Q0I5C4 (APAH_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	HS_1558

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012064

Sequences

	Sequence		Length	Mass (Da)
	Q0I5C4 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 2FE9D61E68CEC62F	FASTA	273	31,455
	10 20 30 40 50 60 MATYLVGDLQ GCYDELQLLL ETVQFNPVQD KLYLVGDLVA RGDKSLECLR FVKSLGAAAQ 70 80 90 100 110 120 MVLGNHDLHL ISTALGIKKV SLQDHVEAIF TAPDFVELID WLRHQPLLVH DEKCDFVMSH 130 140 150 160 170 180 AGISPDWDLD TAKSCAREVE NELQHGDYHY LISNMYDNQP DRWSADLQGL QRLRYSINVF 190 200 210 220 230 240 TRMRFCYRDH RLDFACKASV EKASQELIPW FNLDNPLFKV QNLVFGHWAS LVDTPTPANI 250 260 270 YALDTGCVWG NRMTMLRWED KQYFVQGALK DYF

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25826.1.
RefSeq	YP_719763.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I5C4.
SMR	Q0I5C4. Positions 2-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I5C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4241079.
GenomeReviews	Gene locus HS_1558 in contig CP000436_GR.
KEGG	hso:HS_1558.
NMPDR	fig|205914.1.peg.1588.
PATRIC	20283255. VBIHaeSom53361_1634.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q0I5C4.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1558-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_HAES1

Accession

Primary (citable) accession number: Q0I5C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program