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Q0I7A5

- DEF_SYNS3

UniProt

Q0I7A5 - DEF_SYNS3

Protein

Peptide deformylase

Gene

def

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi121 – 1211IronUniRule annotation
    Metal bindingi163 – 1631IronUniRule annotation
    Active sitei164 – 1641UniRule annotation
    Metal bindingi167 – 1671IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSSP64471:GIVP-2473-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:sync_2473
    OrganismiSynechococcus sp. (strain CC9311)
    Taxonomic identifieri64471 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001961: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Peptide deformylasePRO_0000301115Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi64471.sync_2473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0I7A5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiDMYDTMD.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0I7A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSFAQLAR SAEKSSSSIA VPKEPLETAP LDIHTLGDDA LRGDARRIGK    50
    VDERVRDLAR DMLRSMYTAS GIGLAAPQVG VHQQLLVIDL DFETPSTPPL 100
    VLINPEITTC SASVDTYEEG CLSIPGVYLD VVRPTAIQLS FRDEMGRPRT 150
    MKADGLMARC IQHEMDHLRG VLFVDRVTDA GGLKKELKDH GFLATDVRPI 200
    TP 202
    Length:202
    Mass (Da):22,092
    Last modified:October 3, 2006 - v1
    Checksum:i8E325C1489CC7591
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI47601.1.
    RefSeqiWP_011620375.1. NC_008319.1.
    YP_731667.1. NC_008319.1.

    Genome annotation databases

    EnsemblBacteriaiABI47601; ABI47601; sync_2473.
    GeneIDi4259748.
    KEGGisyg:sync_2473.
    PATRICi23796048. VBISynSp88089_2571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI47601.1 .
    RefSeqi WP_011620375.1. NC_008319.1.
    YP_731667.1. NC_008319.1.

    3D structure databases

    ProteinModelPortali Q0I7A5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64471.sync_2473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI47601 ; ABI47601 ; sync_2473 .
    GeneIDi 4259748.
    KEGGi syg:sync_2473.
    PATRICi 23796048. VBISynSp88089_2571.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi DMYDTMD.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci SSP64471:GIVP-2473-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9311.

    Entry informationi

    Entry nameiDEF_SYNS3
    AccessioniPrimary (citable) accession number: Q0I7A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3