ID   APAH_HAES1              Reviewed;         273 AA.
AC   Q0I5C4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=HS_1558;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000436; ABI25826.1; -; Genomic_DNA.
DR   RefSeq; YP_719763.1; -.
DR   GeneID; 4241079; -.
DR   GenomeReviews; CP000436_GR; HS_1558.
DR   KEGG; hso:HS_1558; -.
DR   NMPDR; fig|205914.1.peg.1588; -.
DR   HOGENOM; Q0I5C4; -.
DR   OMA; Q0I5C4; LVFGHWA.
DR   BioCyc; HSOM205914:HS_1558-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    273       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012064.
SQ   SEQUENCE   273 AA;  31455 MW;  2FE9D61E68CEC62F CRC64;
     MATYLVGDLQ GCYDELQLLL ETVQFNPVQD KLYLVGDLVA RGDKSLECLR FVKSLGAAAQ
     MVLGNHDLHL ISTALGIKKV SLQDHVEAIF TAPDFVELID WLRHQPLLVH DEKCDFVMSH
     AGISPDWDLD TAKSCAREVE NELQHGDYHY LISNMYDNQP DRWSADLQGL QRLRYSINVF
     TRMRFCYRDH RLDFACKASV EKASQELIPW FNLDNPLFKV QNLVFGHWAS LVDTPTPANI
     YALDTGCVWG NRMTMLRWED KQYFVQGALK DYF
//