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Q0I740

- UPPP_SYNS3

UniProt

Q0I740 - UPPP_SYNS3

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSP64471:GIVP-2543-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:sync_2543
    OrganismiSynechococcus sp. (strain CC9311)
    Taxonomic identifieri64471 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001961: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Undecaprenyl-diphosphatasePRO_0000290775Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi64471.sync_2543.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei197 – 21721HelicalUniRule annotationAdd
    BLAST
    Transmembranei227 – 24721HelicalUniRule annotationAdd
    BLAST
    Transmembranei261 – 28121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0I740-1 [UniParc]FASTAAdd to Basket

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    MTPDPGLLEA CWRDFVLGVV QGLTEFLPIS STAHLKVVPV LAGWGDPGLS    50
    VTAVIQLGSI VAVIAYFRAD LAGVLKGISG AFRRGQWREP EARLGIAMLI 100
    GTLPILIAGL CIKLYWPGYA TSSLRSVPAI AVVSIVMALL LGFAELLGPR 150
    LKQLNQVDGR DGLVVGLAQV FSLIPGVSRS GSTLTASLFD GWKRADAARF 200
    SFLLGIPAIT IAGLVELKDA FSGSSAGGVL PVFVGICSAA VVSWLAIDWL 250
    IKYLESHSTR IFVVYRLLFG VLLLVWWSGS ASN 283
    Length:283
    Mass (Da):29,990
    Last modified:October 3, 2006 - v1
    Checksum:i1227E620A4A94957
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI46329.1.
    RefSeqiWP_011620437.1. NC_008319.1.
    YP_731732.1. NC_008319.1.

    Genome annotation databases

    EnsemblBacteriaiABI46329; ABI46329; sync_2543.
    GeneIDi4259705.
    KEGGisyg:sync_2543.
    PATRICi23796200. VBISynSp88089_2642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000435 Genomic DNA. Translation: ABI46329.1 .
    RefSeqi WP_011620437.1. NC_008319.1.
    YP_731732.1. NC_008319.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64471.sync_2543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI46329 ; ABI46329 ; sync_2543 .
    GeneIDi 4259705.
    KEGGi syg:sync_2543.
    PATRICi 23796200. VBISynSp88089_2642.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SSP64471:GIVP-2543-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9311.

    Entry informationi

    Entry nameiUPPP_SYNS3
    AccessioniPrimary (citable) accession number: Q0I740
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3