Q0IBI6 (Q0IBI6_SYNS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA-2 EMBL ABI45101.1
Synonyms:	gyrA HAMAP MF_01897
Ordered Locus Names:	sync_0973

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP] EMBL ABI45101.1

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	892 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0IBI6 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: FE185849AA12D3B7	FASTA	892	97,327
	10 20 30 40 50 60 MADPVGPGSG GPGESDDRII QTDLRNEMSR SYLEYAMSVI VGRALPDARD GLKPVHRRIL 70 80 90 100 110 120 YAMYELGLTS DRPYRKCARV VGEVLGKYHP HGDTAVYDAL VRMAQDFSMS MPLIDGHGNF 130 140 150 160 170 180 GSVDNDPPAA MRYTESRLQA LTTDSLLEDI EAETVDFADN FDGSQQEPTV LPSRIPQLLL 190 200 210 220 230 240 NGSAGIAVGM ATNIPPHNLG ELITGLLALI RNPEITDQEL MALIPGPDFP TGGQILGRSG 250 260 270 280 290 300 IRETYLTGRG SVTMRGVAGI ETIEAPGRPD RDAVVITALP YQTNKAAMIE RIAEMVNDKK 310 320 330 340 350 360 LEGISDIRDE SDRDGMRVVV ELRRDAYPQV VLNNLYKLTP LQSNFSAHML ALVNSEPILL 370 380 390 400 410 420 TLRKMLEVFL EFRVETIERR TRYLLRKAEE RDHILLGLLL ALDQLDPIIA LIRAAPDTAT 430 440 450 460 470 480 ARTQLQERHG LSAVQADAIL QMQLRRLTAL EADKIRLEHE DLVTKIADYK DILGRRERVF 490 500 510 520 530 540 GIIEDELGQL RDRHAVPRRT EILDLAGGLE DIDLIANERS VVLLTETGYL KRMPVSEFEA 550 560 570 580 590 600 TSRGTRGKAG TRSQGEEAVK LFIGCNDHDT LLLFSDRGVS YAVPAYRVPQ CSRTAKGTPI 610 620 630 640 650 660 VQLLPIPREE AITSLLAVSE FNDDTDLLML TTGGYIKRTR LSAFSNIRSN GLIAIGLEEG 670 680 690 700 710 720 DALTWVRLAV PGDSVLIGSR AGMTIHFRLS DNELRPLGRT ARGVRSMNLR EGDSLVSMDV 730 740 750 760 770 780 LPAELADQIA ASVDEDDEGS DGGESAAAEG PWVLVASASG LGKRVPVTQF RLQKRAGMGL 790 800 810 820 830 840 RAMKFRTDAD ELVGLRVLGA GEELLLVSEK GVIVRTGADA IPQQSRAATG VRLQRLDKGD 850 860 870 880 890 RLADVVLVPP EAETDDDTES DSAGEPNSNS APDVVAEQAA TPEDLSEPSA ED

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI45101.1.
RefSeq	YP_730186.1. NC_008319.1.
3D structure databases
ProteinModelPortal	Q0IBI6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0IBI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4260767.
GenomeReviews	Gene locus sync_0973 in contig CP000435_GR.
KEGG	syg:sync_0973.
PATRIC	23792906. VBISynSp88089_1017.
TIGR	sync_0973.
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q0IBI6.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0IBI6_SYNS3

Accession

Primary (citable) accession number: Q0IBI6

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)