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Protein

Inverted formin-2

Gene

inf2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inverted formin-2
Gene namesi
Name:inf2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5862185. inf2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002598921 – 1380Inverted formin-2Add BLAST1380

Proteomic databases

PaxDbiQ0IHV1.

Expressioni

Gene expression databases

BgeeiENSXETG00000008613.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000018819.

Structurei

3D structure databases

ProteinModelPortaliQ0IHV1.
SMRiQ0IHV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 330GBD/FH3PROSITE-ProRule annotationAdd BLAST330
Domaini432 – 592FH1Add BLAST161
Domaini593 – 981FH2PROSITE-ProRule annotationAdd BLAST389
Domaini1009 – 1024WH2PROSITE-ProRule annotationAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili879 – 930Sequence analysisAdd BLAST52
Coiled coili956 – 991Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi405 – 566Pro-richAdd BLAST162
Compositional biasi741 – 744Poly-Leu4

Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
ENOG410XQR0. LUCA.
GeneTreeiENSGT00760000118986.
HOGENOMiHOG000074184.
HOVERGENiHBG081795.
InParanoidiQ0IHV1.
OMAiHKVSCSP.
OrthoDBiEOG091G04GZ.
TreeFamiTF326300.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR014768. GBD/FH3_dom.
IPR010473. GTPase-bd.
IPR027649. Inf2.
IPR003124. WH2_dom.
PANTHERiPTHR23213:SF5. PTHR23213:SF5. 2 hits.
PfamiView protein in Pfam
PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
PF02205. WH2. 1 hit.
SMARTiView protein in SMART
SM01139. Drf_FH3. 1 hit.
SM01140. Drf_GBD. 1 hit.
SM00498. FH2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
PS51082. WH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0IHV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKEGAHTK WGVLKQKLGP QDPEQIEGNM ENADPELCIR LLQIPSVVNY
60 70 80 90 100
SGLKKRLESS DDDWMVQFLE LSGLDLLLEA LDRLSGRGVA RIADALLQLT
110 120 130 140 150
CINCVRTLMN SHRGIEYIVN NEGYVRKLSQ ALDTSNVMVK KQVFELLAAL
160 170 180 190 200
CIYSPEGHAL SLDALEHYKA VKNQQYRFSV IMNELSTSDN VPYMVTLLSA
210 220 230 240 250
INAIIFGTEE LRKRVQLRNE FIGLQLLDLL TKLRDLEDED LLIQAIVFEE
260 270 280 290 300
AKSEDEEELL KIYGGIDMNN HQEVFSTLFN KVSCSPLSVQ LLSVLQGLLH
310 320 330 340 350
LDQSHPSSPL LWEALDILVN RAVLLADDCQ NNNVEEVMDR LVTSKKHPSK
360 370 380 390 400
EKRKPDKCTN QVNKSIQTDK PKDESCEEKT VKKDPVSSGI PADSLQLSDA
410 420 430 440 450
LLALPACVSP LHTPLSGDIT SPSHFPSPPS PVVSNAIDRI STSSSLPPPL
460 470 480 490 500
PPPLPGTELS LPPPPPPPLP GMGGISLTPP PPPPLPGMGG MLPPPPPPLP
510 520 530 540 550
GMGGMLPPPP PPLPGMGGML PPPPPPLPGM GGMLPPPPPP LPGMGGMPPP
560 570 580 590 600
PPPLPGMGGM PPPPPPMFGM GTFTDEVVVA RVDYSLGYLP KAYFKVNKPT
610 620 630 640 650
LKMKKLNWQK LPPNVINDTH SMWASASSSN DTPEPNYSSI EQLFCLPQAV
660 670 680 690 700
AKEPAAPVKK PPKEISFLDS KKNLNLNIFL KQFKCPNEEV IQLIEKGDRS
710 720 730 740 750
RFDIEILKQF LKLLPEKHEV ENLKSYQEDK AKLSNADQFY LLLLGIPCYQ
760 770 780 790 800
LRIECMLICE EVNLMTDVLR PKAKVVSSAC DDIISSHRLP LFCQLILKVG
810 820 830 840 850
NFLNYGSHTG NANGFKIGTL LKLTETKANQ NRITLLHHIL EEIEQNHTDL
860 870 880 890 900
LQLPSDLENV STAAGINIEN MYSETSGNLK KLRDLQNKIS TAATDVKDQY
910 920 930 940 950
EKSIQECMDA LKEVEEQLTD ITQKKVKLAD YLCEDSAKLS LEETFSTMKA
960 970 980 990 1000
FRDLFLKAKK DNKDRKEQAV KAEKRKKQLA DEEAKRQKGE NGKIIRKGAA
1010 1020 1030 1040 1050
KLEEGCIIDA LLADIKKGFQ LRKTAKTKTE ADSCPKPVSS ETTGTDGTDV
1060 1070 1080 1090 1100
KHVDHVGILP QIKLDSSLNL DGTEQHKSKS KDNCGENFDN KPVVIAPINL
1110 1120 1130 1140 1150
DTSACLMNIS EQNAKLPVSA LQEGANLKQN PDTFVKEQSA IVTTESSTHN
1160 1170 1180 1190 1200
NIDGSSVDKC TLGQSQWPSE ISDEVDSKYH EMPMQVEHKE RAVEGKCSLP
1210 1220 1230 1240 1250
KPSVLGTESS SNQNNALNEG SQQHHNNTAN ESLQQAQNSA LSEASQQSCC
1260 1270 1280 1290 1300
HTGIKGSPQF QSSALNADSQ PSHTSVVGSA QAQRNELDDV ALQTRDTTVT
1310 1320 1330 1340 1350
EGSQVEEDKC NDEGYPEHKT MGEHPLNSSS HSTTLQQSSE DGQKVKRGSS
1360 1370 1380
KHKKKRRSSK HGEEDGVDSP THKTRGCVVQ
Length:1,380
Mass (Da):151,537
Last modified:October 3, 2006 - v1
Checksum:i3314CA4E6848FB6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122958 mRNA. Translation: AAI22959.1.
RefSeqiNP_001072591.1. NM_001079123.1.
XP_012824085.1. XM_012968631.2.
XP_012824086.1. XM_012968632.2.
XP_012824087.1. XM_012968633.2.
XP_017951812.1. XM_018096323.1.
UniGeneiStr.52470.

Genome annotation databases

EnsembliENSXETT00000018819; ENSXETP00000018819; ENSXETG00000008613.
GeneIDi780046.
KEGGixtr:780046.

Similar proteinsi

Entry informationi

Entry nameiINF2_XENTR
AccessioniPrimary (citable) accession number: Q0IHV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families