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Q0I8L9 (HEMH_SYNS3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:sync_2000
OrganismSynechococcus sp. (strain CC9311) [Complete proteome] [HAMAP]
Taxonomic identifier64471 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Ferrochelatase HAMAP MF_00323
PRO_1000019380

Sites

Metal binding1961Iron By similarity
Metal binding2811Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0I8L9 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: E64ACDF33BB5EB76

FASTA39143,932
        10         20         30         40         50         60 
MARVGILLLN LGGPERIQDV GPFLYNLFAD PEIIRLPNPI LQKPLAWLIS TLRSSKSQEA 

        70         80         90        100        110        120 
YRSIGGGSPL RRITEQQARE LQSLLRQRGV DATSYVAMRY WHPFTESAVA DIKADGIDEV 

       130        140        150        160        170        180 
VVLPLYPHFS ISTSGSSFRE LQRLRQMDER FEALPLRCIR SWYDHPGYVR SMAELIAEQV 

       190        200        210        220        230        240 
RASDDVEHAH IFFSAHGVPK SYVEEAGDPY QQEIEACAAL IMAELETIVG HSNPHTLAYQ 

       250        260        270        280        290        300 
SRVGPVEWLK PYTEEALEEL GRAKTQDLVV VPISFVSEHI ETLEEIDIEY RELATESGVV 

       310        320        330        340        350        360 
NFRRVRALDT YPPFISGLAD LVVASLEGPE VNLDQAAELP TTVKLYPQEK WEWGWNNSSE 

       370        380        390 
VWNGRLAMIG FSAFLLELIS GHGPLHAVGL L

« Hide

References

[1]"Genome sequence of Synechococcus CC9311: insights into adaptation to a coastal environment."
Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H., Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S., Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R., Paulsen I.T.
Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006) [PubMed: 16938853] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CC9311.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000435 Genomic DNA. Translation: ABI46184.1.
RefSeqYP_731203.1. NC_008319.1.

3D structure databases

ProteinModelPortalQ0I8L9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0I8L9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4261128.
GenomeReviewsGene locus sync_2000 in contig CP000435_GR.
KEGGsyg:sync_2000.
PATRIC23795068. VBISynSp88089_2089.
TIGRsync_2000.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ0I8L9.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNS3
AccessionPrimary (citable) accession number: Q0I8L9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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