Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease Z

Gene

rnz

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Active sitei66Proton acceptorUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi144Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 1; catalyticUniRule annotation1
Metal bindingi215Zinc 2; catalyticUniRule annotation1
Metal bindingi273Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:sync_2249
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001961 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000703461 – 315Ribonuclease ZAdd BLAST315

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi64471.sync_2249.

Structurei

3D structure databases

ProteinModelPortaliQ0I7X5.
SMRiQ0I7X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG091H07TH.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF12706. Lactamase_B_2. 2 hits.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I7X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTFLGTSS GVPTRGRNVS SVALRLPQRS ELWLFDCGEG TQHQFLRCDL
60 70 80 90 100
RLSQLRRVFI THMHGDHVFG LPGLLASLGL GSTSNGVDLY GPDPLDAYLQ
110 120 130 140 150
GVLRTSSTRI GYPLAIHRVR EAAEQNTVVF EDDDLIVTAA PLNHRVPAYA
160 170 180 190 200
YRAEQKPRAG RFDIDKAREL QIPPGPVYAA LKRGESVTLD DGRTIDGRTL
210 220 230 240 250
CGPEQPGVSV VYCTDTVFCE AAVQLAQGAD LLIHESTFSH AEADMAFKRQ
260 270 280 290 300
HSTSTMAAQT AAEAGVKQLA LTHLSPRYAP GNAVTADDLV AEASAIFPNT
310
ILARDFLNVD VNPSK
Length:315
Mass (Da):34,137
Last modified:October 3, 2006 - v1
Checksum:i510C7182D17C44F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI47549.1.
RefSeqiWP_011620159.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI47549; ABI47549; sync_2249.
KEGGisyg:sync_2249.

Similar proteinsi

Entry informationi

Entry nameiRNZ_SYNS3
AccessioniPrimary (citable) accession number: Q0I7X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 3, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families