Reviewed, UniProtKB/Swiss-Prot Q0II68 (ACMSD_BOVIN)

Names and origin

Protein names

Recommended name:
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    EC=4.1.1.45

Gene names

Name:

ACMSD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate, a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite By similarity.
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	quinolinate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000270786
Amino acid modifications
	Modified residue	7	1	Phosphothreonine By similarity
	Modified residue	116	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0II68-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 4C859894716055C2	FASTA	336	37,923
	10 20 30 40 50 60 MKIDIHTHIL PREWPDLKKR FGYGGWVQLQ HNGKGEAKML KDGKVFRVVQ ENCWDPEARL 70 80 90 100 110 120 REMDQTGVTV QALSTVPVMF SYWAKPQDTL DLCQLLNNDL AATIASHPRR FVGLGTLPMQ 130 140 150 160 170 180 APELAVKEME RCVRKLGFPG VQIGSHINEW DLNARELFPV YAEAERLNCS LFVHPWDMQM 190 200 210 220 230 240 DGRMAKYWFP WLIGMPAETT AAICSMIMGG VFEKFPKLKV CFAHGGGSFP FTVGRISHGF 250 260 270 280 290 300 SMRPDLCAQD NPTNPKKYLG SFYTDSLVHD PLALKLLTDV IGKDKVILGT DYPFPLGELE 310 320 330 PGKLIESMGE FDAETKDKLK AGNALEFLGL ERKQFE

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC122781 mRNA. Translation: AAI22782.1.
IPI	IPI00696862.
RefSeq	NP_001069162.1.
UniGene	Bt.21101
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000008039. Bos taurus. [Contig view]
GeneID	515030.
KEGG	bta:515030.
Phylogenomic databases
HOVERGEN	Q0II68.
Enzyme and pathway databases
BRENDA	4.1.1.45. 251.
Family and domain databases
InterPro	IPR006992. Amidohydro_2. [Graphical view]
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACMSD_BOVIN

Accession

Primary (citable) accession number: Q0II68

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 3, 2006
Last modified:	February 10, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)