Q0IFY6 (Q0IFY6_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methionine aminopeptidase RuleBase RU003653
EC=3.4.11.18 RuleBase RU003653

Gene names

ORF Names:

AAEL003769, AaeL_AAEL003769 EMBL EAT44938.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the N-terminal methionine from nascent proteins By similarity. RuleBase RU003653
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. RuleBase RU003653
Cofactor	Binds 2 cobalt ions per subunit By similarity. RuleBase RU003653
Sequence similarities	Belongs to the peptidase M24A family. RuleBase RU003653

Ontologies

Keywords
Ligand	Cobalt RuleBase RU003653 Metal-binding RuleBase RU003653
Molecular function	Aminopeptidase RuleBase RU003653 EMBL EAT44938.1 Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0IFY6 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 8566C11CA40E7220	FASTA	371	42,106
	10 20 30 40 50 60 MQHQCETENC KNTATLQCPV CLKMGIQGSY FCGQDCFKSS WKGHKVIHLL AKGKEDKNVY 70 80 90 100 110 120 NPWPYYTFTG KLRPFPQSEK RPVPERIPRP DYADHKEGRS KSEESLRGNT TIKILDDEEK 130 140 150 160 170 180 EGMRVACRLG REVLDEAARV CDVGVTTDEI DRIVHEACIE RECYPSPLNY YNFPKSCCTS 190 200 210 220 230 240 VNEVICHGIP DMRPLEDGDL CNVDVTVYHR GFHGDLNETF FVGNVKEQHK KLVQVTHEAL 250 260 270 280 290 300 MKAIAIVKPG ERYREIGNVI QKHVHAHGFS VVKSYCGHGI HRLFHTAPNV PHYAKNNAVG 310 320 330 340 350 360 VMKPGHCFTI EPMISEGSWR DVSWPDDWTA VTADGLFSAQ FEQTLLVTET GCDILTLRRN 370 SNGQPHFMDK L

References

[1]

"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVPib12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH477281 Genomic DNA. Translation: EAT44938.1.
RefSeq	XP_001657229.1. XM_001657179.1.
UniGene	Aae.10582. Aae.22277.
3D structure databases
ProteinModelPortal	Q0IFY6.
SMR	Q0IFY6. Positions 66-368.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0IFY6.
Protein family/group databases
MEROPS	M24.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AAEL003769-RB; AAEL003769-PB; AAEL003769.
GeneID	5578941.
KEGG	aag:AaeL_AAEL003769.
VectorBase	AAEL003769. Aedes aegypti.
Phylogenomic databases
GeneTree	EMGT00050000007785.
OMA	IEPMISE.
PhylomeDB	Q0IFY6.
Family and domain databases
InterPro	IPR001714. Pept_M24_MAP. IPR000994. Pept_M24_structural-domain. IPR002467. Pept_M24A_MAP1. [Graphical view]
Gene3D	G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KO	K01265.
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
PRINTS	PR00599. MAPEPTIDASE.
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMs	TIGR00500. Met_pdase_I. 1 hit.
PROSITE	PS00680. MAP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0IFY6_AEDAE

Accession

Primary (citable) accession number: Q0IFY6

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)