases

ProteinModelPortaliQ0II68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACMSD family.Curated

Phylogenomic databases

eggNOGiKOG4245. Eukaryota.
COG2159. LUCA.
GeneTreeiENSGT00490000043417.
HOGENOMiHOG000254105.
HOVERGENiHBG050450.
InParanoidiQ0II68.
KOiK03392.
OMAiHPWDMQT.
OrthoDBiEOG7WDN2Q.
TreeFamiTF313232.

Family and domain databases

InterProiIPR032465. ACMSD.
IPR006680. Amidohydro-rel.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR21240:SF3. PTHR21240:SF3. 1 hit.
PfamiPF04909. Amidohydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0II68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIDIHTHIL PREWPDLKKR FGYGGWVQLQ HNGKGEAKML KDGKVFRVVQ
60 70 80 90 100
ENCWDPEARL REMDQTGVTV QALSTVPVMF SYWAKPQDTL DLCQLLNNDL
110 120 130 140 150
AATIASHPRR FVGLGTLPMQ APELAVKEME RCVRKLGFPG VQIGSHINEW
160 170 180 190 200
DLNARELFPV YAEAERLNCS LFVHPWDMQM DGRMAKYWFP WLIGMPAETT
210 220 230 240 250
AAICSMIMGG VFEKFPKLKV CFAHGGGSFP FTVGRISHGF SMRPDLCAQD
260 270 280 290 300
NPTNPKKYLG SFYTDSLVHD PLALKLLTDV IGKDKVILGT DYPFPLGELE
310 320 330
PGKLIESMGE FDAETKDKLK AGNALEFLGL ERKQFE
Length:336
Mass (Da):37,923
Last modified:October 3, 2006 - v1
Checksum:i4C859894716055C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122781 mRNA. Translation: AAI22782.1.
RefSeqiNP_001069162.1. NM_001075694.1.
UniGeneiBt.21101.

Genome annotation databases

EnsembliENSBTAT00000010575; ENSBTAP00000010575; ENSBTAG00000008039.
GeneIDi515030.
KEGGibta:515030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122781 mRNA. Translation: AAI22782.1.
RefSeqiNP_001069162.1. NM_001075694.1.
UniGeneiBt.21101.

3D structure databases

ProteinModelPortaliQ0II68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010575.

Proteomic databases

PaxDbiQ0II68.
PRIDEiQ0II68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010575; ENSBTAP00000010575; ENSBTAG00000008039.
GeneIDi515030.
KEGGibta:515030.

Organism-specific databases

CTDi130013.

Phylogenomic databases

eggNOGiKOG4245. Eukaryota.
COG2159. LUCA.
GeneTreeiENSGT00490000043417.
HOGENOMiHOG000254105.
HOVERGENiHBG050450.
InParanoidiQ0II68.
KOiK03392.
OMAiHPWDMQT.
OrthoDBiEOG7WDN2Q.
TreeFamiTF313232.

Enzyme and pathway databases

UniPathwayiUPA00270.

Family and domain databases

InterProiIPR032465. ACMSD.
IPR006680. Amidohydro-rel.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR21240:SF3. PTHR21240:SF3. 1 hit.
PfamiPF04909. Amidohydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiACMSD_BOVIN
AccessioniPrimary (citable) accession number: Q0II68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.