Q0I8T6 (DNAA_SYNS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	sync_1933

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP]

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048750
Regions
	Nucleotide binding	169 – 176	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0I8T6 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 7249F69DB5F14B4C	FASTA	468	51,984
	10 20 30 40 50 60 MELTGSELWD KVQHALQSNL SKPTFETWIR PARCSSFQDR MLTLQAPNSF ASNWLRKNYA 70 80 90 100 110 120 STIAEVAQEI IGHPIEVIVL AQDDEDAESG STPLSRVSTS NQPLASTAAE AAAAVSAPPS 130 140 150 160 170 180 TAPRRLPGLN MRYVFNRFVV GPNSRMAHAA ALAVAEAPGR EFNPLFICGG VGLGKTHLMQ 190 200 210 220 230 240 AIGHYRLEID PEARVFYVST ETFTNDLITA IRKDGMQAFR DRYRAADLIL VDDIQFIEGK 250 260 270 280 290 300 EYTQEEFFHT FNALHDAGRQ IVIASDRPPS QIPRLQERLI SRFSMGLIAD IQAPDLETRM 310 320 330 340 350 360 AILQKKAEQE RVALPRDLIQ YISGRFTSNI RELEGALTRA VAFSSITGIP MTVESVAPML 370 380 390 400 410 420 DPSGQGVDVT PQQVIEKVSE VFDVTADDMR SSSRRRAVSQ ARQVGMFLMR QGTDLSLPRI 430 440 450 460 GDTFGGKDHT TVIYAIEQVE KKLATDPQLA SQVQRVKDLL QIDSRRRR

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9311.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI46141.1.
RefSeq	YP_731136.1. NC_008319.1.
3D structure databases
ProteinModelPortal	Q0I8T6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I8T6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4260870.
GenomeReviews	Gene locus sync_1933 in contig CP000435_GR.
KEGG	syg:sync_1933.
PATRIC	23794934. VBISynSp88089_2022.
TIGR	sync_1933.
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q0I8T6.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SYNS3

Accession

Primary (citable) accession number: Q0I8T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program