ID   HLDD_HAES1              Reviewed;         309 AA.
AC   Q0I569;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
DE            EC=5.1.3.20;
DE   AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE            Short=ADP-glyceromanno-heptose 6-epimerase;
DE            Short=ADP-hep 6-epimerase;
DE            Short=AGME;
GN   Name=hldD; Synonyms=rfaD; OrderedLocusNames=HS_1613;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17172329; DOI=10.1128/JB.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni)
RT   strain 129Pt and comparison to Haemophilus ducreyi 35000HP and
RT   Haemophilus influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
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DR   EMBL; CP000436; ABI25881.1; -; Genomic_DNA.
DR   RefSeq; YP_719818.1; -.
DR   SMR; Q0I569; 1-306.
DR   GeneID; 4241140; -.
DR   GenomeReviews; CP000436_GR; HS_1613.
DR   KEGG; hso:HS_1613; -.
DR   HOGENOM; Q0I569; -.
DR   OMA; Q0I569; FGPNEYH.
DR   BioCyc; HSOM205914:HS_1613-MON; -.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; -; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; heptose_epim; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   CHAIN         1    309       ADP-L-glycero-D-manno-heptose-6-
FT                                epimerase.
FT                                /FTId=PRO_0000323479.
FT   NP_BIND      10     11       NADP (By similarity).
FT   NP_BIND      31     32       NADP (By similarity).
FT   NP_BIND      75     79       NADP (By similarity).
FT   REGION      200    203       Substrate binding (By similarity).
FT   ACT_SITE    139    139       Proton acceptor (By similarity).
FT   ACT_SITE    177    177       Proton acceptor (By similarity).
FT   BINDING      38     38       NADP (By similarity).
FT   BINDING      53     53       NADP (By similarity).
FT   BINDING      92     92       NADP (By similarity).
FT   BINDING     143    143       NADP (By similarity).
FT   BINDING     168    168       Substrate (By similarity).
FT   BINDING     169    169       NADP; via amide nitrogen (By similarity).
FT   BINDING     177    177       NADP (By similarity).
FT   BINDING     179    179       Substrate; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     186    186       Substrate (By similarity).
FT   BINDING     208    208       Substrate (By similarity).
FT   BINDING     271    271       Substrate (By similarity).
SQ   SEQUENCE   309 AA;  34866 MW;  790866DF9509FF7E CRC64;
     MIIVTGGAGL IGSNIIAALN DMGRRDILVV DNLTDGTKFV NLVDLDIADY CDKEDFIASI
     IAGDDFGDID AIFHQGACSA TTEWNGKYLM QNNYEYSKEL LHYCLLREIP FFYASSAATY
     GDKTDFIEER QFEGPLNVYG YSKFLFDEYV RQILPQATSP VCGFKYFNVY GPREQHKGSM
     ASVAFHLNNQ MLKGENPKLF AGSEHFLRDF VYVGDVAKVN LWAWQHGISG IYNCGTGRAE
     SFEQVARAVL NYHGKGEIET IPFPEHLKSR YQEYTQANLT KLRAAGYQAE FKSVAEGVAE
     YMQWLNRKS
//