Q0IAL0 (ACSF_SYNS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81

Gene names

Name:	acsF
Ordered Locus Names:	sync_1304

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP]

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840
Cofactor	Iron By similarity. HAMAP MF_01840
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840
Sequence similarities	Belongs to the AcsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840		PRO_1000070555

Sequences

	Sequence		Length	Mass (Da)
	Q0IAL0 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 5A83AB79A6A043B3	FASTA	360	41,655
	10 20 30 40 50 60 MPPTAVTEAT AVPGSNVTTK DPAKDTILTP RFYTTDFEAM AAMDLRPNEA ELEAICEEFR 70 80 90 100 110 120 KDYNRHHFVR NGEFDGAADQ LDPETRKVFV EFLEQSCTSE FSGFLLYKEL SRRIKTKNPL 130 140 150 160 170 180 LAECFSHMAR DEARHAGFLN KSMSDFGLQL DLGFLTSSKS YTFFKPKFIF YATYLSEKIG 190 200 210 220 230 240 YWRYITIFRH LEQNPDSKIF PIFNFFENWC QDENRHGDFF DALMKAQPET VRGLRARLWC 250 260 270 280 290 300 RFFLLAVFAT MYVRDVARKE FYEALGLDAR EYDRLVIDKT NENTARVFPV VLDVKNPRFY 310 320 330 340 350 360 NGLERLVNNN AALSAVDATQ APAPIKLLRK LPHWVANGAQ MASLFLMAPI RSDRYHPSVR

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9311.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI47230.1.
RefSeq	YP_730512.1. NC_008319.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0IAL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4260235.
GenomeReviews	Gene locus sync_1304 in contig CP000435_GR.
KEGG	syg:sync_1304.
PATRIC	23793618. VBISynSp88089_1368.
TIGR	sync_1304.
Phylogenomic databases
eggNOG	NOG10633.
HOGENOM	HBG284843.
OMA	HGDFFDA.
PhylomeDB	Q0IAL0.
ProtClustDB	PRK13654.
Family and domain databases
HAMAP	MF_01840. AcsF. [Tree]
InterPro	IPR008434. AcsF. IPR012347. Ferritin-rel. IPR009078. Ferritin/RR-like. IPR003251. Rubrerythrin. [Graphical view]
Gene3D	G3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KO	K04035.
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF_SYNS3

Accession

Primary (citable) accession number: Q0IAL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program