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Protein

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Gene

ACMSD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity).By similarity

Catalytic activityi

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.

Pathwayi: quinolate metabolism

This protein is involved in the pathway quinolate metabolism, which is part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the pathway quinolate metabolism and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6ZincBy similarity1
Metal bindingi8ZincBy similarity1
Binding sitei47SubstrateBy similarity1
Metal bindingi174ZincBy similarity1
Metal bindingi291ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00270

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC:4.1.1.45)
Alternative name(s):
Picolinate carboxylase
Gene namesi
Name:ACMSD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:25544 ACMSD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002707861 – 3362-amino-3-carboxymuconate-6-semialdehyde decarboxylaseAdd BLAST336

Proteomic databases

PaxDbiQ0II68
PRIDEiQ0II68

Expressioni

Gene expression databases

BgeeiENSBTAG00000008039

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010575

Structurei

3D structure databases

ProteinModelPortaliQ0II68
SMRiQ0II68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4245 Eukaryota
COG2159 LUCA
GeneTreeiENSGT00490000043417
HOGENOMiHOG000254105
HOVERGENiHBG050450
InParanoidiQ0II68
KOiK03392
OMAiNEWDLNA
OrthoDBiEOG091G0BZB
TreeFamiTF313232

Family and domain databases

InterProiView protein in InterPro
IPR032465 ACMSD
IPR006680 Amidohydro-rel
IPR032466 Metal_Hydrolase
PANTHERiPTHR21240 PTHR21240, 1 hit
PfamiView protein in Pfam
PF04909 Amidohydro_2, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequencei

Sequence statusi: Complete.

Q0II68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIDIHTHIL PREWPDLKKR FGYGGWVQLQ HNGKGEAKML KDGKVFRVVQ
60 70 80 90 100
ENCWDPEARL REMDQTGVTV QALSTVPVMF SYWAKPQDTL DLCQLLNNDL
110 120 130 140 150
AATIASHPRR FVGLGTLPMQ APELAVKEME RCVRKLGFPG VQIGSHINEW
160 170 180 190 200
DLNARELFPV YAEAERLNCS LFVHPWDMQM DGRMAKYWFP WLIGMPAETT
210 220 230 240 250
AAICSMIMGG VFEKFPKLKV CFAHGGGSFP FTVGRISHGF SMRPDLCAQD
260 270 280 290 300
NPTNPKKYLG SFYTDSLVHD PLALKLLTDV IGKDKVILGT DYPFPLGELE
310 320 330
PGKLIESMGE FDAETKDKLK AGNALEFLGL ERKQFE
Length:336
Mass (Da):37,923
Last modified:October 3, 2006 - v1
Checksum:i4C859894716055C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122781 mRNA Translation: AAI22782.1
RefSeqiNP_001069162.1, NM_001075694.1
UniGeneiBt.21101

Genome annotation databases

EnsembliENSBTAT00000010575; ENSBTAP00000010575; ENSBTAG00000008039
GeneIDi515030
KEGGibta:515030

Similar proteinsi

Entry informationi

Entry nameiACMSD_BOVIN
AccessioniPrimary (citable) accession number: Q0II68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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