Q0IE19 (Q0IE19_SYNS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 1 HAMAP MF_00444

Gene names

Name:	clpP-1 EMBL ABI46166.1
Synonyms:	clpP1 HAMAP MF_00444
Ordered Locus Names:	sync_0065

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP] EMBL ABI46166.1

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	125	1	By similarity HAMAP MF_00444
	Active site	150	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	Q0IE19 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 34FCAE837CB8B25C	FASTA	229	24,663
	10 20 30 40 50 60 MINARSHHPI ENRWRGTLPV SAHTPHASPG VPTVVEQSGR GERSFDIYSR LLRERIIFLG 70 80 90 100 110 120 TDVNDQVADA LVAQLLFLEA EDPEKDIQVY INSPGGSITA GLAIYDTMQQ VAPDVVTICY 130 140 150 160 170 180 GLAASMGAFL LSGGCKGKRL ALPNARIMIH QPLGGAQGQA VDIEIMAQEI LFLKETLNGL 190 200 210 220 MADHTGQPLA KITEDTERDY FLSPAEAVEY GLIDRVVDNL GGEGIITGG

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI46166.1.
RefSeq	YP_729303.1. NC_008319.1.
3D structure databases
ProteinModelPortal	Q0IE19.
SMR	Q0IE19. Positions 31-217.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0IE19.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4260387.
GenomeReviews	Gene locus sync_0065 in contig CP000435_GR.
KEGG	syg:sync_0065.
PATRIC	23790966. VBISynSp88089_0069.
TIGR	sync_0065.
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	NAICAQL.
PhylomeDB	Q0IE19.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0IE19_SYNS3

Accession

Primary (citable) accession number: Q0IE19

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)