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Protein

Inosose dehydratase

Gene

iolE

Organism
Haemophilus somnus (strain 129Pt) (Histophilus somni)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:HS_1577
OrganismiHaemophilus somnus (strain 129Pt) (Histophilus somni)
Taxonomic identifieri205914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000001970 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Inosose dehydratasePRO_0000352369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205914.HS_1577.

Structurei

3D structure databases

ProteinModelPortaliQ0I5A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OrthoDBiEOG6HB9S9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0I5A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAENVKLGI APIGWTNDDL PEIGKENTFE QCVSEMALAG FTGSEVGSKY
60 70 80 90 100
PRDIDVLKRK LDLRGIQICN AWFSTFFVDG KKEETIKGFI EHRDFLHAMG
110 120 130 140 150
AKVIGCSEQS RSIQGQKKAI FKEKTIFTEA EWQLLAEGYN ELAKLAAEKG
160 170 180 190 200
MKVCLHHHMG TGIQTPAEID KYMEITNDDV YLLFDSGHLY YSEGSQQVML
210 220 230 240 250
EVLEKYIHRV VHVHLKDVRD EVVAEVKAND LSFLEGVVKG TFTVPGDGVI
260 270 280 290
DFKPIFDILE KYDYKGWMVV EAEQDPAIAN PLEYAIKGRQ YIREVAGV
Length:298
Mass (Da):33,630
Last modified:October 3, 2006 - v1
Checksum:iCACFC6B2E4B1314C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI25845.1.
RefSeqiWP_011609723.1. NC_008309.1.

Genome annotation databases

EnsemblBacteriaiABI25845; ABI25845; HS_1577.
KEGGihso:HS_1577.
PATRICi20283309. VBIHaeSom53361_1654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000436 Genomic DNA. Translation: ABI25845.1.
RefSeqiWP_011609723.1. NC_008309.1.

3D structure databases

ProteinModelPortaliQ0I5A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205914.HS_1577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI25845; ABI25845; HS_1577.
KEGGihso:HS_1577.
PATRICi20283309. VBIHaeSom53361_1654.

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OrthoDBiEOG6HB9S9.

Enzyme and pathway databases

BioCyciHSOM205914:GJ7V-1658-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
    Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
    J. Bacteriol. 189:1890-1898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129Pt.

Entry informationi

Entry nameiIOLE_HAES1
AccessioniPrimary (citable) accession number: Q0I5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 3, 2006
Last modified: November 11, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.