Q0I8N1 (ACCA_SYNS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Short name=ACCase subunit alpha
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha
EC=6.4.1.2

Gene names

Name:	accA
Ordered Locus Names:	sync_1988

Organism

Synechococcus sp. (strain CC9311) [Complete proteome] [HAMAP]

Taxonomic identifier

64471 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823
Catalytic activity	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823
Subunit structure	Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00823.
Sequence similarities	Belongs to the AccA family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	acetyl-CoA carboxylase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823		PRO_1000062691

Sequences

	Sequence		Length	Mass (Da)
	Q0I8N1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 9BE4EDEFC543F1FA	FASTA	329	36,197
	10 20 30 40 50 60 MARRPLLEFE KPLIELEQQI EQIRQLARDS EVDVSQQLLQ LETLAARRRE EIFQNLTPAQ 70 80 90 100 110 120 KIQVARHPHR PSTLDFIQMF CDDWVELHGD RRGSDDQALV GGLGRIGDRS VVLLGHQKGR 130 140 150 160 170 180 DTKENVARNF GMATPGGYRK ALRLMEHADR FGLPIFAFID TPGAYAGLLA EEQGQGEAIA 190 200 210 220 230 240 VNLREMFRLR VPIIATVIGE GGSGGALGIG VADRLLMFEH SVYTVASPEA CASILWRDAA 250 260 270 280 290 300 KAPEAAAALR ITGKDLLSLG VVDEVLAEPS GGNNWAPLEA GATLREALER NLSELLALPP 310 320 QELRDQRYRK FRAMGRFIDQ ASSDADSAS

References

[1]

"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment." Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9311.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000435 Genomic DNA. Translation: ABI45895.1.
RefSeq	YP_731191.1. NC_008319.1.
3D structure databases
ProteinModelPortal	Q0I8N1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I8N1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4260858.
GenomeReviews	Gene locus sync_1988 in contig CP000435_GR.
KEGG	syg:sync_1988.
PATRIC	23795044. VBISynSp88089_2077.
TIGR	sync_1988.
Phylogenomic databases
eggNOG	COG0825.
HOGENOM	HBG286557.
OMA	GRDTKDN.
PhylomeDB	Q0I8N1.
ProtClustDB	PRK05724.
Family and domain databases
HAMAP	MF_00823. AcetylCoA_CT_alpha. [Tree]
InterPro	IPR001095. Acetyl_CoA_COase_a_su. IPR011763. COA_CT_C. [Graphical view]
KO	K01962.
PANTHER	PTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
Pfam	PF03255. ACCA. 1 hit. [Graphical view]
PRINTS	PR01069. ACCCTRFRASEA.
TIGRFAMs	TIGR00513. AccA. 1 hit.
PROSITE	PS50989. COA_CT_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCA_SYNS3

Accession

Primary (citable) accession number: Q0I8N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program