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Protein

Palmitoyltransferase

Gene

CG4676

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
ORF Names:CG4676Imported, Dmel_CG4676Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033815. CG4676.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 75HelicalUniRule annotationAdd BLAST24
Transmembranei142 – 165HelicalUniRule annotationAdd BLAST24
Transmembranei197 – 222HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0033815.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086856.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 229zf-DHHCInterPro annotationAdd BLAST134

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
KOiK18932.
OMAiFVPVTYI.
OrthoDBiEOG091G0RWR.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0IGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMILRSWDRV KPRSISDFAC FLLVAVFVPV TYIFHVTIVM PELFAIGGIW
60 70 80 90 100
YTLLWLASLF LIFNITSNML ACMLVDTSIR KELLKPPLDA AQLARWHSCQ
110 120 130 140 150
DCQTLVPPRS WHCEVCNVCV LKRDHHCRFT CCCIGHHNYR YFFYYLVYMI
160 170 180 190 200
IGSLAAAIME SIYLWHLHLD IYWRWSTLFT IFAPVVSLML SPSWESFYLV
210 220 230 240 250
IYDLTLLGFA ISSLLLVFHW SIFKSGSVTR ERGTRKYDRG LRGNLEMVLG
260 270 280
KRMHLTWLSP FLRSDLPHDG MNWEPIAAFS PKEE
Length:284
Mass (Da):33,223
Last modified:November 14, 2006 - v2
Checksum:i6D80F7DD7859A01E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58399.1.
BT028843 mRNA. Translation: ABI34224.2.
RefSeqiNP_610853.1. NM_137009.3.
UniGeneiDm.16102.

Genome annotation databases

EnsemblMetazoaiFBtr0087743; FBpp0086856; FBgn0033815.
GeneIDi36465.
KEGGidme:Dmel_CG4676.
UCSCiCG4676-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58399.1.
BT028843 mRNA. Translation: ABI34224.2.
RefSeqiNP_610853.1. NM_137009.3.
UniGeneiDm.16102.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087743; FBpp0086856; FBgn0033815.
GeneIDi36465.
KEGGidme:Dmel_CG4676.
UCSCiCG4676-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0033815. CG4676.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
KOiK18932.
OMAiFVPVTYI.
OrthoDBiEOG091G0RWR.

Miscellaneous databases

GenomeRNAii36465.

Gene expression databases

BgeeiFBgn0033815.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ0IGS7_DROME
AccessioniPrimary (citable) accession number: Q0IGS7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: November 14, 2006
Last modified: April 12, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.