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Protein

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Gene

AIMP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation, Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Alternative name(s):
Multisynthase complex auxiliary component p38
Protein JTV-1
Gene namesi
Name:AIMP2
Synonyms:JTV1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168401 – 320Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues in response to UV irradiation.By similarity
Ubiquitinated by PRKN, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ0II26.
PeptideAtlasiQ0II26.
PRIDEiQ0II26.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007367.

Interactioni

Subunit structurei

Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Interacts (via N-terminus) with KARS. Interacts with EPRS. Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with PRKN/parkin (via first RING-type domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009687.

Structurei

3D structure databases

ProteinModelPortaliQ0II26.
SMRiQ0II26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 317GST C-terminalAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 162Interaction with PRKNBy similarityAdd BLAST81
Regioni162 – 225Interaction with TP53By similarityAdd BLAST64

Phylogenomic databases

eggNOGiENOG410II5D. Eukaryota.
ENOG4110B04. LUCA.
GeneTreeiENSGT00390000015826.
HOGENOMiHOG000015282.
InParanoidiQ0II26.
KOiK15438.
OMAiRVELPTC.
OrthoDBiEOG091G0Q05.
TreeFamiTF326322.

Family and domain databases

InterProiView protein in InterPro
IPR031889. AIMP2_LysRS-bd.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004046. GST_C.
PfamiView protein in Pfam
PF16780. AIMP2_LysRS_bd. 1 hit.
PF00043. GST_C. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0II26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMYQVKPYH EGSGSLRVEL PTCMYRLPNV HGRTGSPAPS ADHVQEASDP
60 70 80 90 100
SLQALESHQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPAA
110 120 130 140 150
LSTSTVDLNA MLGQDHGALK DIVINANPAS PPLSLLVLHR LLCDHYKVLS
160 170 180 190 200
SVHTHSAVRS VPANLLQCFG EQTRQQPRHE YQLGFTLIWK DVPKTQMKFS
210 220 230 240 250
VQTMCPIEGE GNIARFLFSL FGQKQDAVNL TLIDSWVDIA IFQLKEGSSK
260 270 280 290 300
EKAAVFRSMN SALGKTPWLV GDELTVADVV LWSVLRQTGG CGGMAPANVQ
310 320
KWMQACENLA PFHTALKLLQ
Length:320
Mass (Da):35,178
Last modified:October 3, 2006 - v1
Checksum:i13D1A507989F0E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122837 mRNA. Translation: AAI22838.1.
RefSeqiNP_001069281.1. NM_001075813.2.
UniGeneiBt.12468.

Genome annotation databases

EnsembliENSBTAT00000009687; ENSBTAP00000009687; ENSBTAG00000007367.
GeneIDi520979.
KEGGibta:520979.

Similar proteinsi

Entry informationi

Entry nameiAIMP2_BOVIN
AccessioniPrimary (citable) accession number: Q0II26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome