Q0I5V1 (SDHD_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable D-serine dehydratase
EC=4.3.1.18

Alternative name(s):
D-serine deaminase
Short name=DSD

Gene names

Name:	dsdA
Ordered Locus Names:	HS_1718

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP MF_01030
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01030
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Sequence caution	The sequence ABI25986.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Probable D-serine dehydratase HAMAP MF_01030		PRO_0000291732
Amino acid modifications
	Modified residue	114	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0I5V1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: DEB359375D95687C	FASTA	438	48,558
	10 20 30 40 50 60 MKIQHLMQDP FIQKLMRFEE VMWFNPKSAG VKTGLSYVGL DVSDTQQAAE RLQRFAPYFC 70 80 90 100 110 120 RAFPETQKTK GILESELVSI DKMKSALIDH YHMPIQGRLL LKKDSHLPIS GSIKARGGIY 130 140 150 160 170 180 EVLAYAEKLA LEHHLITEND DYSQLCDEKI KDFFSRYSIA VGSTGNLGLS IGIMGAVLGF 190 200 210 220 230 240 KVSVHMSADA REWKKQKLRS YGVNVVEYTQ DYGVAVAQGR KAALSDPNCF FIDDENSTTL 250 260 270 280 290 300 FLGYSVAGQR LKQQFLEQGI KVDENHPLFV YLPCGVGGGP GGVAFGLKLA FGDYVHCIFA 310 320 330 340 350 360 EPTHSPCMLL GVYTGLHDKI AVQDLGIDNI TAADGLAVGR ASGFVGRAME HLLDGFYTIE 370 380 390 400 410 420 DQKLYDLLGL LHKTENIQLE PSALAGMIGP LHINHSDYLR RYHITQEQLA NATHIVWATG 430 GGMVPDVEMQ KYLSLGRF

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25986.1. Different initiation.
RefSeq	YP_719923.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I5V1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I5V1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4241250.
GenomeReviews	Gene locus HS_1718 in contig CP000436_GR.
KEGG	hso:HS_1718.
NMPDR	fig|205914.1.peg.1659.
PATRIC	20283605. VBIHaeSom53361_1797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3048.
HOGENOM	HBG288722.
ProtClustDB	PRK02991.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1718-MONOMER.
Family and domain databases
HAMAP	MF_01030. D-Ser_dehydrat. [Tree]
InterPro	IPR011780. D_Ser_am_lyase. IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
KO	K01753.
PANTHER	PTHR10314:SF9. D_Ser_am_lyase. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD_HAES1

Accession

Primary (citable) accession number: Q0I5V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program