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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP64471:GIVP-1375-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:sync_1375
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Leucine--tRNA ligasePRO_0000334828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_1375.

Structurei

3D structure databases

ProteinModelPortaliQ0IAE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 6711"HIGH" regionAdd
BLAST
Motifi631 – 6355"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0IAE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAFSSPSSN AASSATDRYQ PLALEERWQA LWKEQRLYET QDPKPGQRAF
60 70 80 90 100
YALSMFPYPS GTLHMGHVRN YVITDVIARV QRMRGDAVLH PMGWDAFGLP
110 120 130 140 150
AENAAIERKI EPGVWTDSNI AQMRGQLGRL GLSIDWDREV ATCHSDYYRW
160 170 180 190 200
TQWLFLELHA GGLAYQKDAT VNWDPVDQTV LANEQVDADG RSWRSGALVE
210 220 230 240 250
KRDLRQWFLR ITDYADALLD DLDQLQGWPE RVRTMQANWI GRSIGAEIDF
260 270 280 290 300
QVEAHPGTSI TVFTTRPDTL FGVSYLVLAP DHALVDQLTT SEERISVTAF
310 320 330 340 350
RDLMAELSQD ERTSDDQPKR GVPTGAVAIN PANGKSIPIW IADYVLADYG
360 370 380 390 400
TGAVMGVPAH DVRDFSFARQ HELPVQRVIE VSGTNEHVND GEAWAGPGTL
410 420 430 440 450
IHSAGFSGLS NDEAKTAITN HGAENGWARA KRQYRLRDWL ISRQRYWGCP
460 470 480 490 500
IPIIHCDDCG AVPVPRDQLP VELPTGIDLK GAGGSPLARA EDWVSVTCPK
510 520 530 540 550
CGKPARRETD TMDTFMCSSW YYLRFADPHN RDLPFNATSV NRWLPVKQYV
560 570 580 590 600
GGIEHAILHL LYARFFTKAL NDRDLLQTKE PFERLLTQGM VQGTTYRNPR
610 620 630 640 650
TGRYISPAAV KDESNPLDPD DGGPLEVLFE KMSKSKHNGV DPAAVIDRYG
660 670 680 690 700
ADTARMFILF KAPPEKDLEW DDADVEGQFR FLQRLWRLVD SEVNHDGVSP
710 720 730 740 750
ATGESDSDIR RAVHQAIKAV SEDLSDDFQF NTAISELMKL SNSLSSGLAQ
760 770 780 790 800
ASPGVRQEAM SALVRLLAPF APHLAEEFWQ RLGGEDSVHC QPWPDHDPEA
810 820 830 840 850
LVLASIEVVI QVKGKVRGSM SVAADCSKEE LERLALASDV AQRWLEGKPP
860
RRVIVVPGKL VNLVPSS
Length:867
Mass (Da):96,742
Last modified:October 3, 2006 - v1
Checksum:i88FE65741507DAF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI47465.1.
RefSeqiWP_011619300.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI47465; ABI47465; sync_1375.
KEGGisyg:sync_1375.
PATRICi23793760. VBISynSp88089_1438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI47465.1.
RefSeqiWP_011619300.1. NC_008319.1.

3D structure databases

ProteinModelPortaliQ0IAE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64471.sync_1375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI47465; ABI47465; sync_1375.
KEGGisyg:sync_1375.
PATRICi23793760. VBISynSp88089_1438.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciSSP64471:GIVP-1375-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiSYL_SYNS3
AccessioniPrimary (citable) accession number: Q0IAE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 3, 2006
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.