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Q0IDE8

- PUR9_SYNS3

UniProt

Q0IDE8 - PUR9_SYNS3

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSSP64471:GIVP-289-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:sync_0289
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000018980Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_0289.

Structurei

3D structure databases

ProteinModelPortaliQ0IDE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0IDE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPTALLSVS DKRGVVPLAE ALHRLHGYQL LSSGGTAKVL QEAGLPVTRV
60 70 80 90 100
ADHTGAPEIL GGRVKTLHPR IHGGILARRG DPAHEADLLE QQIDPIDVVV
110 120 130 140 150
VNLYPFRETV ATPDVSWDAA IENIDIGGPT MVRSAAKNHA HVAVLTSPEQ
160 170 180 190 200
YDRFLKALSG SAGGVNANVR RQLALEAFAH TAAYDVAISR WMQSRPELQP
210 220 230 240 250
DVEAAAPAEA LPWLEALPLR QTLRYGENPH QKAAWFSSPM GWGGAKQLQG
260 270 280 290 300
KALSTNNLLD LEAALATVRE FGYGSSGLHP AQQAAAVVVK HTNPCGVAVG
310 320 330 340 350
DGVGIALTRA LDGDRISAFG GIVALNAVVD GPAAKELTSL FLECVVAPGY
360 370 380 390 400
SSEALEILAA KGNLRLLELP PEAIDAAPKD HVRSILGGVL VQDLDDQPID
410 420 430 440 450
PSAWTVASQR QPTTAETADL RFAWQLVRHV RSNAILVARD GQSLGVGAGQ
460 470 480 490 500
MNRVGSARIA LEAAGEQAVG AVLASDGFFP FDDTVRLAAS HGIKAVIHPG
510 520
GSLRDADSIK ACDELGLAMV LTGRRHFLH
Length:529
Mass (Da):55,772
Last modified:October 3, 2006 - v1
Checksum:i01579B74B08DD49E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI46591.1.
RefSeqiWP_011618269.1. NC_008319.1.
YP_729524.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI46591; ABI46591; sync_0289.
GeneIDi4259254.
KEGGisyg:sync_0289.
PATRICi23791432. VBISynSp88089_0299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI46591.1 .
RefSeqi WP_011618269.1. NC_008319.1.
YP_729524.1. NC_008319.1.

3D structure databases

ProteinModelPortali Q0IDE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64471.sync_0289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI46591 ; ABI46591 ; sync_0289 .
GeneIDi 4259254.
KEGGi syg:sync_0289.
PATRICi 23791432. VBISynSp88089_0299.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SSP64471:GIVP-289-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiPUR9_SYNS3
AccessioniPrimary (citable) accession number: Q0IDE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3