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Q0ICW4

- PUR5_SYNS3

UniProt

Q0ICW4 - PUR5_SYNS3

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, sync_0481
Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP64471:GIVP-481-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:sync_0481
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000046481Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_0481.

Structurei

3D structure databases

ProteinModelPortaliQ0ICW4.
SMRiQ0ICW4. Positions 1-335.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0ICW4-1 [UniParc]FASTAAdd to Basket

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MDYKTAGVDV EAGRAFVNRI RKSVEATHRP EVVGGLGGFG GLMRLPAGLK    50
KPLLVSGTDG VGTKLELAQD HGGHHNVGID LVAMCVNDVI TSGAEPLFFL 100
DYMATGALSP EAMATVVEGI AEGCRGSGCA LLGGETAEMP GFYPSGRYDL 150
AGFCVAVVEE EQLIDGRQIR AGDRILGIAS SGIHSNGFSL VRRVLTHAGA 200
NAETTFGPSN QPLIESLLTP TQLYGRLVKT LLETGTPIHG MAHITGGGLP 250
ENLPRCLPEG LQAIVTPSSW TRPAIYDWLQ SHGDIPERDL WHTFNLGIGY 300
CLIVPEEGVS IAEKACESEG MQAWTIGRIE ASSGGDGKGS VLGLPA 346
Length:346
Mass (Da):36,298
Last modified:October 3, 2006 - v1
Checksum:i21B26FED8BBA7C9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI47623.1.
RefSeqiWP_011618440.1. NC_008319.1.
YP_729708.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI47623; ABI47623; sync_0481.
GeneIDi4259731.
KEGGisyg:sync_0481.
PATRICi23791820. VBISynSp88089_0487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI47623.1 .
RefSeqi WP_011618440.1. NC_008319.1.
YP_729708.1. NC_008319.1.

3D structure databases

ProteinModelPortali Q0ICW4.
SMRi Q0ICW4. Positions 1-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64471.sync_0481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI47623 ; ABI47623 ; sync_0481 .
GeneIDi 4259731.
KEGGi syg:sync_0481.
PATRICi 23791820. VBISynSp88089_0487.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SSP64471:GIVP-481-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiPUR5_SYNS3
AccessioniPrimary (citable) accession number: Q0ICW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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