Reviewed, UniProtKB/Swiss-Prot Q0II25 (POP7_BOVIN)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein subunit p20
      Short name=RNaseP protein p20
    EC=3.1.26.5

Gene names

Name:	POP7
Synonyms:	RPP20

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25. RPP20/POP7 is probably a dimer By similarity.
Subcellular location	Nucleus › nucleolus Potential.
Sequence similarities	Belongs to the histone-like Alba family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Ribonuclease P protein subunit p20		PRO_0000271034

Sequences

	Sequence		Length	Mass (Da)
	Q0II25-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 7E4E130FF44B6BB4	FASTA	140	15,707
	10 20 30 40 50 60 MAENRESRGT VEAELDPVEY TLRKRLPHRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA 70 80 90 100 110 120 RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDSREP 130 140 LTRIRNNSAI HIRVFRVTPK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC122839 mRNA. Translation: AAI22840.1.
IPI	IPI00697064.
RefSeq	NP_001069950.1.
UniGene	Bt.22841
3D structure databases
SMR	Q0II25. Positions 34-137.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0II25.
Genome annotation databases
Ensembl	ENSBTAT00000037231; ENSBTAP00000037068; ENSBTAG00000026248; Bos taurus. [Genome view]
GeneID	617906.
KEGG	bta:617906.
Organism-specific databases
CTD	617906.
Phylogenomic databases
eggNOG	maNOG19727.
HOVERGEN	Q0II25.
InParanoid	Q0II25.
OMA	CTEIYIH.
OrthoDB	EOG9D81S0.
PhylomeDB	Q0II25.
Enzyme and pathway databases
BRENDA	3.1.26.5. 251.
Family and domain databases
InterPro	IPR014612. RNase_P/MRP_p20. [Graphical view]
PIRSF	PIRSF036572. RPP20. 1 hit.
ProtoNet	Search...

Entry information

Entry name

POP7_BOVIN

Accession

Primary (citable) accession number: Q0II25

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 3, 2006
Last modified:	January 19, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)