Q0II59 (PDXK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxal kinase
EC=2.7.1.35

Alternative name(s):
Pyridoxine kinase

Gene names

Name:

PDXK

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for synthesis of pyridoxal-5-phosphate from vitamin B6 By similarity.
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.
Cofactor	Divalent cations. Zinc is more efficient than magnesium By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyridoxal 5'-phosphate salvage Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pyridoxal kinase		PRO_0000268830
Regions
	Nucleotide binding	186 – 187	2	ATP By similarity
	Nucleotide binding	223 – 234	12	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	47	1	Substrate By similarity
	Binding site	127	1	Substrate By similarity
	Binding site	235	1	Substrate By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
	Modified residue	59	1	Phosphoserine By similarity
	Modified residue	84	1	Phosphotyrosine By similarity
	Modified residue	196	1	Phosphoserine By similarity
	Modified residue	204	1	Phosphoserine By similarity
	Modified residue	213	1	Phosphoserine By similarity
	Modified residue	259	1	Phosphothreonine By similarity
	Modified residue	285	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0II59 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 7FDD3E0153DFB7CC	FASTA	312	34,817
	10 20 30 40 50 60 MEEECRVLSI QSHVVRGYVG NRAATFPLQV LGFEVDAVNS VQFSNHTGYS HWKGQVLNSD 70 80 90 100 110 120 ELQELYDGLK LNSVNQYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVMGDQR 130 140 150 160 170 180 DGEGAMYVPD DLLPVYREKV VPVADIITPN QFEAELLTGR KIHTQEEALE VMDMLHSMGP 190 200 210 220 230 240 DTVVITSSDL LSPRGSDYLM ALGSQRTRAP DGSMVTQRIR MEMHKVDAVF VGTGDLFAAM 250 260 270 280 290 300 LLAWTHKHPN NLKVACEKTV SAMHHVLQRT IKCAKAKSGE GVKPSPAQLE LRMVQSKKDI 310 ESPEIVVQAT VL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC122793 mRNA. Translation: AAI22794.1.
IPI	IPI00701044.
RefSeq	NP_001069119.1. NM_001075651.1.
UniGene	Bt.74137.
3D structure databases
ProteinModelPortal	Q0II59.
SMR	Q0II59. Positions 1-312.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0II59.
Proteomic databases
PRIDE	Q0II59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000024203; ENSBTAP00000024203; ENSBTAG00000018186.
GeneID	514168.
KEGG	bta:514168.
Organism-specific databases
CTD	8566.
Phylogenomic databases
eggNOG	maNOG07436.
GeneTree	ENSGT00390000003874.
HOVERGEN	HBG000732.
InParanoid	Q0II59.
OrthoDB	EOG4XPQGC.
PhylomeDB	Q0II59.
Family and domain databases
InterPro	IPR011611. Carb/pur_kinase. IPR004625. PyrdxlP_synth_PyrdxlKinase. [Graphical view]
KO	K00868.
PANTHER	PTHR10534. PTHR10534. 1 hit.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. Pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXK_BOVIN

Accession

Primary (citable) accession number: Q0II59

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 3, 2006
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program