ID   ACSF_SYNS3              Reviewed;         360 AA.
AC   Q0IAL0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
GN   Name=acsF; OrderedLocusNames=sync_1304;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F.,
RA   Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J.,
RA   Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y.,
RA   Halpin R., Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to
RT   a coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in
CC       chlorophyll biosynthesis. Mediates the cyclase reaction, which
CC       results in the formation of divinylprotochlorophyllide (Pchlide)
CC       characteristic of all chlorophylls from magnesium-protoporphyrin
CC       IX 13-monomethyl ester (MgPMME) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl
CC       ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX
CC       13-monomethyl ester + NADP(+) + H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-
CC       protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide +
CC       NADP(+) + 2 H(2)O.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-
CC       independent).
CC   -!- SIMILARITY: Belongs to the acsF family.
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DR   EMBL; CP000435; ABI47230.1; -; Genomic_DNA.
DR   RefSeq; YP_730512.1; -.
DR   GeneID; 4260235; -.
DR   GenomeReviews; CP000435_GR; sync_1304.
DR   KEGG; syg:sync_1304; -.
DR   TIGR; sync_1304; -.
DR   HOGENOM; Q0IAL0; -.
DR   OMA; Q0IAL0; SMSDFGL.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl este...; IEA:HAMAP.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:HAMAP.
DR   HAMAP; MF_01840; -; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Complete proteome; Iron; Metal-binding;
KW   NADP; Oxidoreductase; Photosynthesis.
FT   CHAIN         1    360       Magnesium-protoporphyrin IX monomethyl
FT                                ester [oxidative] cyclase.
FT                                /FTId=PRO_1000070555.
SQ   SEQUENCE   360 AA;  41655 MW;  5A83AB79A6A043B3 CRC64;
     MPPTAVTEAT AVPGSNVTTK DPAKDTILTP RFYTTDFEAM AAMDLRPNEA ELEAICEEFR
     KDYNRHHFVR NGEFDGAADQ LDPETRKVFV EFLEQSCTSE FSGFLLYKEL SRRIKTKNPL
     LAECFSHMAR DEARHAGFLN KSMSDFGLQL DLGFLTSSKS YTFFKPKFIF YATYLSEKIG
     YWRYITIFRH LEQNPDSKIF PIFNFFENWC QDENRHGDFF DALMKAQPET VRGLRARLWC
     RFFLLAVFAT MYVRDVARKE FYEALGLDAR EYDRLVIDKT NENTARVFPV VLDVKNPRFY
     NGLERLVNNN AALSAVDATQ APAPIKLLRK LPHWVANGAQ MASLFLMAPI RSDRYHPSVR
//