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Q0I5L8

- KGUA_HISS1

UniProt

Q0I5L8 - KGUA_HISS1

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Protein

Guanylate kinase

Gene
gmk, HS_1457
Organism
Histophilus somni (strain 129Pt) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:HS_1457
OrganismiHistophilus somni (strain 129Pt) (Haemophilus somnus)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000001970: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Guanylate kinaseUniRule annotationPRO_0000266333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_1457.

Structurei

3D structure databases

ProteinModelPortaliQ0I5L8.
SMRiQ0I5L8. Positions 3-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 185182Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0I5L8-1 [UniParc]FASTAAdd to Basket

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MCRGNLYIIS APSGAGKSSL ISALLERDKN DSMTVSISHT TRSPRPGEID    50
GVHYHFVSHE KFEQLILENS FLEYAKVFGG NYYGTSLLNI EKNLAAGIDV 100
FLDIDWQGAR QIREKRPDVK SIFILPPSIS ALEKRLIGRG QDSQDIIAKR 150
MEKAADEISH YDEYDYVIIN ADFDQALVDL EHILRAERLT VNYQKTQNAA 200
LIHQLLVK 208
Length:208
Mass (Da):23,522
Last modified:December 12, 2006 - v2
Checksum:iA2030A98ED3CBEFC
GO

Sequence cautioni

The sequence ABI25732.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25732.1. Different initiation.
RefSeqiYP_719669.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25732; ABI25732; HS_1457.
GeneIDi4240978.
KEGGihso:HS_1457.
PATRICi20283043. VBIHaeSom53361_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000436 Genomic DNA. Translation: ABI25732.1 . Different initiation.
RefSeqi YP_719669.1. NC_008309.1.

3D structure databases

ProteinModelPortali Q0I5L8.
SMRi Q0I5L8. Positions 3-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205914.HS_1457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI25732 ; ABI25732 ; HS_1457 .
GeneIDi 4240978.
KEGGi hso:HS_1457.
PATRICi 20283043. VBIHaeSom53361_1532.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
KOi K00942.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci HSOM205914:GJ7V-1525-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129Pt.

Entry informationi

Entry nameiKGUA_HISS1
AccessioniPrimary (citable) accession number: Q0I5L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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