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Q0IAE0 (SYL_SYNS3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:sync_1375
OrganismSynechococcus sp. (strain CC9311) [Complete proteome] [HAMAP]
Taxonomic identifier64471 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length867 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 867867Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334828

Regions

Motif57 – 6711"HIGH" region HAMAP-Rule MF_00049
Motif631 – 6355"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0IAE0 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 88FE65741507DAF4

FASTA86796,742
        10         20         30         40         50         60 
MTAFSSPSSN AASSATDRYQ PLALEERWQA LWKEQRLYET QDPKPGQRAF YALSMFPYPS 

        70         80         90        100        110        120 
GTLHMGHVRN YVITDVIARV QRMRGDAVLH PMGWDAFGLP AENAAIERKI EPGVWTDSNI 

       130        140        150        160        170        180 
AQMRGQLGRL GLSIDWDREV ATCHSDYYRW TQWLFLELHA GGLAYQKDAT VNWDPVDQTV 

       190        200        210        220        230        240 
LANEQVDADG RSWRSGALVE KRDLRQWFLR ITDYADALLD DLDQLQGWPE RVRTMQANWI 

       250        260        270        280        290        300 
GRSIGAEIDF QVEAHPGTSI TVFTTRPDTL FGVSYLVLAP DHALVDQLTT SEERISVTAF 

       310        320        330        340        350        360 
RDLMAELSQD ERTSDDQPKR GVPTGAVAIN PANGKSIPIW IADYVLADYG TGAVMGVPAH 

       370        380        390        400        410        420 
DVRDFSFARQ HELPVQRVIE VSGTNEHVND GEAWAGPGTL IHSAGFSGLS NDEAKTAITN 

       430        440        450        460        470        480 
HGAENGWARA KRQYRLRDWL ISRQRYWGCP IPIIHCDDCG AVPVPRDQLP VELPTGIDLK 

       490        500        510        520        530        540 
GAGGSPLARA EDWVSVTCPK CGKPARRETD TMDTFMCSSW YYLRFADPHN RDLPFNATSV 

       550        560        570        580        590        600 
NRWLPVKQYV GGIEHAILHL LYARFFTKAL NDRDLLQTKE PFERLLTQGM VQGTTYRNPR 

       610        620        630        640        650        660 
TGRYISPAAV KDESNPLDPD DGGPLEVLFE KMSKSKHNGV DPAAVIDRYG ADTARMFILF 

       670        680        690        700        710        720 
KAPPEKDLEW DDADVEGQFR FLQRLWRLVD SEVNHDGVSP ATGESDSDIR RAVHQAIKAV 

       730        740        750        760        770        780 
SEDLSDDFQF NTAISELMKL SNSLSSGLAQ ASPGVRQEAM SALVRLLAPF APHLAEEFWQ 

       790        800        810        820        830        840 
RLGGEDSVHC QPWPDHDPEA LVLASIEVVI QVKGKVRGSM SVAADCSKEE LERLALASDV 

       850        860 
AQRWLEGKPP RRVIVVPGKL VNLVPSS 

« Hide

References

[1]"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment."
Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T.
Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CC9311.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000435 Genomic DNA. Translation: ABI47465.1.
RefSeqYP_730582.1. NC_008319.1.

3D structure databases

ProteinModelPortalQ0IAE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64471.sync_1375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI47465; ABI47465; sync_1375.
GeneID4259924.
KEGGsyg:sync_1375.
PATRIC23793760. VBISynSp88089_1438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycSSP64471:GIVP-1375-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNS3
AccessionPrimary (citable) accession number: Q0IAE0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries