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Q0IAE0

- SYL_SYNS3

UniProt

Q0IAE0 - SYL_SYNS3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei634 – 6341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP64471:GIVP-1375-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:sync_1375
    OrganismiSynechococcus sp. (strain CC9311)
    Taxonomic identifieri64471 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001961: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Leucine--tRNA ligasePRO_0000334828Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi64471.sync_1375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IAE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi57 – 6711"HIGH" regionAdd
    BLAST
    Motifi631 – 6355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0IAE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAFSSPSSN AASSATDRYQ PLALEERWQA LWKEQRLYET QDPKPGQRAF    50
    YALSMFPYPS GTLHMGHVRN YVITDVIARV QRMRGDAVLH PMGWDAFGLP 100
    AENAAIERKI EPGVWTDSNI AQMRGQLGRL GLSIDWDREV ATCHSDYYRW 150
    TQWLFLELHA GGLAYQKDAT VNWDPVDQTV LANEQVDADG RSWRSGALVE 200
    KRDLRQWFLR ITDYADALLD DLDQLQGWPE RVRTMQANWI GRSIGAEIDF 250
    QVEAHPGTSI TVFTTRPDTL FGVSYLVLAP DHALVDQLTT SEERISVTAF 300
    RDLMAELSQD ERTSDDQPKR GVPTGAVAIN PANGKSIPIW IADYVLADYG 350
    TGAVMGVPAH DVRDFSFARQ HELPVQRVIE VSGTNEHVND GEAWAGPGTL 400
    IHSAGFSGLS NDEAKTAITN HGAENGWARA KRQYRLRDWL ISRQRYWGCP 450
    IPIIHCDDCG AVPVPRDQLP VELPTGIDLK GAGGSPLARA EDWVSVTCPK 500
    CGKPARRETD TMDTFMCSSW YYLRFADPHN RDLPFNATSV NRWLPVKQYV 550
    GGIEHAILHL LYARFFTKAL NDRDLLQTKE PFERLLTQGM VQGTTYRNPR 600
    TGRYISPAAV KDESNPLDPD DGGPLEVLFE KMSKSKHNGV DPAAVIDRYG 650
    ADTARMFILF KAPPEKDLEW DDADVEGQFR FLQRLWRLVD SEVNHDGVSP 700
    ATGESDSDIR RAVHQAIKAV SEDLSDDFQF NTAISELMKL SNSLSSGLAQ 750
    ASPGVRQEAM SALVRLLAPF APHLAEEFWQ RLGGEDSVHC QPWPDHDPEA 800
    LVLASIEVVI QVKGKVRGSM SVAADCSKEE LERLALASDV AQRWLEGKPP 850
    RRVIVVPGKL VNLVPSS 867
    Length:867
    Mass (Da):96,742
    Last modified:October 3, 2006 - v1
    Checksum:i88FE65741507DAF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI47465.1.
    RefSeqiWP_011619300.1. NC_008319.1.
    YP_730582.1. NC_008319.1.

    Genome annotation databases

    EnsemblBacteriaiABI47465; ABI47465; sync_1375.
    GeneIDi4259924.
    KEGGisyg:sync_1375.
    PATRICi23793760. VBISynSp88089_1438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI47465.1 .
    RefSeqi WP_011619300.1. NC_008319.1.
    YP_730582.1. NC_008319.1.

    3D structure databases

    ProteinModelPortali Q0IAE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64471.sync_1375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI47465 ; ABI47465 ; sync_1375 .
    GeneIDi 4259924.
    KEGGi syg:sync_1375.
    PATRICi 23793760. VBISynSp88089_1438.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSP64471:GIVP-1375-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9311.

    Entry informationi

    Entry nameiSYL_SYNS3
    AccessioniPrimary (citable) accession number: Q0IAE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3