Q0I586 (UXUA_HAES1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	HS_1596

Organism

Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]

Taxonomic identifier

205914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase HAMAP MF_00106		PRO_1000034331

Sequences

	Sequence		Length	Mass (Da)
	Q0I586 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 6AB6A2CF850393B6	FASTA	394	44,886
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGQVW SVEEINKRKA LLEEKGLVWS 70 80 90 100 110 120 VVESVPIHED IKTQTGNYQQ WIDNYKQTLR NLASCGIDIV CYNFMPVLDW TRTDLEYEMP 130 140 150 160 170 180 DGSKALRFDQ VAFAAFELYI LKRPGAEETY SPEEQAEAKA YFDQMSEADI AKLTKNIIAG 190 200 210 220 230 240 LPGSEEGYTL EEFQAQLDRY KGISTEKFRT HLAYFLNEIV PVAQEVGIRM AIHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IDDMQWFVDT QPLAANGFTF CTGSYGVLAE NDLVKMAEKF ADRIYFAHLR 310 320 330 340 350 360 STQREENPRS FHEADHLAGD VNMFGVTKAL LTEEYRRKAN GDNRLIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLRGLAEF RGLELALKKV YFND

References

[1]

"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd." Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J. J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129Pt.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000436 Genomic DNA. Translation: ABI25864.1.
RefSeq	YP_719801.1. NC_008309.1.
3D structure databases
ProteinModelPortal	Q0I586.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0I586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4241123.
GenomeReviews	Gene locus HS_1596 in contig CP000436_GR.
KEGG	hso:HS_1596.
NMPDR	fig|205914.1.peg.946.
PATRIC	20283347. VBIHaeSom53361_1673.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
PhylomeDB	Q0I586.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	HSOM205914:HS_1596-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_HAES1

Accession

Primary (citable) accession number: Q0I586

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program