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Q0I569 (HLDD_HAES1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP-L-glycero-D-manno-heptose-6-epimerase
EC=5.1.3.20
Alternative name(s):
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Short name=ADP-glyceromanno-heptose 6-epimerase
Short name=ADP-hep 6-epimerase
Short name=AGME
Gene names
Name:hldD
Synonyms:rfaD
Ordered Locus Names:HS_1613
OrganismHaemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) [Complete proteome] [HAMAP]
Taxonomic identifier205914 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity. HAMAP MF_01601

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity. HAMAP MF_01601

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity. HAMAP MF_01601

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity. HAMAP MF_01601

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_0000323479

Regions

Nucleotide binding10 – 112NADP By similarity
Nucleotide binding31 – 322NADP By similarity
Nucleotide binding75 – 795NADP By similarity
Region200 – 2034Substrate binding By similarity

Sites

Active site1391Proton acceptor By similarity
Active site1771Proton acceptor By similarity
Binding site381NADP By similarity
Binding site531NADP By similarity
Binding site921NADP By similarity
Binding site1431NADP By similarity
Binding site1681Substrate By similarity
Binding site1691NADP; via amide nitrogen By similarity
Binding site1771NADP By similarity
Binding site1791Substrate; via carbonyl oxygen By similarity
Binding site1861Substrate By similarity
Binding site2081Substrate By similarity
Binding site2711Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0I569 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 790866DF9509FF7E

FASTA30934,866
        10         20         30         40         50         60 
MIIVTGGAGL IGSNIIAALN DMGRRDILVV DNLTDGTKFV NLVDLDIADY CDKEDFIASI 

        70         80         90        100        110        120 
IAGDDFGDID AIFHQGACSA TTEWNGKYLM QNNYEYSKEL LHYCLLREIP FFYASSAATY 

       130        140        150        160        170        180 
GDKTDFIEER QFEGPLNVYG YSKFLFDEYV RQILPQATSP VCGFKYFNVY GPREQHKGSM 

       190        200        210        220        230        240 
ASVAFHLNNQ MLKGENPKLF AGSEHFLRDF VYVGDVAKVN LWAWQHGISG IYNCGTGRAE 

       250        260        270        280        290        300 
SFEQVARAVL NYHGKGEIET IPFPEHLKSR YQEYTQANLT KLRAAGYQAE FKSVAEGVAE 


YMQWLNRKS

« Hide

References

[1]"Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd."
Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O., Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N., Xie G., Inzana T.J.
J. Bacteriol. 189:1890-1898(2007) [PubMed: 17172329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129Pt.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000436 Genomic DNA. Translation: ABI25881.1.
RefSeqYP_719818.1. NC_008309.1.

3D structure databases

ProteinModelPortalQ0I569.
SMRQ0I569. Positions 1-306.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0I569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4241140.
GenomeReviewsGene locus HS_1613 in contig CP000436_GR.
KEGGhso:HS_1613.
PATRIC20283381. VBIHaeSom53361_1690.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0451.
HOGENOMHBG755066.
OMARRDFIYV.
PhylomeDBQ0I569.
ProtClustDBPRK11150.

Enzyme and pathway databases

BioCycHSOM205914:HS_1613-MONOMER.

Family and domain databases

HAMAPMF_01601. Heptose_epimerase.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK03274.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. Heptose_epim. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHLDD_HAES1
AccessionPrimary (citable) accession number: Q0I569
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 3, 2006
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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