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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathway: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase (glutamine-hydrolyzing) (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSSP64471:GIVP-343-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:sync_0343
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Aspartate carbamoyltransferasePRO_0000301632Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_0343.

Structurei

3D structure databases

ProteinModelPortaliQ0ID96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ID96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWSHRHVL DLASFSRDDY ATVLELAHRF RSMPVTGARK LPALQGRLVA
60 70 80 90 100
TLFFEPSTRT RSSFELAAKR LSADVQSFSP SSSSLSKGES LLDTARTYVA
110 120 130 140 150
MGADVLVIRH RCTDVPAQLA SELDQAGERT VVLNGGDGQH SHPSQGLLDL
160 170 180 190 200
YTLAHHFDPR NSQLDALQGK RIVIVGDVVH SRVARSNLWA LSACGADVVL
210 220 230 240 250
CGPPSLVPDA FAAFLDAPPP GQASDPVRER GTVQISRSLD DCLSGADAVM
260 270 280 290 300
TLRLQKERMT DHLLTNLDRY HRDFGLTHER LRRCAFSGPV LHPGPVNRGV
310 320 330 340
EMSGGLLDDR SICLVEDQVR NGIPIRMALL YLMAASDPVA ESSRASAPS
Length:349
Mass (Da):37,879
Last modified:October 3, 2006 - v1
Checksum:i7A59A091FD1C2CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI46806.1.
RefSeqiWP_011618317.1. NC_008319.1.
YP_729576.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI46806; ABI46806; sync_0343.
KEGGisyg:sync_0343.
PATRICi23791540. VBISynSp88089_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI46806.1.
RefSeqiWP_011618317.1. NC_008319.1.
YP_729576.1. NC_008319.1.

3D structure databases

ProteinModelPortaliQ0ID96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64471.sync_0343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI46806; ABI46806; sync_0343.
KEGGisyg:sync_0343.
PATRICi23791540. VBISynSp88089_0351.

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciSSP64471:GIVP-343-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiPYRB_SYNS3
AccessioniPrimary (citable) accession number: Q0ID96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 3, 2006
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.