Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidylate kinase

Gene

tmk

Organism
Synechococcus sp. (strain CC9311)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:sync_2593
OrganismiSynechococcus sp. (strain CC9311)
Taxonomic identifieri64471 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001961 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000233021 – 212Thymidylate kinaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi64471.sync_2593.

Structurei

3D structure databases

ProteinModelPortaliQ0I6Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiPOG091H02B9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0I6Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLLVLEGI DGCGKTTQLQ QLSSWLPKSG LMPDESRLVV TREPGGTALG
60 70 80 90 100
TSLRQLLLHP PQDADPGPTA ELLLYAADRA QHVDRVIQPA LERGDWVLSD
110 120 130 140 150
RFTGSTMAYQ GYGRGLNREL ITDLERIATR GLTPDMTVWL DIPLALSVQR
160 170 180 190 200
RGSREEDRIE AEGLAFLERV SEGFSDMCKA RDWVSVVADR PLLEVAEAIQ
210
TALLTRAAAW QR
Length:212
Mass (Da):23,434
Last modified:October 3, 2006 - v1
Checksum:i31024C6077A83633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI47598.1.
RefSeqiWP_011620485.1. NC_008319.1.

Genome annotation databases

EnsemblBacteriaiABI47598; ABI47598; sync_2593.
KEGGisyg:sync_2593.
PATRICi23796300. VBISynSp88089_2691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000435 Genomic DNA. Translation: ABI47598.1.
RefSeqiWP_011620485.1. NC_008319.1.

3D structure databases

ProteinModelPortaliQ0I6Z1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64471.sync_2593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI47598; ABI47598; sync_2593.
KEGGisyg:sync_2593.
PATRICi23796300. VBISynSp88089_2691.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiPOG091H02B9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_SYNS3
AccessioniPrimary (citable) accession number: Q0I6Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.