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Q0IFL5 (ASSY_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
ORF Names:AAEL004701
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
Urea cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000321326

Regions

Nucleotide binding10 – 189ATP By similarity
Nucleotide binding115 – 1239ATP By similarity

Sites

Binding site361ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site871Citrulline By similarity
Binding site921Citrulline By similarity
Binding site1191Aspartate By similarity
Binding site1231Aspartate By similarity
Binding site1231Citrulline By similarity
Binding site1241Aspartate By similarity
Binding site1271Citrulline By similarity
Binding site1801Citrulline By similarity
Binding site1891Citrulline By similarity
Binding site2701Citrulline By similarity
Binding site2821Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IFL5 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: BB9595CF2605F70F

FASTA41245,989
        10         20         30         40         50         60 
MSGKEKILLA YSGGLDTSCI LKWLLEKGYE VICFMADVGQ EEDFVAAREK ALRVGAKDVI 

        70         80         90        100        110        120 
IKDMKRIFVE KFVWPAIQMG LVYEDRYLLG TSLARPCISI GLMESAAEHS CSIISHGATG 

       130        140        150        160        170        180 
KGNDQIRFEL SCYALDPKIK VIAPWRLPEF CERFQGRKDL LDYAQKHGIP VSATPKAPWS 

       190        200        210        220        230        240 
MDANIMHISY ESGILENPAK AAPEELYQMT QSVMKSSNTP IKVDITFKEG LPVTVLEHSG 

       250        260        270        280        290        300 
GKTLETPLEV LTFLNKIGGE QGVGRVDLVE NRFLGLKSRG VYETPGATIL HVAHKDMEVY 

       310        320        330        340        350        360 
CLDREIFRVK SFLALKMADY VYNGFWYSPE AEYVRTCLVG AQKNVSGKVT LEIFKGHVIA 

       370        380        390        400        410 
IARESTKTIY NQELASMDVH GTLSPYAATG FIEVNAMRLK EHYRVFGSAN ME 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH477312 Genomic DNA. Translation: EAT43888.1.
RefSeqXP_001649600.1. XM_001649550.1.
UniGeneAae.10323.

3D structure databases

ProteinModelPortalQ0IFL5.
SMRQ0IFL5. Positions 4-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7159.AAEL004701-PA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL004701-RA; AAEL004701-PA; AAEL004701.
GeneID5565274.
KEGGaag:AaeL_AAEL004701.
VectorBaseAAEL004701. Aedes aegypti.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAGIKSKFD.
OrthoDBEOG7PVWPB.
PhylomeDBQ0IFL5.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.
UPA00158; UER00272.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_AEDAE
AccessionPrimary (citable) accession number: Q0IFL5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways