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Protein

Pyridoxal kinase

Gene

PDXK

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for synthesis of pyridoxal-5-phosphate from vitamin B6.By similarity

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Divalent metal cations. Zn2+ is more efficient than Mg2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121SubstrateBy similarity
Binding sitei47 – 471SubstrateBy similarity
Binding sitei127 – 1271SubstrateBy similarity
Binding sitei235 – 2351SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 1872ATPBy similarity
Nucleotide bindingi223 – 23412ATPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-964975. Vitamins B6 activation to pyridoxal phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal kinase (EC:2.7.1.35)
Alternative name(s):
Pyridoxine kinase
Gene namesi
Name:PDXK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Pyridoxal kinasePRO_0000268830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei213 – 2131PhosphoserineBy similarity
Modified residuei285 – 2851PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0II59.
PeptideAtlasiQ0II59.
PRIDEiQ0II59.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018186.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024203.

Structurei

3D structure databases

ProteinModelPortaliQ0II59.
SMRiQ0II59. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxine kinase family.Curated

Phylogenomic databases

eggNOGiKOG2599. Eukaryota.
COG2240. LUCA.
GeneTreeiENSGT00390000003874.
HOGENOMiHOG000258174.
HOVERGENiHBG000732.
InParanoidiQ0II59.
KOiK00868.
OMAiVYQQKVV.
OrthoDBiEOG091G0EKE.
TreeFamiTF315004.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0II59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEECRVLSI QSHVVRGYVG NRAATFPLQV LGFEVDAVNS VQFSNHTGYS
60 70 80 90 100
HWKGQVLNSD ELQELYDGLK LNSVNQYDYV LTGYTRDKSF LAMVVDIVQE
110 120 130 140 150
LKQQNPRLVY VCDPVMGDQR DGEGAMYVPD DLLPVYREKV VPVADIITPN
160 170 180 190 200
QFEAELLTGR KIHTQEEALE VMDMLHSMGP DTVVITSSDL LSPRGSDYLM
210 220 230 240 250
ALGSQRTRAP DGSMVTQRIR MEMHKVDAVF VGTGDLFAAM LLAWTHKHPN
260 270 280 290 300
NLKVACEKTV SAMHHVLQRT IKCAKAKSGE GVKPSPAQLE LRMVQSKKDI
310
ESPEIVVQAT VL
Length:312
Mass (Da):34,817
Last modified:October 3, 2006 - v1
Checksum:i7FDD3E0153DFB7CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122793 mRNA. Translation: AAI22794.1.
RefSeqiNP_001069119.1. NM_001075651.2.
UniGeneiBt.74137.

Genome annotation databases

EnsembliENSBTAT00000024203; ENSBTAP00000024203; ENSBTAG00000018186.
GeneIDi514168.
KEGGibta:514168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122793 mRNA. Translation: AAI22794.1.
RefSeqiNP_001069119.1. NM_001075651.2.
UniGeneiBt.74137.

3D structure databases

ProteinModelPortaliQ0II59.
SMRiQ0II59. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024203.

Proteomic databases

PaxDbiQ0II59.
PeptideAtlasiQ0II59.
PRIDEiQ0II59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024203; ENSBTAP00000024203; ENSBTAG00000018186.
GeneIDi514168.
KEGGibta:514168.

Organism-specific databases

CTDi8566.

Phylogenomic databases

eggNOGiKOG2599. Eukaryota.
COG2240. LUCA.
GeneTreeiENSGT00390000003874.
HOGENOMiHOG000258174.
HOVERGENiHBG000732.
InParanoidiQ0II59.
KOiK00868.
OMAiVYQQKVV.
OrthoDBiEOG091G0EKE.
TreeFamiTF315004.

Enzyme and pathway databases

ReactomeiR-BTA-964975. Vitamins B6 activation to pyridoxal phosphate.

Gene expression databases

BgeeiENSBTAG00000018186.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDXK_BOVIN
AccessioniPrimary (citable) accession number: Q0II59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.