Q0I9W4 (Q0I9W4_SYNS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	sync_1553

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP] EMBL ABI47486.1

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABI47486.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	531	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	623	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q0I9W4 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 815162A1981AD7BB	FASTA	656	71,824
	10 20 30 40 50 60 MSEGSTIESV LQEQRVFDPP ADLARDARIS GMDSYRALAE AAKSDPDTFW GDAARRELHW 70 80 90 100 110 120 FEPFHTVLDW DNPPFARWFE GGTTNLSYNC LDRHLNGPKA SKTALIWEGE PGDVRTFTYQ 130 140 150 160 170 180 ELHAEVCRAA NALKAIGIGK GDLVALYMPM VPEAAIAMLA CARIGAPHSV VFGGFSAEAL 190 200 210 220 230 240 RDRLIDGEVK AVITADGGFR KDKPVSLKPA VNAALANSAC PTVKSVLVVK RTDQPVEMVD 250 260 270 280 290 300 GRDQWWHELV AHQSDECTAE PMASEDRLFV LYTSGSTGKP KGVVHTTAGY NLWTHLTFQW 310 320 330 340 350 360 IFDIRDDDVF WCTADVGWIT GHSYIVYGPL SNGATTVMYE GAPRPSKPGA FWELIQKHRV 370 380 390 400 410 420 SIFYTAPTAI RAFMRSGRAV PDQYDMSSLR LLGTVGEPIN PEAWMWYRDV VGGERCPIVD 430 440 450 460 470 480 TWWQTETGGV MISPLPGATP TKPGSATLPL PGIQADIIDA EGNSCGANEG GYLAVRAPWP 490 500 510 520 530 540 GMMRTVHGNP QRFRESYWEA IRPSDGSHLY FAGDGARRDA DGYFWVMGRV DDVINVSGHR 550 560 570 580 590 600 LGTMEIESAL VSHPAVAEAA VVGRPDDLKG EGIVAFVTLE LGRESNDALV AELRTHVGKE 610 620 630 640 650 IGPIARPDEI RCSDALPKTR SGKIMRRILR ALAAGEEVTG DTSTLEDRSV LDRLRG

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI47486.1.
RefSeq	YP_730758.1. NC_008319.1.
3D structure databases
ProteinModelPortal	Q0I9W4.
SMR	Q0I9W4. Positions 19-655.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I9W4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4259867.
GenomeReviews	Gene locus sync_1553 in contig CP000435_GR.
KEGG	syg:sync_1553.
PATRIC	23794136. VBISynSp88089_1625.
TIGR	sync_1553.
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	VISVSGH.
PhylomeDB	Q0I9W4.
ProtClustDB	CLSK919509.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0I9W4_SYNS3

Accession

Primary (citable) accession number: Q0I9W4

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)