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Q0I740

- UPPP_SYNS3

UniProt

Q0I740 - UPPP_SYNS3

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, sync_2543
Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSSP64471:GIVP-2543-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:sync_2543
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001961: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11421Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Undecaprenyl-diphosphataseUniRule annotation
PRO_0000290775Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_2543.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I740-1 [UniParc]FASTAAdd to Basket

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MTPDPGLLEA CWRDFVLGVV QGLTEFLPIS STAHLKVVPV LAGWGDPGLS    50
VTAVIQLGSI VAVIAYFRAD LAGVLKGISG AFRRGQWREP EARLGIAMLI 100
GTLPILIAGL CIKLYWPGYA TSSLRSVPAI AVVSIVMALL LGFAELLGPR 150
LKQLNQVDGR DGLVVGLAQV FSLIPGVSRS GSTLTASLFD GWKRADAARF 200
SFLLGIPAIT IAGLVELKDA FSGSSAGGVL PVFVGICSAA VVSWLAIDWL 250
IKYLESHSTR IFVVYRLLFG VLLLVWWSGS ASN 283
Length:283
Mass (Da):29,990
Last modified:October 3, 2006 - v1
Checksum:i1227E620A4A94957
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI46329.1.
RefSeqiWP_011620437.1. NC_008319.1.
YP_731732.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI46329; ABI46329; sync_2543.
GeneIDi4259705.
KEGGisyg:sync_2543.
PATRICi23796200. VBISynSp88089_2642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000435 Genomic DNA. Translation: ABI46329.1 .
RefSeqi WP_011620437.1. NC_008319.1.
YP_731732.1. NC_008319.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 64471.sync_2543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI46329 ; ABI46329 ; sync_2543 .
GeneIDi 4259705.
KEGGi syg:sync_2543.
PATRICi 23796200. VBISynSp88089_2642.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SSP64471:GIVP-2543-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9311.

Entry informationi

Entry nameiUPPP_SYNS3
AccessioniPrimary (citable) accession number: Q0I740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi