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Q0ICW2

- PANCY_SYNS3

UniProt

Q0ICW2 - PANCY_SYNS3

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
    Displays a CMP kinase activity.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
    ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei14 – 141Proton donorUniRule annotation
    Binding sitei41 – 411Beta-alanineUniRule annotation
    Binding sitei41 – 411PantoateUniRule annotation
    Binding sitei136 – 1361PantoateUniRule annotation
    Binding sitei159 – 1591ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 148ATPUniRule annotation
    Nucleotide bindingi130 – 1334ATPUniRule annotation
    Nucleotide bindingi167 – 1704ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP64471:GIVP-483-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
    Including the following 2 domains:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
    Short name:
    CKUniRule annotation
    Alternative name(s):
    Cytidine monophosphate kinaseUniRule annotation
    Short name:
    CMP kinaseUniRule annotation
    Gene namesi
    Name:panC/cmkUniRule annotation
    Ordered Locus Names:sync_0483
    OrganismiSynechococcus sp. (strain CC9311)
    Taxonomic identifieri64471 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001961: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Bifunctional pantoate ligase/cytidylate kinasePRO_0000333300Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi64471.sync_0483.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0ICW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 258258Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni259 – 494236Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0ICW2-1 [UniParc]FASTAAdd to Basket

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    MHFVPTMGGL HHGHASLISA ASCHKSGDVE TLVSVFVNPL QFGPNEDFAR    50
    YPRTFEADCE LAELSGASAI WCPDESQIYP GGSAESWRIQ APKSLQSRLC 100
    GSTRPGHFDG VVTVVCRLLA LAKPHQLFLG EKDWQQLTIL RRMVLDLGLA 150
    VRVRGVPTVR DGDGLASSSR NRYLNAQQRQ QGVLFAQVLS DARSACLHGG 200
    TALKPGEVKR RLEEVGLSVE YVDVVDPWFL QPSKSNQSSL TLLAAAVRCG 250
    STRLIDHAFL MTRSPLVAID GPAGAGKSTV TRAFAERLGL VYLDTGAMYR 300
    AVTWLVLEQG GDPGDSEAVD LVLNDLKVEL EPLQQGVQVV RVNGHEVTDA 350
    IRDPRVTASV SAVASHACVR AAMTAQQQRM GKAGGLVAEG RDIGTAVFPD 400
    AELKVFLTAT PKERARRRAL DLEARGHEVP ALPELEAQIV ERDRLDSTRE 450
    VAPLLQADDA IELISDGMSI DQVIDALEDL FRRRVGEEVW PTPV 494
    Length:494
    Mass (Da):53,594
    Last modified:October 3, 2006 - v1
    Checksum:iE7EDD078F93465E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI45138.1.
    RefSeqiWP_011618442.1. NC_008319.1.
    YP_729710.1. NC_008319.1.

    Genome annotation databases

    EnsemblBacteriaiABI45138; ABI45138; sync_0483.
    GeneIDi4260685.
    KEGGisyg:sync_0483.
    PATRICi23791826. VBISynSp88089_0490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI45138.1 .
    RefSeqi WP_011618442.1. NC_008319.1.
    YP_729710.1. NC_008319.1.

    3D structure databases

    ProteinModelPortali Q0ICW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64471.sync_0483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI45138 ; ABI45138 ; sync_0483 .
    GeneIDi 4260685.
    KEGGi syg:sync_0483.
    PATRICi 23791826. VBISynSp88089_0490.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci SSP64471:GIVP-483-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9311.

    Entry informationi

    Entry nameiPANCY_SYNS3
    AccessioniPrimary (citable) accession number: Q0ICW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3