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Q0ICW2

- PANCY_SYNS3

UniProt

Q0ICW2 - PANCY_SYNS3

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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Displays a CMP kinase activity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141Proton donorUniRule annotation
Binding sitei41 – 411Beta-alanineUniRule annotation
Binding sitei41 – 411PantoateUniRule annotation
Binding sitei136 – 1361PantoateUniRule annotation
Binding sitei159 – 1591ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPUniRule annotation
Nucleotide bindingi130 – 1334ATPUniRule annotation
Nucleotide bindingi167 – 1704ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP64471:GIVP-483-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:sync_0483
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Bifunctional pantoate ligase/cytidylate kinasePRO_0000333300Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_0483.

Structurei

3D structure databases

ProteinModelPortaliQ0ICW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 258258Pantoate--beta-alanine ligaseAdd
BLAST
Regioni259 – 494236Cytidylate kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0ICW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHFVPTMGGL HHGHASLISA ASCHKSGDVE TLVSVFVNPL QFGPNEDFAR
60 70 80 90 100
YPRTFEADCE LAELSGASAI WCPDESQIYP GGSAESWRIQ APKSLQSRLC
110 120 130 140 150
GSTRPGHFDG VVTVVCRLLA LAKPHQLFLG EKDWQQLTIL RRMVLDLGLA
160 170 180 190 200
VRVRGVPTVR DGDGLASSSR NRYLNAQQRQ QGVLFAQVLS DARSACLHGG
210 220 230 240 250
TALKPGEVKR RLEEVGLSVE YVDVVDPWFL QPSKSNQSSL TLLAAAVRCG
260 270 280 290 300
STRLIDHAFL MTRSPLVAID GPAGAGKSTV TRAFAERLGL VYLDTGAMYR
310 320 330 340 350
AVTWLVLEQG GDPGDSEAVD LVLNDLKVEL EPLQQGVQVV RVNGHEVTDA
360 370 380 390 400
IRDPRVTASV SAVASHACVR AAMTAQQQRM GKAGGLVAEG RDIGTAVFPD
410 420 430 440 450
AELKVFLTAT PKERARRRAL DLEARGHEVP ALPELEAQIV ERDRLDSTRE
460 470 480 490
VAPLLQADDA IELISDGMSI DQVIDALEDL FRRRVGEEVW PTPV
Length:494
Mass (Da):53,594
Last modified:October 3, 2006 - v1
Checksum:iE7EDD078F93465E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI45138.1.
RefSeqiWP_011618442.1. NC_008319.1.
YP_729710.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI45138; ABI45138; sync_0483.
GeneIDi4260685.
KEGGisyg:sync_0483.
PATRICi23791826. VBISynSp88089_0490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI45138.1 .
RefSeqi WP_011618442.1. NC_008319.1.
YP_729710.1. NC_008319.1.

3D structure databases

ProteinModelPortali Q0ICW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64471.sync_0483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI45138 ; ABI45138 ; sync_0483 .
GeneIDi 4260685.
KEGGi syg:sync_0483.
PATRICi 23791826. VBISynSp88089_0490.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci SSP64471:GIVP-483-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiPANCY_SYNS3
AccessioniPrimary (citable) accession number: Q0ICW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3