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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35S-adenosyl-L-methionineUniRule annotation1
Binding sitei60S-adenosyl-L-methionineUniRule annotation1
Binding sitei87S-adenosyl-L-methionineUniRule annotation1
Active sitei113By similarity1
Binding sitei113S-adenosyl-L-methionineUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP64471:G1G72-321-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:sync_0328
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001961 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882421 – 237tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST237

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_0328

Structurei

3D structure databases

ProteinModelPortaliQ0IDB0
SMRiQ0IDB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107YD0 Bacteria
COG0220 LUCA
HOGENOMiHOG000237936
KOiK03439
OMAiQFPDPWF
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q0IDB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQHVNPLSR FFQLPLELPA PHELFEHPNL PIHLDIGCAR GFFLLELAAM
60 70 80 90 100
QPERNHLGVE IRRPLVQAAQ HDRDRQEQHN LHFLFCNANI SLEAWMAALP
110 120 130 140 150
PDQLQLVSIQ FPDPWFKQRH RKRRVLQPAL LLAIAAALHP GRHLFLQSDV
160 170 180 190 200
LAVIEPMVAL VELSNCFARP KDDPQPWRSS NPLPVATERE RYVQEQGQPT
210 220 230
YRVLFERTQA ELPALRDLEM AWQQVDNSKD AAPTPHG
Length:237
Mass (Da):27,319
Last modified:October 3, 2006 - v1
Checksum:iE6D88F5D695FBEAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA Translation: ABI47587.1
RefSeqiWP_011618304.1, NC_008319.1

Genome annotation databases

EnsemblBacteriaiABI47587; ABI47587; sync_0328
KEGGisyg:sync_0328

Similar proteinsi

Entry informationi

Entry nameiTRMB_SYNS3
AccessioniPrimary (citable) accession number: Q0IDB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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